scholarly journals Extracting knowledge networks from plant scientific literature: potato tuber flesh color as an exemplary trait

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Gurnoor Singh ◽  
Evangelia A. Papoutsoglou ◽  
Frederique Keijts-Lalleman ◽  
Bilyana Vencheva ◽  
Mark Rice ◽  
...  
Keyword(s):  
Language Processing ◽  
Scientific Literature ◽  
Relevant Information ◽  
Hypothesis Generation ◽  
Knowledge Networks ◽  
Free Text ◽  
Flesh Color ◽  
Biological Phenomena ◽  
Structured Information ◽  
Biological Entities

Abstract Background Scientific literature carries a wealth of information crucial for research, but only a fraction of it is present as structured information in databases and therefore can be analyzed using traditional data analysis tools. Natural language processing (NLP) is often and successfully employed to support humans by distilling relevant information from large corpora of free text and structuring it in a way that lends itself to further computational analyses. For this pilot, we developed a pipeline that uses NLP on biological literature to produce knowledge networks. We focused on the flesh color of potato, a well-studied trait with known associations, and we investigated whether these knowledge networks can assist us in formulating new hypotheses on the underlying biological processes. Results We trained an NLP model based on a manually annotated corpus of 34 full-text potato articles, to recognize relevant biological entities and relationships between them in text (genes, proteins, metabolites and traits). This model detected the number of biological entities with a precision of 97.65% and a recall of 88.91% on the training set. We conducted a time series analysis on 4023 PubMed abstract of plant genetics-based articles which focus on 4 major Solanaceous crops (tomato, potato, eggplant and capsicum), to determine that the networks contained both previously known and contemporaneously unknown leads to subsequently discovered biological phenomena relating to flesh color. A novel time-based analysis of these networks indicates a connection between our trait and a candidate gene (zeaxanthin epoxidase) already two years prior to explicit statements of that connection in the literature. Conclusions Our time-based analysis indicates that network-assisted hypothesis generation shows promise for knowledge discovery, data integration and hypothesis generation in scientific research.

scholarly journals Extracting Knowledge Networks from Plant Scientific Literature: Potato Tuber Flesh Color as an Exemplary Trait

2020 ◽  
Author(s):  
Gurnoor Singh ◽  
Evangelia Papoutsoglou ◽  
Frederique Keijts-Lalleman ◽  
Bilyana Vencheva ◽  
Mark Rice ◽  
...  
Keyword(s):  
Language Processing ◽  
Scientific Literature ◽  
Relevant Information ◽  
Hypothesis Generation ◽  
Knowledge Networks ◽  
Free Text ◽  
Color Analysis ◽  
Flesh Color ◽  
Biological Phenomena ◽  
Biological Entities

Abstract Background: Scientific literature carries a wealth of information crucial for research, but only a fraction of it is present as structured information in databases and therefore can be analyzed using traditional data analysis tools. Natural language processing (NLP) is often and successfully employed to support humans by distilling relevant information from large corpora of free text and structuring it in a way that lends itself to further computational analyses. For this pilot, we developed a pipeline that uses NLP on biological literature to produce knowledge networks. We focused on the flesh color of potato, a well-studied trait with known associations, and we investigated whether these knowledge networks can assist us in formulating new hypotheses on the underlying biological processes. Results: We trained an NLP model based on a manually annotated corpus of 34 full-text potato articles, to recognize relevant biological entities and relationships between them in text (genes, proteins, metabolites and traits). This model detected the number of biological entities with a precision of 97.65% and a recall of 88.91% on the training set. We conducted a time series analysis on 4023 PubMed abstract of plant genetics-based articles which focus on 4 major Solanaceous crops (tomato, potato, eggplant and capsicum), to determine that the networks contained both previously known and contemporaneously unknown leads to subsequently discovered biological phenomena relating to flesh color. Analysis of these networks indicates a connection between our trait and a candidate gene (zeaxanthin epoxidase) already two years prior to explicit statements of that connection in the literature. Conclusions: Our time-based analysis indicates that network-assisted hypothesis generation shows promise for knowledge discovery, data integration and hypothesis generation in scientific research.

scholarly journals Sentiment Analysis Techniques Applied to Raw-Text Data from a Csq-8 Questionnaire about Mindfulness in Times of COVID-19 to Improve Strategy Generation

