scholarly journals Prevalence of vulvovaginal candidiasis among pregnant women in the Ho municipality, Ghana: species identification and antifungal susceptibility of Candida isolates

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Sayanika Devi Waikhom ◽  
Innocent Afeke ◽  
Grace Sefakor Kwawu ◽  
Hintermann Kobina Mbroh ◽  
George Yiadom Osei ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Species Identification ◽  
Antifungal Susceptibility ◽  
Vulvovaginal Candidiasis

scholarly journals THE PREVALENCE OF VULVOVAGINAL CANDIDIASIS IN PREGNANT WOMEN ATTENDING SEVERAL HOSPITALS IN SANA’A, YEMEN

2020 ◽  
Author(s):  
Abdulrahman Humaid ◽  
Saeed M Alghalibi ◽  
Anes Al-Mahbashi ◽  
Aml AL-Arossi ◽  
Wadhah Hassan Edrees
Keyword(s):  
Pregnant Women ◽  
Peer Review ◽  
Candida Species ◽  
Antifungal Susceptibility ◽  
Common Species ◽  
Vulvovaginal Candidiasis ◽  
University Hospital ◽  
Vaginal Candidiasis ◽  
Microbiological Methods ◽  
E Mail

Candida species are opportunistic yeasts affecting the genitourinary tract which causes the vulvovaginal candidiasis in the most female especially in developing countries. This study aims to determine the prevalence of vulvovaginal candidiasis caused by Candida species causing among pregnant women in Sana'a City, Yemen. This study was carried out at the department of microbiology of AL-Kuwait University Hospital. 250 vaginal swabs were collected and cultured on Sabouraud dextrose agar. Candida species identification and antifungal susceptibility testing were determined according to standard microbiological methods. The results showed that out of 250 samples, 63(25.2%) were positive for Candida species. It was found that the C. albicans (68.3%) was the most common species isolated followed by non-albicans species that are C. tropicalis (20.6%), C. glabrata (6.3%), and C. kefyr (4.8%). Also, it was recorded that the highest prevalence of Candida species was within group aged of 36-46 year. Susceptibility tests revealed that the most isolated species of C. andida were sensitive to nystatin (95%). miconazole was the next effective drug with 64% sensitive followed by amphotericin B (29%) and clotrimazole (24%). But only 6% of the isolates were sensitive to fluconazole. It can be concluded that the vulvovaginal candidiasis are quite common in Yemen country with a high prevalence. Also, the nystatin remains the effective agent against all isolated of Candida species. In contrast, the increase resistance of Candida species to fluconazole that commonly used antifungal is an alarming increase of vaginal candidiasis caused by antifungal-resistant Candida species. Peer Review History: UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 5.0/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Name: Dr. Hassan A.H. Al-Shamahy Affiliation: Sana'a University, Yemen E-mail: [email protected]   Name: Dr. Tamer Mohamed Ali El Habibi Affiliation: Suez Canal University, Egypt. E-mail: [email protected]   Name: Rola Jadallah Affiliation: Arab American University, Palestine E-mail: [email protected] Comments of reviewer(s): Similar Articles: AN EXHAUSTIVE STATISTIC ON CURRENT MUCOADHESIVE INTRAVAGINAL DRUG DELIVERY METHODOLOGIES TETANUS IMMUNIZATION AMONG PREGNANT WOMEN: COVERAGE RATE AND RATE OF PROTECTION AT TIME OF DELIVERY

scholarly journals Prevalence and Antifungal Susceptibility patterns of Candida Isolated on CHROMagarTMCandida at a Tertiary Referral Hospital, Eastern Uganda

2019 ◽  
pp. 1-6
Author(s):  
Watsemwa Juliet Jane ◽  
Jacob Stanley Iramiot ◽  
John Bosco Kalule
Keyword(s):  
Pregnant Women ◽  
Amphotericin B ◽  
Candida Species ◽  
Vaginal Discharge ◽  
Antifungal Susceptibility ◽  
Vulvovaginal Candidiasis ◽  
Referral Hospital ◽  
Tertiary Referral ◽  
Tertiary Referral Hospital ◽  
Eastern Uganda

Background: Pregnant women are susceptible to vaginal candidiasis and maternal vulvovaginal candidiasis is a major risk factor for colonization and/or infection of the infant. The purpose of this study was to determine the prevalence and antifungal patterns of albicans and non-albicans Candida among pregnant women attending a tertiary referral hospital. Methods: Vaginal discharge- cotton swabs were self-collected from pregnant women clinically proven to have vulvovaginal candidiasis at the antenatal clinic of a tertiary referral hospital between January and July 2018. Microscopy and culture on Sabouraud's Dextrose Agar with chloramphenicol was done on the vaginal discharge-cotton swabs. Confirmatory fungal identification was done using CHROM agarTM Candida. Antifungal susceptibility testing was carried out using the standardized Kirby Bauer method. Results: Candida were isolated from 50.81% (126/249) of the swabs  and included C. albicans (80.16%, 101/126), C. glabrata (19.05% (24/126) and C. krusei (0.79%, 1/126). Candida albicans showed resistance to amphotericin B (70.63%, 89/126), clotrimazole (11.9%, 15/126), nystatin (3.17%, 4/126), fluconazole (23.02%, 29/126), and itraconazole (17.46%, 22/126). Among the non-albican Candida species, C. glabrata showed resistance to fluconazole (100% ,24/24), amphotericin B (100% ,24/24), clotrimazole (14.29%, 18/24), nystatin (1.59%, 2/24), and itraconazole (18.25%, 23/24). C. krusei showed resistance to fluconazole (100%, 1/1), amphotericin B (100%,1/1), and itraconazole (100%, 1/1). Conclusion: The candida species commonly associated with VVC in Eastern Uganda are C. albicans C. glabrata and C. krusei. Antifungal resistance was highly prevalent among the candida isolated. The use of CHROMagarTMCandida media for identification of clinically relevant Candida should be adopted instead of conventional methods that are tedious and time consuming such that treatment is based on laboratory evidence.

scholarly journals Prevalence and Antifungal Susceptibility patterns of Candida isolated on CHROMagarTMCandida at a tertiary referral hospital, Eastern Uganda.

