scholarly journals Reduced frequency of Intravitreal methotrexate injection lowers the risk of Keratopathy in Vitreoretinal lymphoma patients

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Xian Zhou ◽  
Xianjin Zhou ◽  
Huimin Shi ◽  
Jie Lai ◽  
Qingping Wang ◽  
...  
Keyword(s):  
Reduced Frequency ◽  
Vitreoretinal Lymphoma ◽  
Intravitreal Methotrexate Injection

scholarly journals Corneal Epithelial Toxicity after Intravitreal Methotrexate Injection for Vitreoretinal Lymphoma: Clinical and In Vitro Studies

2020 ◽  
Vol 9 (8) ◽  
pp. 2672
Author(s):  
Yoon Jeong ◽  
Jin Suk Ryu ◽  
Un Chul Park ◽  
Joo Youn Oh
Keyword(s):  
Folinic Acid ◽  
Glaucoma Medication ◽  
Corneal Epithelial Cells ◽  
Cytotoxic Effects ◽  
Corneal Epithelial ◽  
Vitreoretinal Lymphoma ◽  
Corneal Toxicity ◽  
Human Corneal Epithelial Cells ◽  
Intravitreal Methotrexate Injection

Methotrexate is widely used as an intraocular chemotherapy for vitreoretinal lymphoma (VRL). Although corneal toxicity has been reported in patients after intravitreal methotrexate injections, the incidence, outcome, and mechanism of the toxicity are unclear. Herein, we performed a clinical study to evaluate the incidence, predisposing factors, and treatment outcome of corneal epitheliopathy associated with intravitreal methotrexate injection. In addition, we directly investigated cytotoxic effects and mechanisms of methotrexate in cultures of human corneal epithelial cells (CECs). Medical chart reviews revealed that corneal epitheliopathy occurred in 15 eyes (22.7%, 12 patients) out of 66 eyes (45 patients) after intravitreal methotrexate injections for treatment of VRL. The use of topical anti-glaucoma medication was significantly associated with development of corneal epitheliopathy. The epitheliopathy resolved in all patients 2.4 months after onset. In culture, methotrexate decreased the survival of CECs by inducing apoptosis, increasing oxidative stress, suppressing proliferation, and upregulating inflammatory cytokines. The addition of folinic acid significantly protected the cells from the methotrexate-induced toxicity. Hence, our results suggest that care should be taken to minimize the contact of methotrexate with corneal epithelium during injection, and folic or folinic acid supplementation might be beneficial for preventing corneal complications in patients undergoing intravitreal methotrexate injections.

Accelerating Change

2018 ◽  
Author(s):  
Erin Stewart Mauldin
Keyword(s):  
Land Use ◽  
African Americans ◽  
Labor Relations ◽  
Cotton Production ◽  
Economic Independence ◽  
Contract Negotiations ◽  
Reduced Frequency ◽  
Ecological Event ◽  
Land Use Practices ◽  
Ecological Regime

Emancipation proved to be a far-reaching ecological event. Whereas the ecological regime of slavery had reinforced extensive land-use practices, the end of slavery weakened them. Freedpeople dedicated less time to erosion control and ditching and used contract negotiations and sharecropping arrangements to avoid working in a centrally directed gang. Understandably, freedpeople preferred to direct their own labor on an individual plot of land. The eventual proliferation of share-based or tenant contracts encouraged the physical reorganization of plantations. The combination of these two progressive alterations to labor relations tragically undermined African Americans’ efforts to achieve economic independence by tightening natural limits on cotton production and reducing blacks’ access to the South’s internal provisioning economy. The cessation, or even reduced frequency, of land maintenance on farms exacerbated erosion, flooding, and crops’ susceptibility to drought.

Retinal and Choroidal Changes of Vitreoretinal Lymphoma from Active to Remission Phase after Intravitreal Rituximab

2019 ◽  
Vol 28 (4) ◽  
pp. 637-646 ◽  
Author(s):  
Maria Vittoria Cicinelli ◽  
Alessandro Marchese ◽  
Elisabetta Miserocchi ◽  
Chiara Giuffré ◽  
Luigi Berchicci ◽  
...  
Keyword(s):  
Vitreoretinal Lymphoma ◽  
Remission Phase

Rotor Wake Generated Unsteady Aerodynamic Response of a Compressor Stator

1978 ◽  
Vol 100 (4) ◽  
pp. 664-675 ◽  
Author(s):  
S. Fleeter ◽  
R. L. Jay ◽  
W. A. Bennett
Keyword(s):  
Pressure Difference ◽  
Second Harmonic ◽  
Incidence Angle ◽  
Dynamic Pressure ◽  
Pressure Differential ◽  
Phase Lag ◽  
Trailing Edge ◽  
Unsteady Pressure ◽  
Forcing Function ◽  
Reduced Frequency

