Clinical outcomes of dengue virus infection in pregnant and non-pregnant women of reproductive age: a retrospective cohort study from 2016 to 2019 in Paraná, Brazil

Abstract Background The increasing number of dengue cases worldwide implies a greater exposure of at-risk groups, such as pregnant women. DENV infection during pregnancy has been increasingly associated with unfavorable outcomes, but the evolution of the disease and its clinical outcomes remain unclear. The objective of this study was to characterize dengue cases in reproductive aged women by comparing the development of the disease in pregnant and non-pregnant women. Methods A population based retrospective cohort study that used data reported in the Brazilian Mandatory Notifiable Diseases Information System from 2016 to 2019 in Paraná, Brazil. We compared sociodemographic, clinical, and laboratory variables between pregnant and non-pregnant women. Hospitalization and disease severity classification (Dengue, Dengue with warning signs, Severe Dengue) were considered outcome variables. Results The two groups had differences in the year of notification, age distribution, and region of residence. Laboratory investigation was more frequent among pregnant women, and DENV-2 prevailed in both groups. The risks of hospitalization and development of Severe Dengue were higher in pregnant women. There were no deaths observed among pregnant women. Conclusion This study identified pregnancy as a risk factor for an increase in the severity of DENV infection. It reinforces the importance of identifying early signs of complication, close monitoring, and adequate treatment for pregnant women.

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Predicting severe dengue using quantified warning signs. A retrospective cohort study

Journal of Coastal Life Medicine ◽

10.12980/jclm.3.2015j5-82 ◽

2015 ◽

Vol 3 (9) ◽

pp. 708-712

Author(s):

Gary Low Kim Kuan ◽

◽

Yong Mun Hin ◽

Isa Ridzuan Mohd ◽

◽

...

Keyword(s):

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Warning Signs ◽

Severe Dengue

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Clinical outcomes among COVID-19 patients managed with modern and traditional Siddha medicine -A retrospective cohort study, Chennai, Tamil Nadu, India, 2020

Journal of Ayurveda and Integrative Medicine ◽

10.1016/j.jaim.2021.06.010 ◽

2021 ◽

Author(s):

Ramaswamy Meenakumari ◽

Karuppiah Thangaraj ◽

Arunachalam Sundaram ◽

Malayappan Meenakshi Sundaram ◽

Ponnappan Shanmugapriya ◽

...

Keyword(s):

Cohort Study ◽

Clinical Outcomes ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Tamil Nadu

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General versus regional anaesthesia for caesarean section indicated for acute foetal distress: a retrospective cohort study

BMC Anesthesiology ◽

10.1186/s12871-021-01289-7 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Junette Arlette Mbengono Metogo ◽

Theophile Njamen Nana ◽

Brian Ajong Ngongheh ◽

Emelinda Berinyuy Nyuydzefon ◽

Christoph Akazong Adjahoung ◽

...

Keyword(s):

Cohort Study ◽

Pregnant Women ◽

Retrospective Cohort Study ◽

Medical Records ◽

Regional Anaesthesia ◽

Retrospective Cohort ◽

Statistical Significance ◽

Neonatal Resuscitation ◽

Maternal Outcomes ◽

Foetal Distress

Abstract Background Acute foetal distress (AFD) is a life-threatening foetal condition complicating 2% of all pregnancies and accounting for 8.9% of caesarean sections (CS) especially in developing nations. Despite the severity of the problem, no evidence exists as to the safest anaesthetic technique for the mother and foetus couple undergoing CS for AFD. We aimed to compare general anaesthesia (GA) versus regional (spinal and epidural) anaesthesia in terms of their perioperative maternal and foetal outcomes. Methods We carried out a retrospective cohort study by reviewing the medical records of all women who underwent CS indicated for AFD between 2015 to 2018 at the Douala General Hospital, Cameroon. Medical records of neonates were also reviewed. We sought to investigate the association between GA, and regional anaesthesia administered during CS for AFD and foetal and maternal outcomes. The threshold of statistical significance was set at 0.05. Results We enrolled the medical records of 117 pregnant women who underwent CS indicated for AFD. Their mean age and mean gestational age were 30.5 ± 4.8 years and 40 weeks respectively. Eighty-three (70.9%), 29 (24.8%) and 05 (4.3%) pregnant women underwent CS under SA, GA and EA respectively. Neonates delivered by CS under GA were more likely to have a significantly low APGAR score at both the 1st (RR = 1.93, p = 0.014) and third-minute (RR = 2.52, p = 0.012) and to be resuscitated at birth (RR = 2.15, p = 0.015). Past CS, FHR pattern on CTG didn’t affect these results in multivariate analysis. Adverse maternal outcomes are shown to be higher following SA when compared to GA. Conclusion The study infers an association between CS performed for AFD under GA and foetal morbidity. This, however, failed to translate into a difference in perinatal mortality when comparing GA vs RA. This finding does not discount the role of GA, but we emphasize the need for specific precautions like adequate anticipation for neonatal resuscitation to reduce neonatal complications associated with CS performed for AFD under GA.

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