2021 ◽  
Vol 18 (12) ◽  
pp. 6408
Author(s):  
Mario Jojoa Acosta ◽  
Gema Castillo-Sánchez ◽  
Begonya Garcia-Zapirain ◽  
Isabel de la Torre Díez ◽  
Manuel Franco-Martín
Keyword(s):  
Health Care ◽  
Natural Language Processing ◽  
Natural Language ◽  
Sentiment Analysis ◽  
Transfer Learning ◽  
Language Processing ◽  
Health Care Professionals ◽  
Ground Truth ◽  
Relevant Information ◽  
Free Text

The use of artificial intelligence in health care has grown quickly. In this sense, we present our work related to the application of Natural Language Processing techniques, as a tool to analyze the sentiment perception of users who answered two questions from the CSQ-8 questionnaires with raw Spanish free-text. Their responses are related to mindfulness, which is a novel technique used to control stress and anxiety caused by different factors in daily life. As such, we proposed an online course where this method was applied in order to improve the quality of life of health care professionals in COVID 19 pandemic times. We also carried out an evaluation of the satisfaction level of the participants involved, with a view to establishing strategies to improve future experiences. To automatically perform this task, we used Natural Language Processing (NLP) models such as swivel embedding, neural networks, and transfer learning, so as to classify the inputs into the following three categories: negative, neutral, and positive. Due to the limited amount of data available—86 registers for the first and 68 for the second—transfer learning techniques were required. The length of the text had no limit from the user’s standpoint, and our approach attained a maximum accuracy of 93.02% and 90.53%, respectively, based on ground truth labeled by three experts. Finally, we proposed a complementary analysis, using computer graphic text representation based on word frequency, to help researchers identify relevant information about the opinions with an objective approach to sentiment. The main conclusion drawn from this work is that the application of NLP techniques in small amounts of data using transfer learning is able to obtain enough accuracy in sentiment analysis and text classification stages.

Relational paraphrase acquisition from Wikipedia: The WRPA method and corpus

2013 ◽  
Vol 21 (3) ◽  
pp. 355-389 ◽  
Author(s):  
M. VILA ◽  
H. RODRÍGUEZ ◽  
M. A. MARTÍ
Keyword(s):  
Natural Language Processing ◽  
Natural Language ◽  
High Precision ◽  
Language Processing ◽  
The Body ◽  
Free Text ◽  
String Similarity ◽  
Distant Learning ◽  
Structured Information ◽  
Anchor Points

AbstractParaphrase corpora are an essential but scarce resource in Natural Language Processing. In this paper, we present the Wikipedia-based Relational Paraphrase Acquisition (WRPA) method, which extracts relational paraphrases from Wikipedia, and the derived WRPA paraphrase corpus. The WRPA corpus currently covers person-related and authorship relations in English and Spanish, respectively, suggesting that, given adequate Wikipedia coverage, our method is independent of the language and the relation addressed. WRPA extracts entity pairs from structured information in Wikipedia applying distant learning and, based on the distributional hypothesis, uses them as anchor points for candidate paraphrase extraction from the free text in the body of Wikipedia articles. Focussing on relational paraphrasing and taking advantage of Wikipedia-structured information allows for an automatic and consistent evaluation of the results. The WRPA corpus characteristics distinguish it from other types of corpora that rely on string similarity or transformation operations. WRPA relies on distributional similarity and is the result of the free use of language outside any reformulation framework. Validation results show a high precision for the corpus.

scholarly journals Structured reviews for data and knowledge-driven research

Database ◽  
2020 ◽  
Vol 2020 ◽  
Author(s):  
Núria Queralt-Rosinach ◽  
Gregory S Stupp ◽  
Tong Shu Li ◽  
Michael Mayers ◽  
Maureen E Hoatlin ◽  
...  
Keyword(s):  
Field Research ◽  
Hypothesis Generation ◽  
Knowledge Graph ◽  
Free Text ◽  
Seamless Integration ◽  
Domain Experts ◽  
Review Articles ◽  
Structured Information ◽  
Data Files ◽  
Computational Analyses

