scholarly journals Application of bedside ultrasound in predicting the outcome of weaning from mechanical ventilation in elderly patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shigang Li ◽  
Zhe Chen ◽  
Weifeng Yan
Keyword(s):  
Mechanical Ventilation ◽  
Elderly Patients ◽  
Extubation Failure ◽  
Bedside Ultrasound ◽  
Weaning From Mechanical Ventilation ◽  
Rapid Shallow Breathing Index ◽  
Diaphragm Function ◽  
Successful Weaning ◽  
Shallow Breathing ◽  
Weaning Outcome

Abstract Background With the increased ageing of society, more and more elderly people are admitted to the intensive care unit, How to accurately predict whether elderly patients can successfully wean from the ventilator is more complicated. Diaphragmatic excursion (DE) and diaphragm thickening fraction (DTF) were measured by bedside ultrasound to assess diaphragm function. The lung ultrasound score (LUS) and the rapid shallow breathing index (RBSI) were used as indices of diaphragm function to predict the outcome of weaning from mechanical ventilation. The aim of this study was to examine the clinical utility of these parameters in predicting extubation success. Methods This prospective study included 101 consecutive elderly patients undergoing a trial of extubation in the ICU of Haidian Hospital between June 2017 and July 2020. Patients were divided into the successful weaning group (n = 69) and the failed weaning group (n = 32). Baseline characteristics, including RSBI, were recorded. Measurements of DE, DTF and LUS were made using ultrasound within 24 h before extubation. Results Median DE was greater in patients with extubation success than in those with extubation failure (1.64 cm vs. 0.78 cm, p = 0.001). Patients with extubation success had a greater DTF than those with extubation failure (49.48% vs. 27.85%, p = 0.001). The areas under the receiver operating curves for the RSBI, LUS, DE and DFT were 0.680, 0.764, 0.831 and 0.881, respectively. The best cut-off values for predicting successful weaning were DTF ≥ 30%, DE ≥ 1.3 cm, LUS ≤ 11, and RSBI ≤ 102. The specificity of DTF (84%) in predicting weaning outcome was higher than that of RBSI (53%), that of LUS (55%), and that of DE (62%). The sensitivity of DTF (94%) was greater than that of RBSI (85%), that of LUS (71%), and that of DE (65%). The combination of RSBI, LUS, DE, and DTF showed the highest AUC (AUC = 0.919), with a sensitivity of 96% and a specificity of 89%. Conclusions DTF has higher sensitivity and specificity for the prediction of successful weaning in elderly patients than the other parameters examined. The combination of RSBI, LUS, DE and DFT performed well in predicting weaning outcome. This has potentially important clinical application and merits further evaluation.

The Role of Diaphragmatic Rapid Shallow Breathing Index and Maximum Inspiratory Pressure in Predicting Outcome of Weaning From Mechanical Ventilation

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Galal Adel Mohamed Abd Al Rahem Al Kadi ◽  
Raham Hasan Mostafa ◽  
Omnia Mohamed Mostafa Helwa ◽  
Ahmed Fathy Ahmed Abd-Allah
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Failure ◽  
Weaning From Mechanical Ventilation ◽  
Mechanically Ventilated ◽  
Maximum Inspiratory Pressure ◽  
Rapid Shallow Breathing Index ◽  
Inspiratory Muscles ◽  
Shallow Breathing ◽  
Weaning Outcome ◽  
Rapid Shallow Breathing