2019 ◽  
Author(s):  
Juliet Watsemwa ◽  
Jacob Iramiot ◽  
JOHN BOSCO KALULE
Keyword(s):  
Pregnant Women ◽  
Amphotericin B ◽  
Vaginal Discharge ◽  
Antifungal Susceptibility ◽  
Vulvovaginal Candidiasis ◽  
Referral Hospital ◽  
Vaginal Candidiasis ◽  
Dilution Method ◽  
Tertiary Referral ◽  
Tertiary Referral Hospital

Abstract Background Pregnant women are susceptible to vaginal candidiasis and maternal vulvovaginal candidiasis is a major risk factor for colonization and/or infection of the infant. The purpose of this study was to determine the prevalence and antifungal patterns of albicans and non-albicans Candida among pregnant women attending a tertiary referral hospital. Methods Vaginal discharge- cotton swabs were self-collected from pregnant women clinically proven to have vulvovaginal candidiasis at the antenatal clinic of a tertiary referral hospital between January and July 2018. Microscopy and culture on Sabouraud's Dextrose Agar with chloramphenicol was done on the vaginal discharge-cotton swabs. Confirmatory fungal identification was done using CHROM agarTM Candida. Antifungal susceptibility testing was carried out using the standardized Kirby Bauer dilution method. Results Candida were isolated from 50.81% (126/249) of the swabs and included C. albicans (80.16%, 101/126), C. glabrata (19.05% (24/126) and C. krusei (0.79%, 1/126). Of the women from whom Candida were isolated, 11.1% (14/126) were in the first trimester, 39.7% (50/126) were in the second, while 49.2% (62/126) were in the third. Of the Candida isolates, 80.16% (101/126) were C. albicans, 19.05% (24/126) were C. glabrata and 0.79% (1/126) were C. krusei. Overall, all the isolates were non-susceptible to Amphotericin B, while 60.3% (76/126), 50% (63/126), 62.7% (79/126), and 48.4% (61/126) were non-susceptible to itraconazole, fluconazole, nystatin, and clotrimazole respectively. All the non-albicans Candida were resistant to itraconazole, amphotericin B, and fluconazole. Conclusion Vulvovaginal candidiasis due to multidrug resistant C.glabrata among pregnant women will require that treatment regimes are adjusted to carter for the recurrent forms. The use of CHROMagarTMCandida media for identification of clinically relevant Candida should be adopted instead of conventional methods that are tedious and time consuming such that treatment is based on laboratory evidence.

scholarly journals Species identification and antifungal susceptibility pattern ofCandidaisolates in cases of vulvovaginal candidiasis

2016 ◽  
Vol 52 (3) ◽  
pp. 269-277 ◽  
Author(s):  
Dalia Saad ElFeky ◽  
Noha Mahmoud Gohar ◽  
Eman Ahmad El-Seidi ◽  
Mona Mahmoud Ezzat ◽  
Somaia Hassan AboElew
Keyword(s):  
Species Identification ◽  
Antifungal Susceptibility ◽  
Vulvovaginal Candidiasis ◽  
Susceptibility Pattern

Antifungal susceptibility and genotypes ofCandida albicansstrains from patients with vulvovaginal candidiasis

Mycoses ◽  
2009 ◽  
Vol 52 (1) ◽  
pp. 24-28 ◽  
Author(s):  
X. P. Liu ◽  
S. R. Fan ◽  
F. Y. Bai ◽  
J. Li ◽  
Q. P. Liao
Keyword(s):  
Antifungal Susceptibility ◽  
Vulvovaginal Candidiasis

scholarly journals Species Identification and Antifungal Susceptibility Patterns of Species Belonging to Aspergillus Section Nigri

2009 ◽  
Vol 53 (10) ◽  
pp. 4514-4517 ◽  
Author(s):  
Laura Alcazar-Fuoli ◽  
Emilia Mellado ◽  
Ana Alastruey-Izquierdo ◽  
Manuel Cuenca-Estrella ◽  
Juan L. Rodriguez-Tudela
Keyword(s):  
Phylogenetic Analysis ◽  
Species Identification ◽  
Antifungal Susceptibility ◽  
Morphological Features ◽  
Correct Classification ◽  
Paradoxical Effect ◽  
Aspergillus Section Nigri ◽  
Susceptibility Patterns ◽  
Aspergillus Section

ABSTRACT A phylogenetic analysis was performed for 34 Aspergillus strains belonging to section Nigri. Molecular methods allowed for the correct classification into three different clades (A. niger, A. tubingensis, and A. foetidus). Correlation with in vitro itraconazole susceptibility distinguished the following three profiles: susceptible, resistant, and showing a paradoxical effect. A number of different species whose morphological features resemble those of A. niger showed unusual MICs to itraconazole that have never been described for the Aspergillus genus.

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