scholarly journals Scalp eschar and neck lymphadenopathy by Rickettsia slovaca after Dermacentor marginatus tick bite case report: multidisciplinary approach to a tick-borne disease

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Giulia Barlozzari ◽  
Federico Romiti ◽  
Maurizio Zini ◽  
Adele Magliano ◽  
Claudio De Liberato ◽  
...  
Keyword(s):  
Multidisciplinary Approach ◽  
Serological Test ◽  
Spotted Fever ◽  
Cervical Lymphadenopathy ◽  
Clinical Findings ◽  
Tick Bite ◽  
Spotted Fever Group ◽  
Dermacentor Marginatus ◽  
Rickettsia Slovaca ◽  
Tick Borne Disease

Abstract Background Scalp Eschar and Neck LymphAdenopathy after Tick bite is a zoonotic non-pathogen-specific disease most commonly due to Rickettsia slovaca and Rickettsia raoultii. Diagnosis is mostly based only on epidemiological and clinical findings, without serological or molecular corroboration. We presented a clinical case in which diagnosis was supported by entomological identification and by R. slovaca DNA amplifications from the tick vector. Case presentation A 6-year-old child presented with asthenia, scalp eschar and supraclavicular and lateral-cervical lymphadenopathy. Scalp Eschar and Neck LymphAdenopathy After Tick bite syndrome following a Dermacentor marginatus bite was diagnosed. Serological test on serum revealed an IgG titer of 1:1024 against spotted fever group rickettsiae, polymerase chain reaction assays on tick identified Rickettsia slovaca. Patient was successfully treated with doxycycline for 10 days. Conclusions A multidisciplinary approach including epidemiological information, clinical evaluations, entomological identification and molecular investigations on tick, enabled proper diagnosis and therapy.

scholarly journals Dermacentor marginatus and Dermacentor reticulatus, and Their Infection by SFG Rickettsiae and Francisella-Like Endosymbionts, in Mountain and Periurban Habitats of Northwestern Italy

2020 ◽  
Vol 7 (4) ◽  
pp. 157
Author(s):  
Aitor Garcia-Vozmediano ◽  
Giorgia Giglio ◽  
Elisa Ramassa ◽  
Fabrizio Nobili ◽  
Luca Rossi ◽  
...  
Keyword(s):  
Wild Boar ◽  
Current Distribution ◽  
Spotted Fever ◽  
Dermacentor Reticulatus ◽  
Spotted Fever Group ◽  
Dermacentor Marginatus ◽  
Rickettsia Slovaca ◽  
The Alps ◽  
Zoonotic Bacteria ◽  
Rickettsial Diseases

We investigated the distribution of Dermacentor spp. and their infection by zoonotic bacteria causing SENLAT (scalp eschar neck lymphadenopathy) in Turin province, northwestern Italy. We collected ticks in a mountain and in a periurban park, from vegetation and different animal sources, and we sampled tissues from wild boar. Dermacentor marginatus (n = 121) was collected in both study areas, on vegetation, humans, and animals, while D. reticulatus (n = 13) was exclusively collected on wild boar from the periurban area. Rickettsia slovaca and Candidatus Rickettsia rioja infected 53.1% of the ticks, and R. slovaca was also identified in 11.3% of wild boar tissues. Bartonella spp. and Francisella tularensis were not detected, however, Francisella-like endosymbionts infected both tick species (9.2%). Our findings provide new insights on the current distribution of Dermacentor spp. and their infection with a spotted-fever group rickettsiae in the Alps region. Wild boar seem to play a major role in their eco-epidemiology and dispersion in the study area. Although further studies are needed to assess the burden of rickettsial diseases, our results highlight the risk of contracting SENLAT infection through Dermacentor spp. bites in the region.

scholarly journals Taxonomic Relationships among Spotted Fever Group Rickettsiae as Revealed by Antigenic Analysis with Monoclonal Antibodies

1998 ◽  
Vol 36 (4) ◽  
pp. 887-896 ◽  
Author(s):  
Wenbin Xu ◽  
Didier Raoult
Keyword(s):  
Monoclonal Antibodies ◽  
Phylogenetic Analyses ◽  
Spotted Fever ◽  
Rickettsia Conorii ◽  
Spotted Fever Group ◽  
Antigenic Analysis ◽  
Taxonomic Relationships ◽  
Rickettsia Africae ◽  
Rickettsia Slovaca ◽  
Rickettsia Sibirica