Abstract Hypothesis generation is a critical step in research and a cornerstone in the rare disease field. Research is most efficient when those hypotheses are based on the entirety of knowledge known to date. Systematic review articles are commonly used in biomedicine to summarize existing knowledge and contextualize experimental data. But the information contained within review articles is typically only expressed as free-text, which is difficult to use computationally. Researchers struggle to navigate, collect and remix prior knowledge as it is scattered in several silos without seamless integration and access. This lack of a structured information framework hinders research by both experimental and computational scientists. To better organize knowledge and data, we built a structured review article that is specifically focused on NGLY1 Deficiency, an ultra-rare genetic disease first reported in 2012. We represented this structured review as a knowledge graph and then stored this knowledge graph in a Neo4j database to simplify dissemination, querying and visualization of the network. Relative to free-text, this structured review better promotes the principles of findability, accessibility, interoperability and reusability (FAIR). In collaboration with domain experts in NGLY1 Deficiency, we demonstrate how this resource can improve the efficiency and comprehensiveness of hypothesis generation. We also developed a read–write interface that allows domain experts to contribute FAIR structured knowledge to this community resource. In contrast to traditional free-text review articles, this structured review exists as a living knowledge graph that is curated by humans and accessible to computational analyses. Finally, we have generalized this workflow into modular and repurposable components that can be applied to other domain areas. This NGLY1 Deficiency-focused network is publicly available at http://ngly1graph.org/. Availability and implementation Database URL: http://ngly1graph.org/. Network data files are at: https://github.com/SuLab/ngly1-graph and source code at: https://github.com/SuLab/bioknowledge-reviewer. Contact [email protected]

scholarly journals Structured Reviews for Data and Knowledge Driven Research

2019 ◽  
Author(s):  
Núria Queralt-Rosinach ◽  
Gregory S. Stupp ◽  
Tong Shu Li ◽  
Michael Mayers ◽  
Maureen E. Hoatlin ◽  
...  
Keyword(s):  
Field Research ◽  
Hypothesis Generation ◽  
Knowledge Graph ◽  
Free Text ◽  
Seamless Integration ◽  
Domain Experts ◽  
Link Type ◽  
Review Articles ◽  
Structured Information ◽  
Data Files

AbstractMotivationHypothesis generation is a critical step in research and a cornerstone in the rare disease field. Research is most efficient when those hypotheses are based on the entirety of knowledge known to date. Systematic review articles are commonly used in biomedicine to summarize existing knowledge and contextualize experimental data. But the information contained within review articles is typically only expressed as free-text, which is difficult to use computationally. Researchers struggle to navigate, collect and remix prior knowledge as it is scattered in several silos without seamless integration and access. This lack of a structured information framework hinders research by both experimental and computational scientists.ResultsTo better organize knowledge and data, we built a structured review article that is specifically focused on NGLY1 Deficiency, an ultra-rare genetic disease first reported in 2012. We represented this structured review as a knowledge graph, and then stored this knowledge graph in a Neo4j database to simplify dissemination, querying, and visualization of the network. Relative to free-text, this structured review better promotes the principles of findability, accessibility, interoperability, and reusability (FAIR). In collaboration with domain experts in NGLY1 Deficiency, we demonstrate how this resource can improve the efficiency and comprehensiveness of hypothesis generation. We also developed a read-write interface that allows domain experts to contribute FAIR structured knowledge to this community resource. In contrast to traditional free-text review articles, this structured review exists as a living knowledge graph that is curated by humans and accessible to computational analyses. Finally, we have generalized this workflow into modular and repurposable components that can be applied to other domain areas. This NGLY1 Deficiency-focused network is publicly available at http://ngly1graph.org/.Availability and implementationSource code and network data files are at: https://github.com/SuLab/ngly1-graph and https://github.com/SuLab/[email protected]

scholarly journals Cohort profile: St. Michael's Hospital Tuberculosis Database (SMH-TB), a retrospective cohort of electronic health record data and variables extracted using natural language processing

2020 ◽  
Author(s):  
David Landsman ◽  
Ahmed Abdelbasit ◽  
Christine Wang ◽  
Michael Guerzhoy ◽  
Ujash Joshi ◽  
...  
Keyword(s):  
Natural Language Processing ◽  
Natural Language ◽  
Language Processing ◽  
Clinical Epidemiology ◽  
Relevant Information ◽  
Structured Data ◽  
Free Text ◽  
Electronic Health Record Data ◽  
Latent Tb ◽  
Electronic Health

