A whole-body vibration program in type 2 diabetic patients

Adequate muscle perfusion is required for the maintenance of skeletal muscle mass. Impairments in microvascular structure and/or function with aging and type 2 diabetes have been associated with the progressive loss of skeletal muscle mass. Our objective was to compare muscle fiber type specific capillary density and endothelial function between healthy young men, healthy older men, and age-matched type 2 diabetes patients. Fifteen healthy young men (24 ± 1 yr), 15 healthy older men (70 ± 2 yr), and 15 age-matched type 2 diabetes patients (70 ± 1 yr) were selected to participate in the present study. Whole body insulin sensitivity, muscle fiber type specific capillary density, sublingual microvascular density, and dimension of the erythrocyte-perfused boundary region were assessed to evaluate the impact of aging and/or type 2 diabetes on microvascular structure and function. Whole body insulin sensitivity was significantly lower at a more advanced age, with lowest values reported in the type 2 diabetic patients. In line, skeletal muscle capillary contacts were much lower in the older and older type 2 diabetic patients when compared with the young. Sidestream darkfield imaging showed a significantly greater thickness of the erythrocyte perfused boundary region in the type 2 diabetic patients compared with the young. Skeletal muscle capillary density is reduced with aging and type 2 diabetes and accompanied by impairments in endothelial glycocalyx function, which is indicative of compromised vascular function.

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Whole body cryotherapy effect on weight gain and metabolic parameters of metabolic and type 2 diabetic patients

Endocrine Abstracts ◽

10.1530/endoabs.63.p930 ◽

2019 ◽

Author(s):

Maxim Lushchyk ◽

Larisa Danilova ◽

Hanna Tuzava ◽

Natallia Dudzik ◽

Sviatlana Zhauneryk

Keyword(s):

Weight Gain ◽

Metabolic Parameters ◽

Whole Body ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Whole Body Cryotherapy ◽

Type 2 Diabetic

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Decreased whole body lipolysis as a mechanism of the lipid-lowering effect of pioglitazone in type 2 diabetic patients

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.90960.2008 ◽

2009 ◽

Vol 297 (1) ◽

pp. E225-E230 ◽

Cited By ~ 16

Author(s):

Amalia Gastaldelli ◽

Arturo Casolaro ◽

Demetrio Ciociaro ◽

Silvia Frascerra ◽

Monica Nannipieri ◽

...

Keyword(s):

Lipid Lowering ◽

Whole Body ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Mixed Meal ◽

Plasma Triglycerides ◽

Insulin Resistant ◽

Type 2 Diabetic ◽

Lipid Lowering Effect

Pioglitazone has been shown to reduce fasting triglyceride levels. The mechanisms of this effect have not been fully elucidated, but decreased lipolysis may contribute to blunt the hypertriglyceridemic response to a meal. To test this hypothesis, we studied 27 type 2 diabetes mellitus (T2DM) patients and 7 sex-, age-, and body mass index-matched nondiabetic controls. Patients were randomized to pioglitazone (45 mg/day) or placebo for 16 wk. Whole body lipolysis was measured [as the [2H5]glycerol rate of appearance (Ra)] in the fasting state and for 6 h following a mixed meal. Compared with controls, T2DM had higher postprandial profiles of plasma triglycerides, free fatty acid (FFA), and β-hydroxybutyrate, and a decreased suppression of glycerol Ra ( P < 0.04) despite higher insulin levels [268 (156) vs. 190 (123) pmol/l, median (interquartile range)]. Following pioglitazone, triglycerides and FFA were reduced ( P = 0.05 and P < 0.04, respectively), and glycerol Ra was more suppressed [−40 (137) vs. +7 (202) μmol/min of placebo, P < 0.05] despite a greater fall in insulin [−85 (176) vs. −20 (58) pmol/l, P = 0.05]. We conclude that, in well-controlled T2DM patients, whole body lipolysis is insulin resistant, and pioglitazone improves the insulin sensitivity of lipolysis.

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