scholarly journals Streptococcal toxic shock syndrome caused by the dissemination of an invasive emm3/ST15 strain of Streptococcus pyogenes

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Tsuyoshi Sekizuka ◽  
Emina Nai ◽  
Tomohiro Yoshida ◽  
Shota Endo ◽  
Emi Hamajima ◽  
...  
2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Tadayoshi Ikebe ◽  
Takayuki Matsumura ◽  
Hisako Nihonmatsu ◽  
Hitomi Ohya ◽  
Rumi Okuno ◽  
...  

2005 ◽  
Vol 37 (2) ◽  
pp. 85-89 ◽  
Author(s):  
J. Gooskens ◽  
A. J. De Neeling ◽  
R. J. Willems ◽  
J. W. Van 'T Wout ◽  
E. J. Kuijper

2008 ◽  
Vol 6 (4) ◽  
pp. 0-0
Author(s):  
Valentinas Uvarovas ◽  
Igoris Šatkauskas ◽  
Tomas Sveikata ◽  
Eduardas Bartkevičius

Valentinas Uvarovas, Igoris Šatkauskas, Tomas Sveikata, Eduardas BartkevičiusVilniaus greitosios pagalbos universitetinės ligoninės Ortopedijos ir traumatologijos centras,Šiltnamių g. 29, LT-04130 VilniusEl paštas: [email protected] Šio straipsnio tikslas – aparašyti nekrozinio fascito klinikinį atvejį, pateikti literatūros apžvalgą. Nekrozinis fascitas – gyvybei pavojinga labai greitai plintanti infekcija, kuri audiniuose gali plisti žaibišku greičiu. Ji sukelia didelį mirštamumą (miršta nuo 24% iki 40% ligonių) [1, 2] bei didelį traumatizmą. Nekrozinis fascitas apima paviršines fascijas, poodinius riebalus, nervus, venas, arterijas, giliąsias fascijas. Patofiziologiškai infekcija pasireiškia fibrinoidine arteriolių koaguliacija, kuri sukelia audinių išemiją ir nekrozę.Aprašomas klinikinis atvejis, kai 44 metų pacientei uždaras kulnakaulio išnirimas komplikavosi nekrotiziniu fascitu ir streptokokiniu sepsiniu šoku su dauginiu organų nepakankamumu. Klinika pasireiškė šeštą parą po traumos, pacientė kreipėsi pakartotinai į skubiosios traumatologinės pagalbos skyrių dėl stipraus čiurnos srities skausmo. Nekrozinis fascitas ir sepsinis šokas diagnozuotas po 36 val., kai buvo paguldyta į ligoninę: skausmas išplito iki šlaunies, atsirado pūslių blauzdoje ir šlaunyje. Pacientė operuota kelis kartus: atliktos fasciotomijos, nekrektomijos, žaizdų revizija, amputuota galūnė, vėliau dėl plaštakų ir kitos pėdos gangrenavimo atliktos likusių galūnių amputacijos. Pacientė dėl sepsinio šoko ir dauginio organų nepakankamumo gydyta intensyviosios terapijos skyriuje, hemodinamika buvo palaikoma didelėmis vazopresorių dozėmis, taikyta antibiotikų terapija, hemofiltracija. Pagrindinis ligos sukėlėjas – Streptococcus pyogenes. Ligonė išgyveno, bet liko neįgali. Prognozė priklauso nuo laiku atlikto ir radikalaus chirurginio gydymo. Ankstyva diagnostika ir standartizuotas gydymas pagerintų nekrozinio fascito gydymo rezultatus vertinant mirtingumą ir galūnių išsaugojimą. Reikšminiai žodžiai: nekrozinis fascitas, Streptococcus pyogenes, toksinis šokas Streptococcus pyogenes necrotizing fascitis after closed calcaneus luxation Valentinas Uvarovas, Igoris Šatkauskas, Tomas Sveikata, Eduardas BartkevičiusOrthopedic Traumatology Center of Vilnius University Emergency Hospital,Šiltnamių str. 29, LT-04130 Vilnius, LithuaniaE-mail: [email protected] The aim of this study was to present a rare case of necrotizing fascitis and review the literature. We report a case of a 44-year-old female patient with a right closed subtalar luxation whose treatment developed necrotizing fascitis, streptococcal toxic shock syndrome and ended up with amputation of four limbs. After closed reduction of the calcaneus and immobilization in plaster cast at our emergency department and 2 days of hospitalization, the patient was referred for outpatient care. Within 6 days, due to severe pain and moderate swelling of the right ankle joint and the calf, the patient was admitted to the emergency department for the second time. In 36 hours after hospitalization, the patient developed hypotension and a severe septic situation with progressive swelling of the right calf and thigh. After the diagnosis of necrotizing fascitis had been established, the patient underwent an urgent and aggressive surgical debridement with fasciotomies of the right lower extremity. The microbiological investigation of the intraoperatively taken specimens presented group A-ß-hemolytic streptococcus. The patient survived, but despite an antibiotic therapy, intensive care support and second book operation, the amputation of the right leg was done, and the treatment ended in the amputation of the left tibia and both arms. Key words: necrotizing fascitis, Streptococcus pyogenes, streptococcal toxic shock syndrome