An experimental investigation was conducted to determine the fluctuating pressure distribution on a stationary vane row, with the primary source of excitation being the wakes from the upstream rotor blades. This was accomplished in a large scale, low speed, single stage research compressor. The forcing function, the velocity defect created by the rotor wakes, was measured with a crossed hot-wire probe. The aerodynamic response on the vanes was measured by means of flush mounted high response dynamic pressure transducers. The dynamic data were analyzed to determine the chordwise distribution of the dynamic pressure coefficient and aerodynamic phase lag as referenced to a transverse gust at the vane leading edge. Vane suction and pressure surface data as well as the pressure difference across the vane were obtained for reduced frequency values ranging from 3.65 to 16.80 and for an incidence angle range of 35.5 deg. The pressure difference data were correlated with a state-of-the-art aerodynamic cascade transverse gust analysis. The correlation was quite good for all reduced frequency values for small values of incidence. For the more negative incidence angle data points, it was shown that a convected wake phenomena not modeled in the analysis existed. Both the first and second harmonic unsteady pressure differential magnitude data decrease in the chordwise direction. The second harmonic magnitude data attains a value very nearly zero at the vane trailing edge transducer location, while the first harmonic data is still finite, albeit small, at this location. That the magnitude of the unsteady pressure differential data approaches zero near to the trailing edge, particularly the second harmonic data which has reduced frequency values to 16.8, is significant in that it reflects upon the validity of the Kutta condition for unsteady flows.

scholarly journals Numerical analysis of high-lift configurations with oscillating flaps

2021 ◽  
Author(s):  
Johannes Ruhland ◽  
Christian Breitsamter
Keyword(s):  
Reynolds Number ◽  
Flow Separation ◽  
Separated Flow ◽  
Navier Stokes ◽  
Rotational Axis ◽  
High Lift ◽  
Hinge Point ◽  
Reduced Frequency ◽  
Flap Deflection ◽  
The Impact

AbstractThis study presents two-dimensional aerodynamic investigations of various high-lift configuration settings concerning the deflection angles of droop nose, spoiler and flap in the context of enhancing the high-lift performance by dynamic flap movement. The investigations highlight the impact of a periodically oscillating trailing edge flap on lift, drag and flow separation of the high-lift configuration by numerical simulations. The computations are conducted with regard to the variation of the parameters reduced frequency and the position of the rotational axis. The numerical flow simulations are conducted on a block-structured grid using Reynolds Averaged Navier Stokes simulations employing the shear stress transport $$k-\omega $$ k - ω turbulence model. The feature Dynamic Mesh Motion implements the motion of the oscillating flap. Regarding low-speed wind tunnel testing for a Reynolds number of $$0.5 \times 10^{6}$$ 0.5 × 10 6 the flap movement around a dropped hinge point, which is located outside the flap, offers benefits with regard to additional lift and delayed flow separation at the flap compared to a flap movement around a hinge point, which is located at 15 % of the flap chord length. Flow separation can be suppressed beyond the maximum static flap deflection angle. By means of an oscillating flap around the dropped hinge point, it is possible to reattach a separated flow at the flap and to keep it attached further on. For a Reynolds number of $$20 \times 10^6$$ 20 × 10 6 , reflecting full scale flight conditions, additional lift is generated for both rotational axis positions.

Recurrence of Primary Breast Lymphoma Presenting as Bilateral Vitreoretinal Lymphoma

2021 ◽  
pp. 1-5
Author(s):  
Karishma Habbu ◽  
Roshan George ◽  
Miguel Materin
Keyword(s):  
Brain Mri ◽  
B Cell Lymphoma ◽  
Intrathecal Chemotherapy ◽  
Primary Breast Lymphoma ◽  
Blurred Vision ◽  
Breast Lymphoma ◽  
Central Nervous System Penetration ◽  
Vitreoretinal Lymphoma ◽  
The Right ◽  
Vitreous Biopsy

<b><i>Purpose:</i></b> This report describes a case of relapsed primary breast lymphoma (PBL) presenting as vitreoretinal lymphoma (VRL). <b><i>Methods:</i></b> We describe the clinical and hematopathologic findings in a patient with relapsed PBL involving the vitreous of both eyes. <b><i>Results:</i></b> A 59-year-old woman was treated for PBL with systemic and intrathecal chemotherapy 5 years prior to presentation. Three years later, she presented to an outside clinic with blurred vision in both eyes and bilateral vitritis. She was referred to our clinic with concern for ocular lymphoma. On presentation, the patient’s best-corrected visual acuity was 20/40 in the right eye and 20/25 in the left eye with 3+ vitreous cells in the right eye and 2+ vitreous cells in the left eye. Vitreous biopsy of the right eye revealed CD5-negative/CD10-negative B-cell lymphoma cells on flow cytometry. She had no evidence of disease on brain MRI, lumbar puncture, bone marrow biopsy, or full-body CT scans. She was treated with a regimen of rituximab, methotrexate, procarbazine, and vincristine for central nervous system penetration as well as multiple intraocular injections of methotrexate and rituximab with improvement in vision and ocular inflammation bilaterally. <b><i>Conclusion:</i></b> Relapsed PBL can present as bilateral VRL.

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