scholarly journals The validity of central venous to arterial carbon dioxide difference to predict adequate fluid management during living donor liver transplantation. A prospective observational study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Mohamed ELAyashy ◽  
Hisham Hosny ◽  
Amr Hussein ◽  
Ahmed AbdelAal Ahmed Mahmoud ◽  
Ahmed Mukhtar ◽  
...  
2021 ◽  
Vol 10 (12) ◽  
pp. 2729
Author(s):  
Li-Min Hu ◽  
Hsin-I Tsai ◽  
Chao-Wei Lee ◽  
Hui-Ming Chen ◽  
Wei-Chen Lee ◽  
...  

Early allograft dysfunction (EAD) is a postoperative complication that may cause graft failure and mortality after liver transplantation. The objective of this study was to examine whether the preoperative serum uric acid (SUA) level may predict EAD. We performed a prospective observational study, including 61 donor/recipient pairs who underwent living donor liver transplantation (LDLT). In the univariate and multivariate analysis, SUA ≤4.4 mg/dL was related to a five-fold (odds ratio (OR): 5.16, 95% confidence interval (CI): 1.41–18.83; OR: 5.39, 95% CI: 1.29–22.49, respectively) increased risk for EAD. A lower preoperative SUA was related to a higher incidence of and risk for EAD. Our study provides a new predictor for evaluating EAD and may exert a protective effect against EAD development.


2019 ◽  
Author(s):  
Mohamed Elayashy ◽  
Hisham Hosny ◽  
Amr Hussein ◽  
Ahmed Abdelaal Ahmed Mahmoud ◽  
Ahmed Mukhtar ◽  
...  

Abstract Background: to assess the validity of Central and Pulmonary CO2 gaps to predict and guide fluid management during liver transplantation. Methods: Intraoperative fluid management was guided by pulse pressure variations (PPV). PPV of ≥15% triggered fluid resuscitation with 250 ml albumin 5% boluses to restoret PPV to <15%. Simultaneous blood sampling from central venous and pulmonary artery catheters (PAC) were clolected to calculate central and pulmonary CO2 gap. Patients were considered Fluid Responsive (FRS) if fluid boluses restored PPV to <15% and Fluid non-Responsive (FnRS) if not. CO and lactate and their correlation to CO2 gaps were also recorded. Results: The discriminative ability of Central and Pulmonary CO2 gaps between the two statuses (FRS and FnRS) was poor. AUC of ROC were 0.698 and 0.570 respectively. The Central CO2 gap was significantly higher in FRS than FnRS (P=0.016), with no difference in Pulmonary CO2 gap between both statuses. conclusion: Central and the Pulmonary CO2 gaps cannot be used alone as valid tools to predict fluid responsiveness and guide fluid management during liver transplantation. CO2 gaps do not correlate well with the changes in PPV or CO Trial registration: Clinicaltrials.gov NCT03123172. Registered on 31-march-2017


2020 ◽  
Vol 52 (6) ◽  
pp. 1798-1801
Author(s):  
Chih-Hsien Wang ◽  
Cheng-En Tsai ◽  
Kwok-Wai Cheng ◽  
Chao-Long Chen ◽  
Chia-Jung Huang ◽  
...  

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