scholarly journals Tuberculous meningitis is a major cause of mortality and morbidity in adults with central nervous system infections in Kota Kinabalu, Sabah, Malaysia: an observational study

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Heng Gee Lee ◽  
Timothy William ◽  
Jayaram Menon ◽  
Anna P. Ralph ◽  
Eng Eong Ooi ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Observational Study ◽  
Tuberculous Meningitis ◽  
Central Nervous System Infections ◽  
Mortality And Morbidity

Treatment of Central Nervous System Tuberculosis

2018 ◽  
Vol 13 (02) ◽  
pp. 141-152
Author(s):  
Amina Ahmed
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Tuberculous Meningitis ◽  
Diagnosis And Treatment ◽  
Duration Of Treatment ◽  
Standard Regimen ◽  
Mortality And Morbidity ◽  
Improved Outcomes ◽  
Prompt Diagnosis ◽  
Optimal Regimen

AbstractCentral nervous system tuberculosis (CNS-TB) manifests as tuberculous meningitis, intracranial tuberculoma, or spinal tuberculous arachnoiditis. Children are disproportionately affected, with high rates of mortality and morbidity reported even in the era of treatment. Most guidelines for the treatment of drug-susceptible CNS-TB recommend 9 to 12 months of a standard regimen of isoniazid, rifampin, pyrazinamide, and ethambutol, with the adjunctive use of corticosteroids early in therapy. Recent trials have demonstrated improved outcomes with intensified regimens using nonstandard regimens or higher dosages of standard drugs. Accumulating evidence also supports shorter duration of treatment. Further investigation is warranted to identify the optimal regimen and duration of treatment for CNS-TB. Complications such as hydrocephalus may be managed medically or surgically. Although outcomes have improved with effective chemotherapy and immunomodulation of disease, prompt diagnosis and treatment in the early stages of disease remain paramount to improve prognosis.

Management of central nervous system infections during an epidemic of enteroviral aseptic meningitis

1980 ◽  
Vol 96 (3) ◽  
pp. 559-563 ◽  
Author(s):  
Jonathan I. Singer ◽  
Philip R. Maur ◽  
John P. Riley ◽  
Pamela Burger Smith
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Aseptic Meningitis ◽  
Central Nervous System Infections

Diffusion imaging in pediatric central nervous system infections

2001 ◽  
Vol 43 (12) ◽  
pp. 1031-1039 ◽  
Author(s):  
J. Teixeira ◽  
R. Zimmerman ◽  
J. Haselgrove ◽  
L. Bilaniuk ◽  
J. Hunter
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Diffusion Imaging ◽  
Central Nervous System Infections

scholarly journals A neonatal mouse model of central nervous system infections caused by Coxsackievirus B5

2018 ◽  
Vol 7 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Qunying Mao ◽  
Xiaotian Hao ◽  
Yalin Hu ◽  
Ruixiao Du ◽  
Shuhui Lang ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mouse Model ◽  
Neonatal Mouse ◽  
Central Nervous System Infections
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