Health related quality of life after oesophagectomy: elderly patients refer similar eating and swallowing difficulties than younger patients

Abstract Objective Half of all newly diagnosed patients with glioblastoma are > 65 years still with a poor prognosis. Preserving quality of life is of high importance. However, patient reported outcome (PRO) data in this patient group is rare. The aim was to compare health-related quality of life (HRQoL) and distress between elderly and younger patients with high-grade glioma (HGG). Methods We used baseline data of a prospective study where HGG patients were enrolled from 4 hospitals. Distress was measured using the distress thermometer (DT), HRQoL using the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (QLQ-C30) plus brain module (BN20). We compared distress and HRQoL by age (≥ 65 vs. < 65 years), gender, performance score, and time since diagnosis using multivariate linear and logistic regressions. Results A total of n = 93 (30%) out of n = 309 patients were ≥ 65 years (mean 70 years, range 65–86 years). Mean DT score of elderly patients (5.2, SD 2.6) was comparable with younger patients (4.9, SD 2.6). Elderly patients reported significantly lower global health (GHS, mean elderly vs. younger; 50.8 vs. 60.5, p = 0.003), worse physical (56.8 vs. 73.3, p < 0.001) and lower cognitive functioning (51.1 vs. 63.2, p = 0.002), worse fatigue (52.5 vs. 43.5, p = 0.042), and worse motor dysfunction (34.9 vs. 23.6, p = 0.030). KPS and not age was consistently associated with HRQoL. Conclusion Physical functioning was significantly reduced in the elderly compared with younger HGG patients, and at the same time, emotional functioning and DT scores were comparable. KPS shows a greater association with HRQoL than with calendric age in HGG patients reflecting the particular importance for adequate assessment of HRQoL and general condition in elderly patients.

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Is the loss of health‐related quality of life during renal replacement therapy lower in elderly patients than in younger patients?

Nephrology Dialysis Transplantation ◽

10.1093/ndt/16.8.1675 ◽

2001 ◽

Vol 16 (8) ◽

pp. 1675-1680 ◽

Cited By ~ 58

Author(s):

Pablo Rebollo ◽

Francisco Ortega ◽

José María Baltar ◽

Fernando Álvarez‐Ude ◽

Rafael Alvarez Navascués ◽

...

Keyword(s):

Quality Of Life ◽

Renal Replacement Therapy ◽

Elderly Patients ◽

Replacement Therapy ◽

Health Related Quality ◽

Younger Patients ◽

Related Quality ◽

Health Related

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Drooling, Swallowing Difficulties and Health Related Quality of Life in Parkinson’s Disease Patients

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18158138 ◽

2021 ◽

Vol 18 (15) ◽

pp. 8138

Author(s):

Gladis Yohana Arboleda-Montealegre ◽

Roberto Cano-de-la-Cuerda ◽

César Fernández-de-las-Peñas ◽

Carlos Sanchez-Camarero ◽

Ricardo Ortega-Santiago

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Disease Duration ◽

Health Related Quality ◽

Nonmotor Symptoms ◽

Related Quality ◽

Health Related ◽

Swallowing Difficulties

Background: Parkinson’s disease (PD) is the most common neurodegenerative disorder associated with motor and nonmotor symptoms. Drooling, one of the nonmotor symptoms, can be present in 70–80% of patients with PD. The aim of this paper is to study the characteristics of PD patients with drooling compared to those without in terms of age, gender, disease duration, stage of the disease, swallowing difficulties, and health-related quality of life; methods: a cross-sectional study was conducted. The sample was divided into two groups: PD with drooling (n = 32) and PD without drooling (n = 30). Age, gender, disease duration and Hoehn & Yahr (H & Y) stage, Sialorrhea Clinical Scale for Parkinson’s Disease (SCS-PD), the 10-item Eating Assessment Tool (EAT-10), and the 39-item Parkinson’s Disease Questionnaire (PDQ-39) were compared between groups; Results: 62 individuals with PD, 40 men and 22 women (mean age 73 ± 8 years), were included. Overall, 32 patients reported drooling, and 30 did not exhibit it. The ANCOVA found significant differences between groups for the EAT-10 score (0.83, 95% CI = 5.62–9.03; p = 0.016) and SCS-PD score (1.48, 95% CI = 0.86–6.81; p < 0.001). Analysis of the PDQ-39 scores revealed no significant differences between groups for the PDQ-39 total score (p > 0.057) and in all subscales. The inclusion of gender, age, disease duration, and H & Y as covariates did not influence the results (all p > 0.05). Conclusions: drooling is related to swallowing difficulties assessed with EAT-10 but not with health-related quality of life assessed with PDQ-39 in PD patients with drooling compared to PD patients without it. Age, gender, duration of the disease, and the H & Y state of PD patients with and without drooling seem to be similar.

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Health-related Quality of Life in Elderly Patients with Heart Failure

Scandinavian Cardiovascular Journal ◽

10.1080/14017439950141524 ◽

1999 ◽

Vol 33 (5) ◽

pp. 278-285 ◽

Cited By ~ 64

Author(s):

Charles M. J. Cline, Ronnie B. Will

Keyword(s):

Quality Of Life ◽

Heart Failure ◽

Elderly Patients ◽

Health Related Quality ◽

Patients With Heart Failure ◽

Related Quality ◽

Health Related

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Effects of Pharmacologic Therapy on Health-Related Quality of Life in Elderly patients with Atrial Fibrillation: A systematic Review of Randomized and Nonrandomized Trials

Clinical Medicine Insights Cardiology ◽

10.4137/cmc.s10628 ◽

2013 ◽

Vol 7 ◽

pp. CMC.S10628 ◽

Cited By ~ 11

Author(s):

Carl J. Pepine

Keyword(s):

Quality Of Life ◽

Atrial Fibrillation ◽

Systematic Review ◽

Elderly Patients ◽

Randomized Trials ◽

Rhythm Control ◽

Health Related Quality ◽

Related Quality ◽

Health Related

This systematic review assessed the impact of atrial fibrillation (AF) and pharmacotherapy on health-related quality of life (HRQOL) in elderly patients. Highly prevalent in the elderly, AF is associated with morbidity and symptoms affecting HRQOL. A PubMed and EMBASE search (1999-2010) was conducted using the terms atrial fibrillation, elderly, quality of life, Medicare, and Medicaid. In all, 504 articles were identified and 15 were selected (studies examining pharmacotherapy [rate or rhythm control] and HRQOL in AF patients with a mean age > 65 years). Information, including study design, cohort size, and HRQOL instruments utilized, was extracted. Five observational studies, 5 randomized trials comparing rate and rhythm control, 3 randomized trials investigating pharmacologic agents, and 2 trials examining HRQOL, depression, and anxiety were identified. Elderly AF patients had reduced HRQOL versus patients in normal sinus rhythm, particularly in domains related to physical functioning. HRQOL may be particularly affected in older AF patients. Although data do not indicate whether a pharmacologic intervention or single treatment strategy—namely rate versus rhythm control—is better at improving HRQOL, either of these strategies and many pharmacologic interventions may improve HRQOL in elderly AF patients. Based on reviewed data, an algorithm is suggested to optimize HRQOL among elderly patients.

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