Abstract Background Mechanical ventilation is the defining event of intensive care unit (ICU) management. It is a lifesaving intervention in patients with acute respiratory failure and whose spontaneous ventilation is inadequate for subsequent development of life threatening hypoxia and/or respiratory acidosis. Many physicians simply look at the patient’s ability to tolerate a spontaneous breathing trial (SBT) without distress through the respiratory rate (RR) and TV during the SBT. The RR/TV ratio, i.e., the rapid shallow breathing index (RSBI), one of the most used clinical indices to predict weaning outcome, reflects the balance between mechanical load posed on the inspiratory muscles and the inspiratory muscles ability to face it during the weaning attempt. However, RSBI was found to have both variable sensitivity and specificity for predicting weaning outcome. Although the diaphragm plays a fundamental role in generating TV in healthy subjects, if the diaphragmatic efficiency is impaired the accessory inspiratory muscles mild contribute to the ventilation for a limited period of time, for example during a SBT. However, since they are by far less efficient and more fatigable than the diaphragm, their exhaustion was likely lead to weaning failure in subsequent hours. Hence, the contribution of the accessory muscles to TV could compromise the diagnostic accuracy of the RSBI by masking the underlying diaphragmatic dysfunction. Aim of the Work To assess the accuracy of Diaphragmatic Rapid shallow breathing index and Maximum inspiratory pressure in predicting the outcome of weaning from mechanical ventilation. Patients and Methods The study was conducted at Ain Shams University Hospitals over 6 months on Patients who were mechanically ventilated for more than 48 hrs who were ready for weaning. Inclusion Criteria Patients intubated & mechanically ventilated for more than 48 hrs. Patients at their first SBT.Patients with adequate cough reflex. Patients fulfilling criteria of readiness for weaning from mechanical ventilation after resolution of cause of respiratory failure: Patients with score ranging between -1 and +1 on the Richmond Agitation and sedation scale (RASS). Exclusion criteria Age < 18 yrs. Patients with thoracotomy, pneumothorax, or pneumomediastinum. Patients with presence of flail chest or rib fractures. Patients with neuromuscular disease. Use of muscle-paralyzing agents within 48 hours before the study. History or new detection of paralysis or paradoxical movement of a single hemi diaphragm on diaphragmatic ultrasonography. Pregnant females. Unconscious noncooperative patients. Patients with intra-abdominal hypertension, Long term steroid therapy. Results I- Distribution of the studied patients regarding final outcome. II- Demographic data. III. Causes of MV. IV- Days on MV. V- Patients’ data and characteristics before start of weaning trial. VI- SBT Ventilator Breathing pattern after 30 min. VII- Study predictors. Conclusion D-RSBI is a new and promising tool that is superior to the traditional RSBI in predicting weaning outcome also MIP provides appreciated data with greater accuracy to assess inspiratory muscle strength and predicting weaning success in mechanically ventilated patients. Recommendations We could recommend the measurement of MIP and DRSBI as weaning predictors should be an integral part of evaluation of patients plan for weaning from MV. All intensivists should be acquitted with the use of U/S in the evaluation of diaphragmatic function.

scholarly journals Ventilator induced Diaphragmatic Dysfunction assessed by Ultrasonography and its impact on Weaning outcome

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
H M A Fawzy ◽  
M H M Hassan ◽  
A A M Alkholy
Keyword(s):  
Mechanical Ventilation ◽  
Operating Characteristics ◽  
Diaphragmatic Dysfunction ◽  
Rapid Shallow Breathing Index ◽  
Weaning Failure ◽  
Significant Difference ◽  
Shallow Breathing ◽  
Ventilation Modes ◽  
Weaning Outcome ◽  
Rapid Shallow Breathing