IDCases ◽  
2017 ◽  
Vol 9 ◽  
pp. 85-88 ◽  
Author(s):  
Tetsuya Sakai ◽  
Daisuke Taniyama ◽  
Saeko Takahashi ◽  
Morio Nakamura ◽  
Takashi Takahashi

2021 ◽  
Author(s):  
Yasha Luo ◽  
Minling Zheng ◽  
Yanyuan Chen ◽  
Chunming Gu ◽  
Lijuan Lv ◽  
...  

Abstract Background Group A streptococcal (GAS) toxic shock syndrome (TSS) is a rare invasive disease, causing a high risk of maternal and fetal mortality during pregnancy. We report a fatal case of a female caused by GAS-TSS in the third trimester of pregnancy in Guangzhou, China. Case presentation: The patient is a 33-year-old female who presented at 37 weeks’ gestation with a history of three hours fever. She underwent an emergency cesarean section due to fetal bradycardia. The neonate survived after an aggressive anti-infection treatment. However, the patient’s condition deteriorated rapidly after the operation and the patient died of disseminated intravascular coagulation and septic shock within 24h after admission. She was finally diagnosed with GAS-TSS. The GAS strains were isolated from two bottles of blood cultures, which confirmed as Streptococcus pyogenes by 16S gene sequencing and identified as serotype M1 by molecular typing. Conclusions Dramatical clinical picture and laboratory characters of the pregnant woman presented here might help improve clinicians' awareness and recognition of Streptococcus pyogenes, which could be of great importance for the early diagnosis of GAS- TSS in pregnancy.


Author(s):  
Duane Newton ◽  
Anna Norrby-Teglund ◽  
Allison McGeer ◽  
Donald E. Low ◽  
Patrick M. Schlievert ◽  
...  

2014 ◽  
Vol 63 (4) ◽  
pp. 504-507 ◽  
Author(s):  
Katsuaki Masuno ◽  
Ryo Okada ◽  
Yan Zhang ◽  
Masanori Isaka ◽  
Ichiro Tatsuno ◽  
...  

Streptococcal toxic shock syndrome (STSS) is a re-emerging infectious disease in many developed countries. Recent studies have suggested that mutations in CovRS, a two-component regulatory system in Streptococcus pyogenes, play important roles in the pathogenesis of STSS. However, in vivo evidence of the significance of CovRS in human infections has not been fully demonstrated. We investigated five S. pyogenes strains isolated simultaneously from the pharynx, sputum, knee joint, cerebrospinal fluid and blood of a single STSS patient. All were emm89-type strains, and multilocus sequence typing (MLST) analysis revealed that the strains of pharynx and blood were isogenic. The growth rates of the strains from pharynx and sputum were faster than those of the other strains. Protein profiles of the culture supernatants of strains from the pharynx and sputum were also different from those of the other strains. Sequence analyses revealed that strains from the knee joint, cerebrospinal fluid and blood contained a single nucleotide difference in the covS coding region, resulting in one amino acid change, compared with the other strains. Introduction of a plasmid containing the covS gene from the pharynx strain to the blood strain increased the production of SpeB protein. This suggests that the one amino acid alteration in CovS was relevant to pathogenesis. This report supports the idea that mutated CovS plays important roles in vivo in the dissemination of S. pyogenes from the upper respiratory tract of human to aseptic tissues such as blood and cerebrospinal fluid.


Praxis ◽  
2005 ◽  
Vol 94 (40) ◽  
pp. 1569-1574
Author(s):  
Rafeiner ◽  
Templeton ◽  
Vonesch

Wir berichten über eine 84-jährige Patientin mit starken Unterschenkelschmerzen rechts und Zeichen einer tiefen 2-Etagen-Venenthrombose. Acht Stunden nach Eintritt manifestierte sich prätibial eine kutane Blasenbildung, welche in der Folge hämorrhagisch tingiert imponierte mit spontaner Entleerung seröser Flüssigkeit. Im weiteren Verlauf kam eine weitere Blasenbildung am Oberschenkel hinzu. Die Patientin verstarb 33 Stunden nach Eintritt unter dem Bild eines streptococcal toxic shock syndrome. Letzteres entstand im Rahmen einer nekrotisierenden Fasziitis. Aus dem kultivierten Blut und dem Sekret der Bulla wuchsen Streptococcus pyogenes (Gruppe A). Wir diskutieren die klinische Präsentation der nekrotisierenden Fasziitis mit dem Leitsymptom des massiven Schmerzes, deren Diagnostik und Therapie.


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