Background Tuberculosis (TB) is a major cause of death worldwide. TB research draws heavily on clinical cohorts which can be generated using electronic health records (EHR), but granular information extracted from unstructured EHR data is limited. The St. Michael's Hospital TB database (SMH-TB) was established to address gaps in EHR-derived TB clinical cohorts and provide researchers and clinicians with detailed, granular data related to TB management and treatment. Methods We collected and validated multiple layers of EHR data from the TB outpatient clinic at St. Michael's Hospital, Toronto, Ontario, Canada to generate the SMH-TB database. SMH-TB contains structured data directly from the EHR, and variables generated using natural language processing (NLP) by extracting relevant information from free-text within clinic, radiology, and other notes. NLP performance was assessed using recall, precision and F1 score averaged across variable labels. We present characteristics of the cohort population using binomial proportions and 95% confidence intervals (CI), with and without adjusting for NLP misclassification errors. Results SMH-TB currently contains retrospective patient data spanning 2011 to 2018, for a total of 3298 patients (N=3237 with at least 1 associated dictation). Performance of TB diagnosis and medication NLP rulesets surpasses 93% in recall, precision and F1 metrics, indicating good generalizability. We estimated 20% (95% CI: 18.4-21.2%) were diagnosed with active TB and 46% (95% CI: 43.8-47.2%) were diagnosed with latent TB. After adjusting for potential misclassification, the proportion of patients diagnosed with active and latent TB was 18% (95% CI: 16.8-19.7%) and 40% (95% CI: 37.8-41.6%) respectively Conclusion SMH-TB is a unique database that includes a breadth of structured data derived from structured and unstructured EHR data. The data are available for a variety of research applications, such as clinical epidemiology, quality improvement and mathematical modelling studies.

scholarly journals Cohort profile: St. Michael’s Hospital Tuberculosis Database (SMH-TB), a retrospective cohort of electronic health record data and variables extracted using natural language processing

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0247872
Author(s):  
David Landsman ◽  
Ahmed Abdelbasit ◽  
Christine Wang ◽  
Michael Guerzhoy ◽  
Ujash Joshi ◽  
...  
Keyword(s):  
Natural Language Processing ◽  
Natural Language ◽  
Language Processing ◽  
Clinical Epidemiology ◽  
Relevant Information ◽  
Structured Data ◽  
Free Text ◽  
Electronic Health Record Data ◽  
Latent Tb ◽  
Electronic Health

Background Tuberculosis (TB) is a major cause of death worldwide. TB research draws heavily on clinical cohorts which can be generated using electronic health records (EHR), but granular information extracted from unstructured EHR data is limited. The St. Michael’s Hospital TB database (SMH-TB) was established to address gaps in EHR-derived TB clinical cohorts and provide researchers and clinicians with detailed, granular data related to TB management and treatment. Methods We collected and validated multiple layers of EHR data from the TB outpatient clinic at St. Michael’s Hospital, Toronto, Ontario, Canada to generate the SMH-TB database. SMH-TB contains structured data directly from the EHR, and variables generated using natural language processing (NLP) by extracting relevant information from free-text within clinic, radiology, and other notes. NLP performance was assessed using recall, precision and F1 score averaged across variable labels. We present characteristics of the cohort population using binomial proportions and 95% confidence intervals (CI), with and without adjusting for NLP misclassification errors. Results SMH-TB currently contains retrospective patient data spanning 2011 to 2018, for a total of 3298 patients (N = 3237 with at least 1 associated dictation). Performance of TB diagnosis and medication NLP rulesets surpasses 93% in recall, precision and F1 metrics, indicating good generalizability. We estimated 20% (95% CI: 18.4–21.2%) were diagnosed with active TB and 46% (95% CI: 43.8–47.2%) were diagnosed with latent TB. After adjusting for potential misclassification, the proportion of patients diagnosed with active and latent TB was 18% (95% CI: 16.8–19.7%) and 40% (95% CI: 37.8–41.6%) respectively Conclusion SMH-TB is a unique database that includes a breadth of structured data derived from structured and unstructured EHR data by using NLP rulesets. The data are available for a variety of research applications, such as clinical epidemiology, quality improvement and mathematical modeling studies.

scholarly journals Sentiment Analysis Techniques Applied to Raw-Text Data from a CSQ-8 Questionnaire About Mindfulness in Times of Covid-19 to Improve Strategy Generation

2021 ◽  
Author(s):  
Mario Jojoa ◽  
Gema Castillo-Sánchez ◽  
Begonya Garcia-Zapirain ◽  
Isabel De la Torre Diez ◽  
Manuel Franco-Martín
Keyword(s):  
Sentiment Analysis ◽  
Transfer Learning ◽  
Language Processing ◽  
Health Care Professionals ◽  
Ground Truth ◽  
Relevant Information ◽  
Free Text ◽  
Text Data ◽  
Learning Techniques