Abstract Background Ventilator induced diaphragmatic dysfunction (VIDD), as a loss of diaphragmatic force generating capacity due to the use of mechanical ventilation. Difficulties in discontinuing ventilatory support are encountered in 20–25% of mechanically ventilated patients, with a staggering 40% of time spent in the intensive care unit being devoted to weaning. M-mode ultrasonography is now an accepted qualitative method of assessing diaphragmatic motion in normal and pathological conditions. In this study, we evaluated whether diaphragmatic excursion (DE) as measured by M-mode sonography can be a predictor of weaning and diagnosis of VIDD. Aim The aim of this study is to determine the presence of ventilator induced diaphragmatic dysfunction (VIDD) diagnosed by M-mode ultrasonography and its impact on weaning outcome. Methodology This study was conducted prospectively in critical care unit in Ain Shams Hospital, a university-affiliated, tertiary referral center in Cairo, Egypt. Study subjects included 78 patients between August 2017 to August 2018. who required mechanical ventilation ≥72hrs. who fulfilled the spontaneous breath trial (SBT) criteria, at the start of a 1-hr SBT, each hemidiaphragm was evaluated M-mode sonography with the patient in the supine position. Rapid shallow Breathing index (RSBI) was simultaneously calculated at the bedside. Ultrasonographic Diaphragmatic Dysfunction (DD) was diagnosed if an Diaphragmatic Excursion (DE) was <10 mm or negative, the latter indicating paradoxical diaphragmatic movement. Results Diaphragmatic Dysfunction (DD) among the eligible 78 patients was 48% (n = 37). DD group had longer weaning time [39,2 (26-56) hrs. vs. 22.3 (30-16) hrs. p = 0.001) in DD vs. NDD group respectively and total ventilation time [140 (130-150) hrs. vs. 130 (120–140) hrs. p > 0.05) in DD vs. NDD group respectively. Weaning failure was (45.8% vs. 30.8%, p=0.01) in DD vs. NDD group respectively. In NDD group Rt. DE, mean 25.4 ±4.1 mm. While Lt. side was 25.3±4.6 mm, 11.25mm and 22mm (45-15) respectively. In DD group Rt. DE, mean 7.6 ±2.02mm, IQR 2.4 mm and median 8.2mm (10-1.9). While Lt. side was 9.2±0.8mm, 4.3mm and 8.9mm (9.8-5.7) respectively. The area under the receiver operating characteristics curve (ROC) of ultrasonographic criteria in predicting weaning failure was near similar to that of rapid shallow breathing index. Hypercapenic acidosis in NDD group might protect them from VIDD Conclusions DD is present in a significant percentage 48% (nearly half) of our medical ICU patients on MV ≥ 72 hrs which largely account for weaning failure. DD was associated with a significant longer weaning time, and ICU stay, with no significant difference in 30 day mortality Recommendations DE by US measurements is a valuable tool and is recommended as an adjunctive weaning index to aid prediction of weaning outcome. Evaluating the role of spontaneous ventilation modes and advanced ventilation modes as PAV and NAVA effects on decreas ing VIDD versus controlled modes.

scholarly journals Success or failure predictive indexes of extubation in renal transplants patients under mechanical ventilation – pilot study

2020 ◽  
pp. 1-7
Author(s):  
Luciana Domingues Angelo da Silva ◽  
Marcella M. Musumeci F. Almeida ◽  
Matheus Oliveira Quaresma ◽  
Talita Castro ◽  
Mariana Ares Santos ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Oxygenation Index ◽  
Extubation Failure ◽  
Inspiratory Pressure ◽  
Major Health Problem ◽  
Maximum Inspiratory Pressure ◽  
Transplant Patients ◽  
Rapid Shallow Breathing Index ◽  
Shallow Breathing ◽  
Rapid Shallow Breathing

Introduction: Currently, chronic kidney disease (CKD) is a major health problem and in the most severe conditions, kidney transplantation is an alternative treatment. However immunosuppression induced these patients to respiratory complications and endotracheal intubation. In order to assist the decision of the best time for weaning and extubation of these patients, there are predictive indexes that should be considered in preliminary assesment. Objective: To check the capacity of predictive indexes for weaning of mechanical ventilation, rapid shallow breathing index (RSBI), oxygenation rate (PaO2 /FiO2 ) and maximum inspiratory pressure (MIP) in predicting the success or extubation failure in kidney transplant patients. Methods: This study is a prospective cohort carried out with patients aged over 18, under mechanical ventilation for more than 24 hours. The patients were submitted to the Spontaneous Breathing Test, also the assessment of the Rapid Shallow Breathing Index, oxygenation index (PaO2 /FiO2 ), and maximum inspiratory pressure (MIP) and they were observed during 48 hours after to evaluate the success and extubation failure. Results: A total of 106 patients were eligible, and 20 of these were included with mean age of 46.9 ± 3.06 years and 14 of the subjects were male. Three patients showed extubation failure, and needed to have reintubation within the period of 48 hours as considered. Conclusion: The indices to predict weaning of mechanical ventilation, when within the expected normal values, seem to be able to predict extubation, with the exception of MIP that, even in cases of success, showed itself to be at levels lower than the predicted percentage.

