scholarly journals In vivo confocal microscopy qualitative investigation of the relationships between lattice corneal dystrophy deposition and corneal nerves

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Fengjiao Zhu ◽  
Ming Li ◽  
Chun Zhang ◽  
Chan Chen ◽  
Fangwei Ying ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Laser Scanning ◽  
Corneal Dystrophy ◽  
Amyloid Deposit ◽  
Laser Scanning Confocal Microscopy ◽  
Nerve Fibers ◽  
Scanning Confocal Microscopy ◽  
Lattice Corneal Dystrophy ◽  
Corneal Nerves

Abstract Background To investigate the corneal neurotropic phenomenon in patients with lattice corneal dystrophy (LCD) with in vivo laser scanning confocal microscopy (IVCM). Methods IVCM was performed on a total of 15 patients (28 eyes) with LCD annually at a follow-up. A collection of the data was acquired to be analyzed. Results As indicated by the analysis, the LCD patients’ normal corneal stromal nerves (Grade 0) presented a decline with the prolongation of the follow-ups, corresponding to a gradual increase in grade I and II involving amyloid-wrapped nerve fibers, which demonstrated that the growing amount of amyloid deposit due to the corneal nerve invasion increased slowly over time. Conclusions The neurotropic phenomenon could increase with its severity in the corneal lesion of the patients with LCD, and also reflect the distribution of the corneal nerves, to some extent. IVCM provides a rapid, noninvasive way to observe the corneal nerves, which can be an efficient means of better understanding the development of LCD.

scholarly journals Neurotropic Grades in Lattice Corneal Dystrophy Based on in Vivo Confocal Microscopy Observation

2020 ◽  
Author(s):  
ming li ◽  
Fengjiao Zhu ◽  
Chun Zhang ◽  
Chan Chen ◽  
Fangwei Ying ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Laser Scanning ◽  
Corneal Dystrophy ◽  
Amyloid Deposit ◽  
Laser Scanning Confocal Microscopy ◽  
Nerve Fibers ◽  
Scanning Confocal Microscopy ◽  
Lattice Corneal Dystrophy ◽  
Corneal Nerves

Abstract Background: To investigate the corneal neurotropic phenomenon in patients with lattice corneal dystrophy (LCD) with in vivo laser scanning confocal microscopy (IVCM). Methods: IVCM was performed on a total of 15 patients (28 eyes) with LCD annually at a follow-up. A collection of the data was acquired to be analyzed. Results: As indicated by the analysis, the LCD patients’ normal corneal stromal nerves (Grade 0) presented a decline with the prolongation of the follow-ups, corresponding to a gradual increase in grade I and II involving amyloid-wrapped nerve fibers, which demonstrated that the growing amount of amyloid deposit due to the corneal nerve invasion increased slowly over time. Conclusions: The neurotropic phenomenon could increase with its severity in the corneal lesion of the patients with LCD, and also reflect the distribution of the corneal nerves, to some extent. IVCM provides a rapid, noninvasive way to observe the corneal nerves, which can be an efficient means of better understanding the development of LCD.

In Vivo Laser Scanning Confocal Microscopy of the Ocular Surface in Glaucoma

2014 ◽  
Vol 20 (3) ◽  
pp. 879-894 ◽  
Author(s):  
Leonardo Mastropasqua ◽  
Luca Agnifili ◽  
Rodolfo Mastropasqua ◽  
Vincenzo Fasanella ◽  
Mario Nubile ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Ocular Surface ◽  
Laser Scanning ◽  
Current Knowledge ◽  
Laser Scanning Confocal Microscopy ◽  
Cellular Level ◽  
Surgical Approaches ◽  
Imaging Method ◽  
Scanning Confocal Microscopy

AbstractOver the past decade, knowledge about the ocular surface in glaucoma has significantly increased through the use of in vivo laser scanning confocal microscopy (LSCM). This in vivo imaging method can show modifications at the cellular level induced by anti-glaucoma drugs on ocular surface structures and adnexa in the eye. High-quality images of the conjunctiva, cornea, limbus, meibomian glands, and lymphoid structures during therapy can be obtained. In addition, LSCM opened new fields of research on the patho-physiology of aqueous humor (AH) hydrodynamics in untreated, and in medically or surgically treated glaucomatous patients. In these conditions, an enhancement of the trans-scleral AH outflow contributed to clarification of the mechanism of action of different anti-glaucoma medications and surgical approaches. Finally, the use of LSCM represented a huge advance in evaluation of bleb functionality after filtration surgery, defining the hallmarks of AH filtration through the bleb-wall and distinguishing functional from nonfunctional blebs. Thus, signs seen with LSCM may anticipate clinical failure, guiding the clinician in planning the appropriate timing of the various steps in bleb management. In this review we summarize the current knowledge about in vivo LSCM of the ocular surface in glaucoma.

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