The aim of this study was to build a tool to analyze, using artificial intelligence, the sentiment perception of users who answered two questions from the CSQ – 8 questionnaires with raw Spanish free-text. Their responses are related to mindfulness, which is a novel technique used to control stress and anxiety caused by different factors in daily life. As such, we proposed an online course where this method was applied in order to improve the quality of life of health care professionals in COVID 19 pandemic times. We also carried out an evaluation of the satis-faction level of the participants involved, with a view to establishing strategies to improve fu-ture experiences. To automatically perform this task, we used Natural Language Processing (NLP) models such as swivel embedding, neural networks and transfer learning, so as to classify the inputs into the following 3 categories: negative, neutral and positive. Due to the lim-ited amount of data available - 86 registers for the first and 68 for the second - transfer learning techniques were required. The length of the text had no limit from the user’s standpoint, and our approach attained a maximum accuracy of 93.02 % and 90.53 % respectively based on ground truth labeled by 3 experts. Finally, we proposed a complementary analysis, using com-puter graphic text representation based on word frequency, to help researchers identify relevant information about the opinions with an objective approach to sentiment. The main conclusion drawn from this work is that the application of NLP techniques in small amounts of data using transfer learning is able to obtain enough accuracy in sentiment analysis and text classification stages

scholarly journals Automated literature mining and hypothesis generation through a network of Medical Subject Headings

2018 ◽  
Author(s):  
Stephen Joseph Wilson ◽  
Angela Dawn Wilkins ◽  
Matthew V. Holt ◽  
Byung Kwon Choi ◽  
Daniel Konecki ◽  
...  
Keyword(s):  
Language Processing ◽  
Scientific Literature ◽  
Growth Factor Receptor ◽  
Direct Interaction ◽  
Hypothesis Generation ◽  
Supervised Machine Learning ◽  
Literature Mining ◽  
Cancer Genes ◽  
Medical Subject Headings ◽  
Mesh Terms

ABSTRACTThe scientific literature is vast, growing, and increasingly specialized, making it difficult to connect disparate observations across subfields. To address this problem, we sought to develop automated hypothesis generation by networking at scale the MeSH terms curated by the National Library of Medicine. The result is a Mesh Term Objective Reasoning (MeTeOR) approach that tallies associations among genes, drugs and diseases from PubMed and predicts new ones.Comparisons to reference databases and algorithms show MeTeOR tends to be more reliable. We also show that many predictions based on the literature prior to 2014 were published subsequently. In a practical application, we validated experimentally a surprising new association found by MeTeOR between novel Epidermal Growth Factor Receptor (EGFR) associations and CDK2. We conclude that MeTeOR generates useful hypotheses from the literature (http://meteor.lichtargelab.org/).AUTHOR SUMMARYThe large size and exponential expansion of the scientific literature forms a bottleneck to accessing and understanding published findings. Manual curation and Natural Language Processing (NLP) aim to address this bottleneck by summarizing and disseminating the knowledge within articles as key relationships (e.g. TP53 relates to Cancer). However, these methods compromise on either coverage or accuracy, respectively. To mitigate this compromise, we proposed using manually-assigned keywords (MeSH terms) to extract relationships from the publications and demonstrated a comparable coverage but higher accuracy than current NLP methods. Furthermore, we combined the extracted knowledge with semi-supervised machine learning to create hypotheses to guide future work and discovered a direct interaction between two important cancer genes.

scholarly journals Mining Cancer-related Information in Electronic Healthcare Records with Natural Language Processing

2018 ◽  
Vol 1 (1) ◽  
pp. 003-004
Author(s):  
Man Liu
Keyword(s):  
Natural Language Processing ◽  
Natural Language ◽  
Language Processing ◽  
Relevant Information ◽  
The United States ◽  
Cancer Information ◽  
Free Text ◽  
Health Records ◽  
Related Information ◽  
Structured Representation

Cancer is in the midst of leading causes of death. In 2018, around 1,735,350 new cases of cancer were estimated and 609,640 people will die from cancer in the United States. A wealth of cancer-relevant information is conserved in a variety of types of healthcare records, for example, the electronic health records (EHRs). However, part of the critical information is organized in the free narrative text which hampers machine to interpret the information underlying the text. The development of artificial intelligence provides a variety of solutions to this plight. For example, the technology of natural language processing (NLP) has emerged bridging the gap between free text and structured representation of cancer information. Recently, several researchers have published their work on unearthing cancer-related information in EHRs based on the NLP technology. Apart from the traditional NLP methods, the development of deep learning helps EHRs mining go further.

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