scholarly journals Serum interleukin-17 predicts severity and prognosis in patients with community acquired pneumonia: a prospective cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chun-Mei Feng ◽  
Xin-Ming Wang ◽  
Meng-Die Li ◽  
Zheng Xu ◽  
Dong-Xu Hua ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Logistic Regression ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Community Acquired Pneumonia ◽  
Interleukin 17 ◽  
Vasoactive Agent ◽  
Severity Scores ◽  
Hospital Stays

Abstract Background Some studies previously demonstrated that interleukin-17 (IL-17) involves in pulmonary diseases progression. Nevertheless, the role of IL-17 in community-acquired pneumonia (CAP) remains unknown. This study aims to examine the correlations between serum IL-17 with the severity and prognosis in CAP patients through a prospective cohort study. Methods All 239 CAP patients were recruited. Serum IL-17 was detected by enzyme-linked immunosorbent assay (ELISA). The CAP severity was evaluated through CAP severity scores, including CURB-65, CRB-65, PSI, SMART-COP, CURXO and APACHE II. Results Serum IL-17 was gradually increased consistent with the severity of CAP. Correlative analysis suggested that serum IL-17 was associated with clinical physiologic indicators among CAP patients. Logistic regression indicated that serum IL-17 was positively related to CAP severity scores. Additionally, the prognostic outcomes were tracked among CAP patients. The levels of IL-17 on admission were significantly increased in CAP patients with ICU admission, mechanical ventilation, vasoactive agent, death and longer hospitalization days. Logistic regression analyses revealed serum higher IL-17 on admission elevated the risks of vasoactive agent usage and longer hospital stays in CAP patients. The cut-off concentrations of serum IL-17 for death, ICU admission, mechanical ventilation and ≥ 14 hospital stays were 86.80 ng/mL, 84.92 ng/mL, 84.92 ng/mL and 60.29 ng/mL respectively. Conclusions Serum IL-17 on admission is positively associated with the severity and poor prognosis among CAP patients, revealing that IL-17 may implicate in the pathological process of CAP. Therefore, serum IL-17 may become an effective biomarker for diagnosis, prognosis and therapy for CAP patients.

scholarly journals Serum IL-27 Predicts the Severity and Prognosis in Patients With Community-acquired Pneumonia: A Prospective Cohort Study

2021 ◽  
Author(s):  
Zheng Xu ◽  
Hong-Yan Liu ◽  
Chun-Mei Feng ◽  
Dong-Xu Hua ◽  
Jia-Yi Cheng ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Cohort Study ◽  
Inflammatory Cytokines ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Community Acquired Pneumonia ◽  
Enzyme Linked Immunosorbent Assay ◽  
Healthy Population ◽  
Vasoactive Agent ◽  
Severity Scores

Abstract Background: The previous studies have revealed that IL-27 was involved in the pathophysiology of pulmonary inflammatory diseases. However, the role of IL-27 in the community-acquired pneumonia (CAP) was unclear. The goal of this research was to explore the associations of serum IL-27 with the severity and prognosis among CAP patients through a prospective cohort study.Methods: The whole of 239 healthy population and 239 CAP patients were enrolled. Fasting blood samples were collected. Inflammatory cytokines were detected using enzyme linked immunosorbent assay (ELISA). Demographic characteristics and clinical information were analyzed. Results: Serum IL-27 was significantly risen in CAP patients compared with control subjects on admission. Besides, serum IL-27 was gradually increased in line with CAP severity scores among CAP patients. Analysis on relevance suggested that serum IL-27 was associated with blood routine indices, renal function, liver function, myocardial function and inflammatory cytokines. Linear regression and logistic regression revealed that serum IL-27 was positively correlated with CAP severity scores. Logistic regression demonstrated that serum IL-27 on admission was positively correlated with vasoactive agent usage and longer hospital stay during hospitalization among CAPO patients. Conclusions: Serum IL-27 is markedly and positively associated with the severity and poor prognosis among CAP patients, indicating that IL-27 may involve in the pathophysiological process of CAP. Serum IL-27 may be used as a diagnostic and prognostic biomarker for CAP patients.

