High-dose intravenous vitamin C reduces urinary tract infection post-kidney transplantation

Abstract Background Urinary tract infection (UTI) accounts for about half of all post- kidney transplant infections. There is conflicting data regarding vitamin C and UTI prevention. So far, its efficacy has not been studied in renal transplant patients. Methods Kidney transplant candidates were randomized between vitamin C and placebo arms. In the treatment group, patients received vitamin C infusion at a single dose of 70 mg/kg. In another study arm, only the diluent solution was administered. Data regarding bacteriuria during the first hospitalization after transplantation were recorded. Results A total of 19 patients were randomized to the placebo (n = 10) and vitamin C (n = 9) group. The rate of bacteriuria during the first hospitalization after transplantation was significantly lower in the vitamin C group than in the placebo group, 11.1% versus 60%, respectively. (P = 0.02). Conclusion Vitamin C as a safe treatment is a potential prophylactic agent in post kidney transplantation UTI.

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IMPACT OF EXTENDED-SPECTRUM BETA-LACTAMASE-PRODUCING ENTEROBACTERIACEAE URINARY TRACT INFECTION IN KIDNEY TRANSPLANT PATIENTS

Transplantation Journal ◽

10.1097/01.tp.0000332477.43280.51 ◽

2008 ◽

Vol 86 (Supplement) ◽

pp. 130

Author(s):

M-F Lam ◽

K-C Tse ◽

T Yip ◽

T-M Chan ◽

K-N Lai

Keyword(s):

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Kidney Transplant ◽

Beta Lactamase ◽

Extended Spectrum Beta Lactamase ◽

Transplant Patients ◽

Extended Spectrum ◽

Kidney Transplant Patients

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Urinary Tract Infection Caused by Extended-Spectrum Beta-Lactamase–Producing Bacteria in Kidney Transplant Patients

Transplantation Proceedings ◽

10.1016/j.transproceed.2010.02.002 ◽

2010 ◽

Vol 42 (2) ◽

pp. 486-487 ◽

Cited By ~ 40

Author(s):

H.S. Pinheiro ◽

A.M. Mituiassu ◽

M. Carminatti ◽

A.M. Braga ◽

M.G. Bastos

Keyword(s):

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Kidney Transplant ◽

Beta Lactamase ◽

Extended Spectrum Beta Lactamase ◽

Transplant Patients ◽

Extended Spectrum ◽

Kidney Transplant Patients

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A Current Review of the Etiology, Clinical Features, and Diagnosis of Urinary Tract Infection in Renal Transplant Patients

Diagnostics ◽

10.3390/diagnostics11081456 ◽

2021 ◽

Vol 11 (8) ◽

pp. 1456

Author(s):

María Luisa Suárez Fernández ◽

Natalia Ridao Cano ◽

Lucia Álvarez Santamarta ◽

María Gago Fraile ◽

Olivia Blake ◽

...

Keyword(s):

Urinary Tract Infection ◽

Kidney Transplantation ◽

Urinary Tract ◽

Tract Infection ◽

Asymptomatic Bacteriuria ◽

Multidrug Resistant ◽

Bk Virus ◽

Transplant Patients ◽

Current Guidelines ◽

Common Infection

Urinary tract infection (UTI) represents the most common infection after kidney transplantation and remains a major cause of morbidity and mortality in kidney transplant (KT) recipients, with a potential impact on graft survival. UTIs after KT are usually caused by Gram-negative microorganisms. Other pathogens which are uncommon in the general population should be considered in KT patients, especially BK virus since an early diagnosis is necessary to improve the prognosis. UTIs following kidney transplantation are classified into acute simple cystitis, acute pyelonephritis/complicated UTI, and recurrent UTI, due to their different clinical presentation, prognosis, and management. Asymptomatic bacteriuria (ASB) represents a frequent finding after kidney transplantation, but ASB is considered to be a separate entity apart from UTI since it is not necessarily a disease state. In fact, current guidelines do not recommend routine screening and treatment of ASB in KT patients, since a beneficial effect has not been shown. Harmful effects such as the development of multidrug-resistant (MDR) bacteria and a higher incidence of Clostridium difficile diarrhea have been associated with the antibiotic treatment of ASB.

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