scholarly journals Staphylococcal enterotoxin B administration in pregnant rats alters the splenic lymphocyte response in adult offspring rats

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Ping Zhou ◽  
Xin-sheng Zhang ◽  
Zhi-ben Xu ◽  
Shu-xian Gao ◽  
Qing-wei Zheng ◽  
...  
Keyword(s):  
Staphylococcal Enterotoxin ◽  
Splenic Lymphocyte ◽  
Adult Offspring ◽  
Staphylococcal Enterotoxin B ◽  
Lymphocyte Response ◽  
Pregnant Rats ◽  
Enterotoxin B

scholarly journals Prenatal exposure of staphylococcal enterotoxin B attenuates the development and function of blood regulatory T cells to repeated staphylococcal enterotoxin B exposure in adult offspring rats

2020 ◽  
Vol 69 (4) ◽  
pp. 591-599
Author(s):  
Shu-xian Gao ◽  
Jing Sun ◽  
Hui-hui Li ◽  
Jie Chen ◽  
Mohsin Raza Kashif ◽  
...  
Keyword(s):  
T Cells ◽  
Peripheral Blood ◽  
Absolute Number ◽  
Staphylococcal Enterotoxin ◽  
Adult Offspring ◽  
Staphylococcal Enterotoxin B ◽  
Pregnant Rats ◽  
Exposure During Pregnancy ◽  
Enterotoxin B ◽  
And Function

Introduction. Staphylococcal enterotoxin B (SEB) is an extensively studied super-antigen. A previous study by us suggested that SEB exposure during pregnancy could alter the percentage of CD4+ and CD8+ T cells in the peripheral blood of neonatal offspring rats. Aim. It is unknown whether SEB exposure during pregnancy can influence the development of regulatory T cells (Tregs) in the peripheral blood of neonatal offspring rats. Methodology. Pregnant rats at gestational day 16 were intravenously injected with 15 µg SEB. Peripheral blood was acquired from neonatal offspring rats on days 1, 3 and 5 after delivery and from adult offspring rats for determination of Treg number by cytometry, cytokines by ELISA, and FoxP3 expression by real-time PCR and western blot. Results. SEB given to pregnant rats significantly increased the absolute number of Tregs and the expression levels of FoxP3, IL-10 and TGF-β (P<0.05, P<0.01) in the peripheral blood of not only neonatal but also adult offspring rats. Furthermore, repeated SEB exposure in adult offspring rats significantly decreased the absolute number of Tregs (P<0.01), and the expression levels of FoxP3, IL-10 and TGF-β (P<0.05, P<0.01) in their peripheral blood. Conclusion. Prenatal SEB exposure attenuates the development and function of Tregs to repeated SEB exposure in the peripheral blood of adult offspring rats.

Exposure of pregnant rats to staphylococcal enterotoxin B attenuates the response of increased Tregs to re-exposure to SEB in the thymus of adult offspring

2020 ◽  
Vol 145 ◽  
pp. 104225
Author(s):  
Ping Zhou ◽  
Jie Chen ◽  
Hui-hui Li ◽  
Jing Sun ◽  
Shu-xian Gao ◽  
...  
Keyword(s):  
Staphylococcal Enterotoxin ◽  
Adult Offspring ◽  
Staphylococcal Enterotoxin B ◽  
Pregnant Rats ◽  
Enterotoxin B

Exposure of pregnant rats to staphylococcal enterotoxin B increases offspring splenic Treg number and function via decreasing FoxP3 methylation

Immunobiology ◽  
2021 ◽  
Vol 226 (2) ◽  
pp. 152060
Author(s):  
Shu-xian Gao ◽  
Chao Sun ◽  
Yu-ting Zhu ◽  
Jia-bao Zhao ◽  
Jing Sun ◽  
...  
Keyword(s):  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin B ◽  
Pregnant Rats ◽  
Treg Number ◽  
Enterotoxin B ◽  
And Function

scholarly journals Staphylococcal enterotoxin B administration during pregnancy imprints the increased CD4:CD8 T-cell ratio in the peripheral blood from neonatal to adult offspring rats

2015 ◽  
Vol 64 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Tao Zhang ◽  
Feng-ling Yu ◽  
Wen-xuan Yang ◽  
Miao-miao Ruan ◽  
Zhi-yuan Yue ◽  
...  
Keyword(s):  
T Cell ◽  
Peripheral Blood ◽  
Cd8 T Cell ◽  
Staphylococcal Enterotoxin ◽  
Adult Offspring ◽  
Staphylococcal Enterotoxin B ◽  
Cell Ratio ◽  
Enterotoxin B

Lymphocyte Response to Staphylococcal Enterotoxin B in Patients with Annular Erythema Associated with Sjögren Syndrome

1991 ◽  
Vol 18 (2) ◽  
pp. 63-68 ◽  
Author(s):  
Ichiro Katayama ◽  
Toshiya Asai ◽  
Shigeo Nishiyama ◽  
Kiyoshi Nishioka
Keyword(s):  
Sjögren Syndrome ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin B ◽  
Sjogren Syndrome ◽  
Lymphocyte Response ◽  
Annular Erythema ◽  
Enterotoxin B

scholarly journals Effect of Single Peptide Bond Scission by Trypsin on the Structure and Activity of Staphylococcal Enterotoxin B

1973 ◽  
Vol 248 (21) ◽  
pp. 7289-7294
Author(s):  
Leonard Spero ◽  
John R. Warren ◽  
Joseph F. Metzger
Keyword(s):  
Peptide Bond ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin B ◽  
Bond Scission ◽  
Enterotoxin B ◽  
Structure And Activity ◽  
Single Peptide

Induction of clonal anergy by oral administration of staphylococcal enterotoxin B

1994 ◽  
Vol 24 (9) ◽  
pp. 2081-2086 ◽  
Author(s):  
Kiyoshi Migita ◽  
Atsuo Ochi
Keyword(s):  
Oral Administration ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin B ◽  
Enterotoxin B ◽  
Clonal Anergy

scholarly journals Rapid and simultaneous detection of ricin, staphylococcal enterotoxin B and saxitoxin by chemiluminescence-based microarray immunoassay

The Analyst ◽  
2014 ◽  
Vol 139 (22) ◽  
pp. 5885-5892 ◽  
Author(s):  
A. Szkola ◽  
E. M. Linares ◽  
S. Worbs ◽  
B. G. Dorner ◽  
R. Dietrich ◽  
...  
Keyword(s):  
Simultaneous Detection ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin B ◽  
Microarray Immunoassay ◽  
Enterotoxin B ◽  
Idiotypic Antibody

Simultaneous detection of proteotoxins, ricin and SEB, and small toxin, STX, on a chemiluminescence-based microarray using anti-idiotypic antibody for STX.

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