scholarly journals The associations of serum S100A9 with the severity and prognosis in patients with community-acquired pneumonia: a prospective cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hong-Yan Liu ◽  
Hui-Xian Xiang ◽  
Ying Xiang ◽  
Zheng Xu ◽  
Chun-Mei Feng ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hospital Stay ◽  
Inflammatory Cytokines ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Community Acquired Pneumonia ◽  
Risk Of Death ◽  
Control Subjects ◽  
Severity Scores ◽  
Blood Routine

Abstract Background Previous studies found that S100A9 may involve in the pathophysiology of community-acquired pneumonia (CAP). However, the role of S100A9 was unclear in the CAP. The goal was to explore the correlations of serum S100A9 with the severity and prognosis of CAP patients based on a prospective cohort study. Methods A total of 220 CAP patients and 110 control subjects were recruited. Demographic and clinical data were collected. Serum S100A9 and inflammatory cytokines were measured. Results Serum S100A9 was elevated in CAP patients on admission. Serum S100A9 was gradually elevated parallelly with CAP severity scores. Additionally, inflammatory cytokines were increased and blood routine parameters were changed in CAP patients compared with control subjects. Correlation analysis found that serum S100A9 was positively associated with CAP severity scores, blood routine parameters (WBC, NLR and MON) and inflammatory cytokines. Further, logistic regression analysis demonstrated that there were positive associations between serum S100A9 and CAP severity scores. Besides, the prognosis of CAP was tracked. Serum higher S100A9 on the early stage elevated the death of risk and hospital stay among CAP patients. Conclusion Serum S100A9 is positively correlated with the severity of CAP. On admission, serum higher S100A9 elevates the risk of death and hospital stay in CAP patients, suggesting that S100A9 may exert a certain role in the pathophysiology of CAP and regard as a serum diagnostic and managing biomarker for CAP.

scholarly journals Associations of Serum S100A12 With Severity and Prognosis in Patients With Community-Acquired Pneumonia: A Prospective Cohort Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiao Jiang ◽  
Chun-Mei Huang ◽  
Chun-Mei Feng ◽  
Zheng Xu ◽  
Lin Fu ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Calcium Binding ◽  
Prospective Cohort ◽  
Elevated Serum ◽  
Community Acquired Pneumonia ◽  
High Serum ◽  
Enzyme Linked Immunosorbent Assay ◽  
Risk Of Death ◽  
Severity Scores

BackgroundPrevious studies indicated the calcium-binding protein S100A12 to be involved in the pathophysiology of pulmonary inflammatory diseases. However, the role of S100A12 has remained elusive in patients with community-acquired pneumonia (CAP). Therefore, the purpose of this prospective cohort study was to evaluate the association between serum S100A12 with severity and prognosis in CAP patients.MethodsTwo groups with either 239 CAP patients or 239 healthy controls were enrolled in our study. Fasting blood and clinical characteristics were collected. On admission, serum S100A12 was measured using enzyme-linked immunosorbent assay (ELISA).ResultsSerum S100A12 was increased in CAP patients compared to control subjects. Furthermore, serum S100A12 was elevated according to the severity of CAP. Correlative analysis suggested that the level of serum S100A12 was associated with blood routine indices, renal function markers, inflammatory cytokines and other clinical parameters among CAP patients. Additionally, linear and logistical regression analyses indicated that serum S100A12 was positively associated with CAP severity scores in CAP patients. In addition, the association of high serum S100A12 and prognosis was accessed using a follow-up research. Elevated serum S100A12 on admission increased the risk of death and hospital stay in CAP patients during hospitalization.ConclusionsElevated serum S100A12 on admission is positively associated with the severity and adverse prognosis in CAP patients, suggesting that S100A12 may involve in the pathophysiological process of CAP. The titre of serum S100A12 may be used as a biomarker for diagnosis and prognosis among CAP patients.

