Effect of Basketball Sports on Serum Superoxide Dismutase and Its Relationship with the Nanoparticle Drug Delivery System

Human survival is impossible without oxygen, and as the body load continues to increase, the need for oxygen intake becomes greater. However, oxygen is also a double-edged sword for the human body. A large number of studies have proved that excessive intake of oxygen might lead to oxygen poisoning. Even under normal oxygen uptake, there is still a certain proportion of SOD conversion in oxygen. Superoxide dismutase (SOD) is one of the main causes of oxygen poisoning and chronic diseases. It is of great significance to study the changes of SOD in a large amount of oxygen environment. However, there are a few research studies in this field at home and abroad. Therefore, this paper puts forward the influence of basketball sports on serum superoxide dismutase (SOD) and its relationship with the nanoparticle drug delivery system. The research of this paper is mainly divided into three parts. The first part is the research of theoretical basis and core concepts. Through this part of the study, this paper shows that exercise can make the human body strong, while controlling the transformation of SOD, and only in this way can we achieve the true meaning of sports health. The second part is the establishment method of the test model of the influence of basketball on SOD and the nanoparticle drug delivery system. In this part, the principle and operation steps of the design method are given in detail. In order to ensure the effect of the experiment, the test standard was established, and the whole process data were recorded for the retrospective study. The third part is the comparative experiment, which includes the influence of different exercise intensities on SOD activity and the preservation stability of nanoparticles. Through the analysis of experimental data, it was found that basketball increased the risk of SOD transformation, but at the same time, using nanoparticles intervention can effectively reduce the harm of SOD to the human body.

Mechanistic basis of oxygen sensitivity in titanium

One of the most potent examples of interstitial solute strengthening in metal alloys is the extreme sensitivity of titanium to small amounts of oxygen. Unfortunately, these small amounts of oxygen also lead to a markedly decreased ductility, which in turn drives the increased cost to purify titanium to avoid this oxygen poisoning effect. Here, we report a systematic study on the oxygen sensitivity of titanium that provides a clear mechanistic view of how oxygen impurities affect the mechanical properties of titanium. The increased slip planarity of Ti-O alloys is caused by an interstitial shuffling mechanism, which is sensitive to temperature, strain rate, and oxygen content and leads to the subsequent alteration of deformation twinning behavior. The insights from our experimental and computational work provide a rationale for the design of titanium alloys with increased tolerance to variations in interstitial content, with notable implications for more widespread use of titanium alloys.

Prevalence of hyperoxemia in hospitals of southern Tamaulipas, Mexico during the period Aug-Oct 2019

Background Assisted ventilation represents high benefits for patients that cańt breathe normally or had suffered lung damage. The problem begins when there is an excessive assisted ventilation, that could lead to partial pression of the oxygen that cause hyperoxia and the result is oxygen poisoning [Hyperoxemia]. Reports have shown that cells, connective tissue, and organs can be affected by the hyperoxia. Our research consists in identifying hyperoxemia prevalence in Intensive Care Unit [ICU] at hospitals, so they can develop a better oxygen treatment. Methods The method we use in this investigation were: Nonexperimental, quantitative, retrospective, and transversal research, with the variable data PAO2, PCO2, SO2, age and gender. The subjects were distributed in normoxia and hyperoxemia. The population sample was of 19 patients from the Hospital A, B, and C in the south of Tamaulipas, Mexico, during the August-September 2019 period. The analytic technique used was the statistical average, which was of 137.9% in ICU. Results From 19 patients [100%], 15 patients with hyperoxemia [79%] and 4 patients with normoxemia [21.05%]. There was a difference between hyperoxemia: 10 male patients [52.63%] and 5 female patients [26.31%]. In the ICU, oxygen average saturation was 96.7%, and partial pressure of oxygen was 137.9% Conclusions We recommend performing a blood gas test in each patient with assisted ventilation, this with the purpose of regulate the administration of the oxygen inspiratory rate [FiO2]. Develop a clinic practice manual to regulate the administration of the oxygen inspiratory rate [FiO2] with assisted ventilation patients, with specifications and parameters to use it according each patient's characteristics and noted the consequences of a bad management on this. From 100% of patients [19], 79% [15] had hyperoxemia, which denotes that it is missing health surveillance to look after patient's health in the future. Key messages There are no beneficial effects of hyperoxemia in critical patients clearly demonstrated in clinical trials. The use of elevated FiO2 can produce a direct toxic effect on lung cells, with phenomena of cell destruction and alteration of defense mechanisms.

Oxidative Stress and Lung Ischemia-Reperfusion Injury

Ischemia-reperfusion (IR) injury is directly related to the formation of reactive oxygen species (ROS), endothelial cell injury, increased vascular permeability, and the activation of neutrophils and platelets, cytokines, and the complement system. Several studies have confirmed the destructiveness of the toxic oxygen metabolites produced and their role in the pathophysiology of different processes, such as oxygen poisoning, inflammation, and ischemic injury. Due to the different degrees of tissue damage resulting from the process of ischemia and subsequent reperfusion, several studies in animal models have focused on the prevention of IR injury and methods of lung protection. Lung IR injury has clinical relevance in the setting of lung transplantation and cardiopulmonary bypass, for which the consequences of IR injury may be devastating in critically ill patients.

A Study on Oxygen Leak-Diffusion Process and Environmental Influence of High-Pressure Liquid of Spherical Tank

Numerical prediction can analyze the cause and process of the accident comprehensively with the application of mathematical models. The computed results are more reliable and intuitive compared with the qualitative analysis results. Therefore, based on the Computational Fluid Dynamics (CFD) and the related theory of safety system science, leak and diffusion processes of high pressure liquid oxygen in spherical tank area, and the subsequent potential oxygen poisoning was analyzed by accident consequence assessment method. The given poisoning area and damage situation provide a reference for the safety analysis of oxygen storage and transportation.