The spotted fever group (SFG) is made up of more than 20 different rickettsial species and strains. Study of the taxonomic relationships among the group has been attempted by phenotypic, genotypic, and phylogenetic analyses. In this study, we determined taxonomic relationships among the SFG rickettsiae by comparative analysis of immunogenic epitopes reactive against a panel of monoclonal antibodies. A total of 98 monoclonal antibodies, which were directed against epitopes on the major immunodominant proteins or on the lipopolysaccharide-like antigens of strains of Rickettsia africae, Rickettsia conorii, Rickettsia massiliae, Rickettsia akari, Rickettsia sibirica, and Rickettsia slovaca, were used in the study. The distribution and expression of the epitopes among 29 SFG rickettsiae and Rickettsia bellii were assessed by determination of reaction titers in a microimmunofluorescence assay. The results were scored as numerical taxonomic data, and cluster analysis was used to construct a dendrogram. The architecture of this dendrogram was consistent with previous taxonomic studies, and the implications of this and other findings are discussed.

Spotted fever group rickettsiae identified in Dermacentor marginatus and Ixodes ricinus ticks in Algeria

2012 ◽  
Vol 3 (5-6) ◽  
pp. 380-381 ◽  
Author(s):  
Tahar Kernif ◽  
Dalila Messaoudene ◽  
Soraya Ouahioune ◽  
Philippe Parola ◽  
Didier Raoult ◽  
...  
Keyword(s):  
Ixodes Ricinus ◽  
Spotted Fever ◽  
Spotted Fever Group ◽  
Dermacentor Marginatus ◽  
Spotted Fever Group Rickettsiae ◽  
Ixodes Ricinus Ticks

African tick-bite fever: a new spotted fever group rickettsiosis under an old name

The Lancet ◽  
1992 ◽  
Vol 340 (8825) ◽  
pp. 982-983 ◽  
Author(s):  
Patrick Kelly ◽  
Linda Matthewman ◽  
Lorenza Beati ◽  
Didier Raoult ◽  
Peter Mason ◽  
...  
Keyword(s):  
Spotted Fever ◽  
Tick Bite ◽  
Spotted Fever Group ◽  
African Tick Bite Fever ◽  
Tick Bite Fever

scholarly journals Spotted fever group Rickettsiae in Dermacentor marginatus from wild boars in Italy

2020 ◽  
Author(s):  
Giovanni Sgroi ◽  
Roberta Iatta ◽  
Riccardo Lia ◽  
Nicola D Alessio ◽  
Ranju Manoj ◽  
...  
Keyword(s):  
Spotted Fever ◽  
Spotted Fever Group ◽  
Dermacentor Marginatus ◽  
Wild Boars ◽  
Spotted Fever Group Rickettsiae

The prevalence and clinical characteristics of tick-borne diseases at One Sentinel Hospital in Northeastern China

Parasitology ◽  
2018 ◽  
Vol 146 (2) ◽  
pp. 161-167 ◽  
Author(s):  
Hong-Bo Liu ◽  
Ran Wei ◽  
Xue-Bing Ni ◽  
Yuan-Chun Zheng ◽  
Qiu-Bo Huo ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Spotted Fever ◽  
Erythema Migrans ◽  
Northeastern China ◽  
Spotted Fever Group ◽  
Tick Abundance ◽  
Granulocytic Anaplasmosis ◽  
Indirect Immunofluorescent Assay ◽  
Tick Borne Disease ◽  
Human Infections

AbstractNortheastern China is a region of high tick abundance, multiple tick-borne pathogens and likely human infections. The spectrum of diseases caused by tick-borne pathogens has not been objectively evaluated in this region for clinical management and for comparison with other regions globally where tick-transmitted diseases are common. Based on clinical symptoms, PCR, indirect immunofluorescent assay and (or) blood smear, we identified and described tick-borne diseases from patients with recent tick bite seen at Mudanjiang Forestry Central Hospital. From May 2010 to September 2011, 42% (75/180) of patients were diagnosed with a specific tick-borne disease, including Lyme borreliosis, tick-borne encephalitis, human granulocytic anaplasmosis, human babesiosis and spotted fever group rickettsiosis. When we compared clinical and laboratory features to identify factors that might discriminate tick-transmitted infections from those lacking that evidence, we revealed that erythema migrans and neurological manifestations were statistically significantly differently presented between those with and without documented aetiologies (P< 0.001,P= 0.003). Twelve patients (6.7%, 12/180) were co-infected with two tick-borne pathogens. We demonstrated the poor ability of clinicians to identify the specific tick-borne disease. In addition, it is necessary to develop specific laboratory assays for optimal diagnosis of tick-borne diseases.