Risk of Hospitalization in Under-five Children With Community-Acquired Pneumonia: A Multicentric Prospective Cohort Study

2021 ◽  
Vol 58 (11) ◽  
pp. 1019-1023
Author(s):  
Javeed Iqbal Bhat ◽  
Bashir A. Charoo ◽  
Aparna Mukherjee ◽  
Ridwana Ahad ◽  
Rashmi R. Das ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Community Acquired Pneumonia ◽  
Under Five ◽  
Under Five Children

scholarly journals Multimorbidity and mortality

2018 ◽  
Vol 8 (1) ◽  
pp. 2235042X1880406 ◽  
Author(s):  
TG Willadsen ◽  
V Siersma ◽  
DR Nicolaisdóttir ◽  
R Køster-Rasmussen ◽  
DE Jarbøl ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
High Mortality ◽  
Mortality Risk ◽  
Prospective Cohort ◽  
Excess Mortality ◽  
Sensory Organs ◽  
Danish Population ◽  
Increased Risk

Background: Knowledge about prevalent and deadly combinations of multimorbidity is needed. Objective: To determine the nationwide prevalence of multimorbidity and estimate mortality for the most prevalent combinations of one to five diagnosis groups. Furthermore, to assess the excess mortality of the combination of two groups compared to the product of mortality associated with the single groups. Design: A prospective cohort study using Danish registries and including 3.986.209 people aged ≥18 years on 1 January, 2000. Multimorbidity was defined as having diagnoses from at least 2 of 10 diagnosis groups: lung, musculoskeletal, endocrine, mental, cancer, neurological, gastrointestinal, cardiovascular, kidney, and sensory organs. Logistic regression (odds ratios, ORs) and ratio of ORs (ROR) were used to study mortality and excess mortality. Results: Prevalence of multimorbidity was 7.1% in the Danish population. The most prevalent combination was the musculoskeletal–cardiovascular (0.4%), which had double the mortality (OR, 2.03) compared to persons not belonging to any of the diagnosis groups but showed no excess mortality (ROR, 0.97). The neurological–cancer combination had the highest mortality (OR, 6.35), was less prevalent (0.07%), and had no excess mortality (ROR, 0.94). Cardiovascular–lung was moderately prevalent (0.2%), had high mortality (OR, 5.75), and had excess mortality (ROR, 1.18). Endocrine–kidney had high excess mortality (ROR, 1.81) and cancer–mental had low excess mortality (ROR, 0.66). Mortality increased with the number of groups. Conclusions: All combinations had increased mortality risk with some of them having up to a six-fold increased risk. Mortality increased with the number of diagnosis groups. Most combinations did not increase mortality above that expected, that is, were additive rather than synergistic.

Women’s age and total motile normal morphology sperm count predict fecundability: a prospective cohort study

2020 ◽  
pp. bmjsrh-2020-200639
Author(s):  
Mei Ting Lam ◽  
Hang Wun Raymond Li ◽  
Ching Yin Grace Wong ◽  
William Shu Biu Yeung ◽  
Pak Chung Ho ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Sperm Count ◽  
Semen Parameters ◽  
Time To Pregnancy ◽  
Normal Morphology ◽  
Younger Age

ObjectiveThis study investigated the role of women’s age, serum anti-Müllerian hormone (AMH) level and semen parameters in predicting fecundability.MethodsThis was a prospective cohort study on couples attending for preconceptional health check. Occurrence of conception at 1 year after ceasing contraception and time to pregnancy were noted by telephone follow-up. The women’s age, serum AMH level and total motile normal morphology sperm count (TMNC) were compared between those who conceived and those who did not after 1 year; their independent predictive value on conception at 1 year was analysed by logistic regression. Among those conceiving within 1 year, Spearman’s correlations between time to pregnancy and the clinical parameters were studied.ResultsOf the 100 couples analysed, we found younger age of the women (p=0.008), higher serum AMH level (p=0.038) and higher TMNC (p=0.015) in those that conceived within 1 year. Multivariate logistic regression found that women’s age (OR 0.867, 95% CI 0.761 to 0.988, p=0.032) and TMNC (OR 1.089, 95% 1.001–1.185, p=0.047), but not serum AMH level, significantly predicted conception within 1 year. Among those that conceived within 1 year, none of the parameters analysed were correlated with time to pregnancy within 1 year.ConclusionsWomen’s age and TNMC are significant independent predictors of conception within 1 year. No parameter was shown to predict the time to pregnancy within 1 year. This finding can aid preconceptional counselling of couples who are planning for pregnancy.

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