Ultrasound contrast agent Sonazoid for the diagnosis of hepatic epithelioid angiomyolipoma: a case report

Abstract Background An angiomyolipoma usually occurs in the kidneys and rarely in the liver. Hepatic epithelioid angiomyolipoma (HEAML), a rare variant of angiomyolipoma, possesses malignant potential and mimics the imaging features of hepatocellular carcinoma. Sonazoid® (perfluorobutane microbubbles), a new contrast agent that facilitates hepatic parenchyma-specific Kupffer phase imaging on contrast-enhanced ultrasonography (CEUS), is useful for the detection and characterization of focal liver lesions. Case presentation A 30-year-old man with HEAML underwent CEUS using Sonazoid®, in which new concepts for ultrasonography-based differentiation between HEAML and hepatocellular carcinoma were applied. Conclusions This case report provides clinicians and radiologists with a reference for distinguishing HEAML from hepatocellular carcinoma based on CEUS using Sonazoid®.

Download Full-text

Evaluation of hepatocellular carcinoma using SonoVue, a second generation ultrasound contrast agent: correlation with cellular differentiation

European Radiology ◽

10.1007/s00330-004-2298-0 ◽

2004 ◽

Vol 14 (6) ◽

pp. 1092-1099 ◽

Cited By ~ 156

Author(s):

Carlos Nicolau ◽

Violeta Catal� ◽

Ram�n Vilana ◽

Rosa Gilabert ◽

Luis Bianchi ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Contrast Agent ◽

Cellular Differentiation ◽

Second Generation ◽

Ultrasound Contrast Agent ◽

Ultrasound Contrast

Download Full-text

Use of contrast-enhanced ultrasonography with a perflubutane-based contrast agent performed one day after transarterial chemoembolization for the early assessment of residual viable hepatocellular carcinoma

European Journal of Radiology ◽

10.1016/j.ejrad.2013.04.045 ◽

2013 ◽

Vol 82 (9) ◽

pp. 1471-1480 ◽

Cited By ~ 18

Author(s):

Kenichi Takizawa ◽

Kazushi Numata ◽

Manabu Morimoto ◽

Masaaki Kondo ◽

Akito Nozaki ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Contrast Agent ◽

Transarterial Chemoembolization ◽

Early Assessment ◽

Contrast Enhanced ◽

Contrast Enhanced Ultrasonography

Download Full-text

Role of Contrast-Enhanced Ultrasonography in Hepatocellular Carcinoma by Using LI-RADS and Ancillary Features: A Single Tertiary Centre Experience

Diagnostics ◽

10.3390/diagnostics11122232 ◽

2021 ◽

Vol 11 (12) ◽

pp. 2232

Author(s):

Adriana Ciocalteu ◽

Sevastita Iordache ◽

Sergiu Marian Cazacu ◽

Cristiana Marinela Urhut ◽

Sarmis Marian Sandulescu ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Diagnostic Yield ◽

High Specificity ◽

Final Diagnosis ◽

Focal Liver Lesions ◽

Liver Imaging ◽

Tertiary Centre ◽

Contrast Enhanced ◽

Contrast Enhanced Ultrasonography ◽

Ancillary Features

Clinical utility of ancillary features (AFs) in contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System (LI-RADS®) is yet to be established. In this study, we assessed the diagnostic yield of CEUS LI-RADS and AFs in hepatocellular carcinoma (HCC). We retrospectively included patients with risk factors for HCC and newly diagnosed focal liver lesions (FLL). All lesions have been categorized according to the CEUS LI-RADS v2017 by an experienced sonographer blinded to clinical data and to the final diagnosis. From a total of 143 patients with 191 FLL, AFs favoring HCC were observed in 19.8% cases as hypoechoic rim and in 16.7% cases as nodule-in nodule architecture. From the total of 141 HCC cases, 83.6% were correctly classified: 57.4%- LR-5 and 26.2%- LR-4. In 9.21% cases, CEUS indicated LR-M; 2.12% cases- LR-3. The LR-5 category was 96.2% predictive (PPV) of HCC. LR-5 had 60.4% sensitivity and 93.6% specificity. PPV for primitive malignancy (LR-4 + LR-5) was 95.7%, with 88% sensitivity, 89.3% specificity and 88.4% accuracy for HCC. LR-4 category had 94.8% PPV and 26.2% sensitivity. CEUS LR4 + LR5 had 81,8% sensitivity for HCCs over 2 cm and 78.57% sensitivity for smaller HCCs. CEUS LR-5 remains an excellent diagnostic tool for HCC, despite the size of the lesion. The use of AFs might improve the overarching goal of LR-5 + LR-4 diagnosis of high specificity for HCC and exclusion of non-HCC malignancy.

Download Full-text

Hepatic Epithelioid Angiomyolipoma Treated with Laparoscopic Resection: Case Report and Review of the Literature

Case Reports in Hepatology ◽

10.1155/2019/2362618 ◽

2019 ◽

Vol 2019 ◽

pp. 1-4

Author(s):

Chloe H. Williams ◽

Kelli Hickle ◽

Katherine Bakke ◽

Sarah Jamshed ◽

Adel Bozorgzadeh

Keyword(s):

Hepatocellular Carcinoma ◽

Liver Tumor ◽

Laparoscopic Resection ◽

Imaging Features ◽

Review Of The Literature ◽

Hepatic Angiomyolipoma ◽

Epithelioid Angiomyolipoma ◽

Radiographic Appearance ◽

Primary Liver Tumor ◽

Noncirrhotic Patient

Hepatic angiomyolipoma is a rare primary liver tumor, with a radiographic appearance very similar to hepatocellular carcinoma. We present the case of a noncirrhotic patient with a liver tumor suspicious for HCC by imaging features. Liver biopsy demonstrated angiomyolipoma, and the patient successfully underwent a laparoscopic liver resection.

Download Full-text