scholarly journals Molecular Detection of Spotted-Fever Group Rickettsiae in Ticks Collected from Domestic and Wild Animals in Corsica, France

Pathogens ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 138 ◽  
Author(s):  
Vincent Cicculli ◽  
Maestrini Oscar ◽  
Francois Casabianca ◽  
Natacha Villechenaud ◽  
Remi Charrel ◽  
...  
Keyword(s):  
Spotted Fever ◽  
Companion Animals ◽  
Likelihood Estimation ◽  
Ixodid Ticks ◽  
Spotted Fever Group ◽  
Wild Animals ◽  
Wild Boars ◽  
Glta Gene ◽  
Rickettsia Slovaca ◽  
Polymerase Chain

To obtain a better understanding of the current magnitude of tick-borne rickettsioses in Corsica, we used molecular methods to characterize the occurrence of Rickettsia spp. in ixodid ticks collected from domestic and wild animals. The presence of Rickettsia spp. was evaluated using real-time polymerase chain reaction targeting the gltA gene and by sequencing of gltA and ompA partial genes for species identification and phylogenetic analysis. Infection rates were calculated as the maximum-likelihood estimation (MLE) with 95% confidence intervals (CI). In total, 1117 ticks belonging to four genera (Rhipicephalus, Hyalomma, Ixodes, and Dermacentor) were collected from cattle, sheep, wild boars, and companion animals during July–August 2017 and July 2018–January 2019. Overall, Rickettsia DNA was detected in 208 of 349 pools of ticks (MLE = 25.6%, 95% CI: 22.6–28.8%). The molecular analysis revealed five different rickettsial species of the spotted-fever group (SFG). We highlighted the exclusive detection of Candidatus Ri. barbariae in R. bursa and of Ri. aeschlimanii in H. marginatum. Rickettsia slovaca was detected in D. marginatus collected from wild boars. This study provides the first evidence of the presence of Ri. monacensis in I. ricinus ticks isolated from a dog in Corsica. In conclusion, our data revealed wide dispersal of SFG Rickettsiae and their arthropod hosts in Corsica, highlighting the need for surveillance of the risk of infection for people living and/or working close to infected or infested animals.

scholarly journals Tick-borne lymphadenopathy acquired in Serbia: Report of two cases

2018 ◽  
Vol 75 (11) ◽  
pp. 1134-1137
Author(s):  
Zorica Gajinov ◽  
Tatjana Ros ◽  
Milana Ivkov-Simic ◽  
Branislava Gajic ◽  
Sonja Prcic ◽  
...  
Keyword(s):  
Spotted Fever ◽  
Disease Status ◽  
Complete Healing ◽  
Spotted Fever Group ◽  
Infectious Agents ◽  
Tick Bites ◽  
Lymph Node Enlargement ◽  
Scalp Necrosis ◽  
Rickettsia Slovaca ◽  
Font Color

Introduction. Acronym tick-borne lymphoadenoathy (TIBOLA (Dermacentor-borne necrosis erythema and lymphoadenopathy ? DEBONEL, scalp eschar associated with neck lymphoadenopathy ? SENLAT) comprises clinical diagnosis of tick-borne symptoms of cervical or occipital lymphadenopathy with inoculation eschar at the site of tick bite on scalp. Since the first description, it was proved to be associated with several infectious agents, most frequently Rickettsia slovaca, or less often other spotted fever group Rickettsiae (Rickettsia raoulti and Rickettsia rioja), and gained an emerging infectious disease status in Europe. Dermacentor ticks serve as vectors and possible natural reservoir. The course is in most cases benign and infection is limited. Doxicycline is the recommended initial treatment, both for adult and most cases in children. Case report. Two subjects who acquired the desease caused by tick bites in Vojvodina region of Serbia are presented. Both patients are females. A tick was removed from the scalp, and several days later doxicycline treatment started because of the inflammatory symptoms of lymph node enlargement. Diagnostic eschar appeared in both patients during doxicycline treatment. After a switch to ciprofloxacine, inflammatory symptoms subsided, but the complete healing of scalp necrosis took longer than one month, with residual cicatricial alopecia. Conclusion. Although rare, it is necessary to include TIBOLA in a spectrum of epidemiologic risks in cases of tick bites. <br><br><font color="red"><b> This article has been corrected. Link to the correction <u><a href="http://dx.doi.org/10.2298/VSP2007765E">10.2298/VSP2007765E</a><u></b></font>

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