The effect of doxycycline on live birth rates in women with chronic endometritis suffering from recurrent miscarriage

Although many potential causes have been established for recurrent implantation failure (RIF) and recurrent miscarriage (RM), about 50% of these remain idiopathic. Scientific research is focused on immunological risk factors. In the present study, we aim to evaluate live birth rates after immunization with paternal lymphocytes (lymphocyte immunotherapy (LIT)). This retrospective study consisted of 148 couples with a history of RM and/or RIF. The women underwent immunization with lymphocytes of their respective partners from November 2017 to August 2019. Fifty-five patients (43%) had live births. Stratified by indication (RM, RIF, combined), live birth rates in the RM and the combined group were significantly higher than that in the RIF group (53%, 59% and 33%, respectively, p = 0.02). The difference was especially noticeable during the first 90 days after immunization (conception rate leading to live births: 31%, 23% and 8% for RM, the combined group and RIF, respectively; p = 0.005), while there was no difference between groups during the later follow-up. LIT was associated with high live birth rates, especially in women with recurrent miscarriage. In view of the limited data from randomized studies, LIT cannot be recommended as routine therapy. However, it may be considered in individual cases.

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Aspirin alone or combined with nadroparin did not increase live birth rates in women with unexplained recurrent miscarriage

Annals of Internal Medicine ◽

10.7326/0003-4819-153-8-201010190-02007 ◽

2010 ◽

Vol 153 (8) ◽

pp. JC4 ◽

Cited By ~ 2

Author(s):

Christopher J. Robinson

Keyword(s):

Live Birth ◽

Recurrent Miscarriage ◽

Birth Rates ◽

Live Birth Rates ◽

Unexplained Recurrent Miscarriage

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Is subclinical hypothyroidism associated with lower live birth rates in women who have experienced unexplained recurrent miscarriage?

Reproductive BioMedicine Online ◽

10.1016/j.rbmo.2016.09.002 ◽

2016 ◽

Vol 33 (6) ◽

pp. 745-751 ◽

Cited By ~ 8

Author(s):

Myrthe M. van Dijk ◽

Rosa Vissenberg ◽

Peter H. Bisschop ◽

Feroza Dawood ◽

Madelon van Wely ◽

...

Keyword(s):

Live Birth ◽

Subclinical Hypothyroidism ◽

Recurrent Miscarriage ◽

Birth Rates ◽

Live Birth Rates ◽

Unexplained Recurrent Miscarriage

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Does surgery improve live birth rates in patients with recurrent miscarriage caused by uterine anomalies?

Journal of Obstetrics and Gynaecology ◽

10.3109/01443615.2014.936839 ◽

2014 ◽

Vol 35 (2) ◽

pp. 155-158 ◽

Cited By ~ 19

Author(s):

M. Sugiura-Ogasawara ◽

B. L. Lin ◽

K. Aoki ◽

T. Maruyama ◽

M. Nakatsuka ◽

...

Keyword(s):

Live Birth ◽

Recurrent Miscarriage ◽

Birth Rates ◽

Live Birth Rates ◽

Uterine Anomalies

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Preimplantation Genetic Testing for Aneuploidy: Current Perspectives

Seminars in Reproductive Medicine ◽

10.1055/s-0041-1731828 ◽

2021 ◽

Author(s):

Ariadne L'Heveder ◽

Benjamin P. Jones ◽

Roy Naja ◽

Paul Serhal ◽

Jara Ben Nagi

Keyword(s):

Genetic Testing ◽

Live Birth ◽

Culture Media ◽

Recurrent Miscarriage ◽

Birth Rates ◽

Preimplantation Genetic Testing ◽

Live Birth Rates ◽

Future Direction ◽

Cost Implications ◽

The Cost

AbstractDespite improvements in assisted reproduction techniques (ARTs), live birth rates remain suboptimal, particularly in women with advanced maternal age (AMA). The leading cause of poor reproductive outcomes demonstrated in women with AMA, as well as women with recurrent miscarriage and repetitive implantation failure, is thought to be due to high rates of embryonic aneuploidy. Preimplantation genetic testing for aneuploidies (PGT-A) aims to select an euploid embryo for transfer and therefore improve ART outcomes. Early PGT-A studies using fluorescent in situ hybridization on mainly cleavage-stage biopsies failed to show improved delivery rates and, in certain cases, were even found to be harmful. However, the development of comprehensive chromosome screening, as well as improvements in culture media and vitrification techniques, has resulted in an emerging body of evidence in favor of PGT-A, demonstrating higher implantation, pregnancy, and live birth rates. While there are concerns regarding the potential harm of invasive biopsy and the cost implications of PGT-A, the introduction of noninvasive techniques and the development of new high-throughput methods which lower costs are tackling these issues. This review aims to assess the evidence for PGT-A, address possible concerns regarding PGT-A, and also explore the future direction of this technology.

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Histological diagnostic criterion for chronic endometritis based on the clinical outcome

BMC Women s Health ◽

10.1186/s12905-021-01239-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Kimiko Hirata ◽

Fuminori Kimura ◽

Akiko Nakamura ◽

Jun Kitazawa ◽

Aina Morimune ◽

...

Keyword(s):

Regression Analysis ◽

Live Birth ◽

High Power ◽

Birth Rate ◽

Plasma Cells ◽

Live Birth Rate ◽

Birth Rates ◽

Chronic Endometritis ◽

Live Birth Rates ◽

Diagnostic Criterion

Abstract Background The diagnostic criteria of chronic endometritis remain controversial in the treatment for infertile patients. Methods A prospective observational study was conducted in a single university from June 2014 to September 2017. Patients who underwent single frozen-thawed blastocyst transfer with a hormone replacement cycle after histological examination for the presence of chronic endometritis were enrolled. Four criteria were used to define chronic endometritis according to the number of plasma cells in the same group of patients: 1 or more (≥ 1) plasma cells, 2 or more (≥ 2), 3 or more (≥ 3), or 5 or more (≥ 5) in 10 high-power fields. Pregnancy rates, live birth rates, and miscarriage rates of the non-chronic endometritis and the chronic endometritis groups defined with each criterion were calculated. A logistic regression analysis was performed for live births using eight explanatory variables (seven infertility factors and chronic endometritis). A receiver operating characteristic curve was drawn and the optimal cut-off value was calculated. Results A total of 69 patients were registered and 53 patients were finally analyzed after exclusion. When the diagnostic criterion was designated as the presence of ≥ 1 plasma cell in the endometrial stroma per 10 high-power fields, the pregnancy rate, live birth rate, and miscarriage rate were 63.0% vs. 30.8%, 51.9% vs. 7.7%, and 17.7% vs. 75% in the non-chronic and chronic endometritis groups, respectively. This criterion resulted in the highest pregnancy and live birth rates among the non-chronic endometritis and the smallest P values for the pregnancy rates, live birth rates, and miscarriage rates between the non-chronic and chronic endometritis groups. In the logistic regression analysis, chronic endometritis was an explanatory variable negatively affecting the objective variable of live birth only when chronic endometritis was diagnosed with ≥ 1 or ≥ 2 plasma cells per 10 high-power fields. The optimal cut-off value was obtained when one or more plasma cells were found in 10 high-power fields (sensitivity 87.5%, specificity 64.9%). Conclusions Chronic endometritis should be diagnosed as the presence of ≥ 1 plasma cells in 10 high-power fields. According to this diagnostic criterion, chronic endometritis adversely affected the pregnancy rate and the live birth rate.

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