scholarly journals CRITERIA FOR SUCCESSFUL WEANING FROM MECHANICAL VENTILATION IN CHILDREN

ScienceRise ◽  
2020 ◽  
Vol 4 ◽  
pp. 53-58
Author(s):  
Olha Filyk
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Failure ◽  
Respiratory Muscle ◽  
Maximum Amplitude ◽  
Load Level ◽  
Routine Practice ◽  
Weaning From Mechanical Ventilation ◽  
Rapid Shallow Breathing Index ◽  
Difficult Weaning ◽  
Successful Weaning

The aim of the research was to establish criteria for successful weaning from mechanical ventilation in children based on analysis of Paediatric rapid shallow breathing index, maximum amplitude of diaphragm movements, diaphragm thickening fraction and pressure support (PS), which ensure minimal respiratory muscle load, level of consciousness which ensure minimal respiratory muscle load and presence of cough and swallowing reflexes and previous unsuccessful attempts of weaning. Investigated problem: there is no consensus on the basic physiological parameters for successful extubation that have to be achieved during weaning from mechanical ventilation in children due to variability in size and degree of maturity of lungs and patients’ comorbidities. It leads to the lack of clinical justification for the routine practice of weaning in children. The main scientific results: We have established a list of causes of unsuccessful weaning depending on the function of the diaphragm in children with different types of respiratory failure. We have clarified and supplemented the list of reasons for unsuccessful weaning from mechanical ventilation depending on nutritional status and level of serum electrolytes in children. We have identified and supplemented the list of reasons for unsuccessful weaning from mechanical ventilation depending on the disorders of neurological status in children. We have supplemented the algorithm for predicting difficult weaning from mechanical ventilation in children. The area of practical use of the research results: the obtained results have to increase the rate of successful weaning in children with acute respiratory failure in pediatric intensive care units.

scholarly journals Correlation between Handgrip Strength and Rapid Shallow Breathing Index for Assessment of Weaning from Mechanical Ventilation

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Narongkorn Saiphoklang ◽  
Thanapon Keawon
Keyword(s):  
Mechanical Ventilation ◽  
Prospective Study ◽  
Handgrip Strength ◽  
Apache Ii Score ◽  
Weaning From Mechanical Ventilation ◽  
Rapid Shallow Breathing Index ◽  
Weaning Failure ◽  
Shallow Breathing ◽  
A Prospective Study ◽  
Rapid Shallow Breathing

Background. Assessment of weaning from mechanical ventilation (MV) is an important process. Rapid shallow breathing index (RSBI) is a standard tool to evaluate a patient’s readiness before the spontaneous breathing trial (SBT). Handgrip strength (HGS) is an alternative method for assessment of respiratory muscle strength. Relationship between HGS and RSBI has not been explored. This study aimed to determine the correlation between HGS and RSBI to predict successful extubation in mechanically ventilated patients. Methods. A prospective study was conducted in screened 120 patients requiring MV with tracheal intubation >48 h. HGS was performed at 48 h after intubation, 10 min before and 30 min after SBT, and 1 h after extubation. RSBI was performed at 10 min before SBT. Results. A total of 93 patients (58% men) were included in the final analysis. Mean age was 71.6 ± 15.2 years. Patients admitted in general medical wards were 84.9%. APACHE II score was 13.5 ± 4.7. Most patients were intubated from pneumonia (39.8%). Weaning failure was 6.5%. The main result shows that HGS was negatively correlated with RSBI (regression coefficient −0.571, P < 0.001 ). The equation for predicting RSBI, derived from the linear regression model, was predicted RSBI (breaths/min/L) = 39.285 + (age ∗ 0.138)–(HGS ∗ 0.571). Conclusions. HGS had significantly negative correlation with RSBI for assessment of weaning from MV. A prospective study of the HGS cutoff value is needed to investigate the difference between patients who succeeded and those who failed extubation. This trial is registered with TCTR20180323004.

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