scholarly journals Association between circulating 25-hydroxyvitamin D concentrations and hip replacement for osteoarthritis: a prospective cohort study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Sultana Monira Hussain ◽  
Yuanyuan Wang ◽  
Alicia K. Heath ◽  
Graham G. Giles ◽  
Dallas R. English ◽  
...  
Keyword(s):  
Cohort Study ◽  
Total Hip Replacement ◽  
Prospective Cohort Study ◽  
Hip Replacement ◽  
Prospective Cohort ◽  
Hip Osteoarthritis ◽  
Underlying Mechanism ◽  
Dried Blood Spots ◽  
Total Hip ◽  
Increased Risk

Abstract Background To examine the association between circulating 25(OH)D concentrations and incidence of total hip replacement for osteoarthritis in a prospective cohort study. Methods This study examined a random sample of 2651 participants in the Melbourne Collaborative Cohort Study who had 25(OH)D concentrations measured from dried blood spots collected in 1990-1994. Participants who underwent total hip replacement for osteoarthritis between January 2001 and December 2018 were identified by linking the cohort records to the Australian Orthopaedic Association National Joint Replacement Registry. Cox proportional hazard regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of total hip replacement for osteoarthritis in relation to 25(OH)D concentrations, adjusted for confounders. Results Eighty-six men and eighty-seven women had a total hip replacement for osteoarthritis. Compared with men in the lowest (1st) quartile of 25(OH)D concentration, the HR for total hip replacement was 2.32 (95% CI 1.05, 5.13) for those in the 2nd quartile, 2.77 (95% CI 1.28, 6.00) for those in the 3rd quartile, and 1.73 (95% CI 0.75, 4.02) for those in the highest quartile of 25(OH)D concentrations (p for trend 0.02). There was little evidence of an association in women. Conclusions Higher circulating 25(OH)D concentrations were associated with an increased risk of total hip replacement for osteoarthritis in men but not in women. Although the underlying mechanism warrants further investigation, our findings highlight the need to determine the optimal levels of circulating 25(OH)D to reduce the risk of hip osteoarthritis.

scholarly journals Ten year results of the collum femoris preserving total hip replacement: a prospective cohort study of seventy five patients

2013 ◽  
Vol 38 (5) ◽  
pp. 917-922 ◽  
Author(s):  
Jonathan Hutt ◽  
Ziad Harb ◽  
Ian Gill ◽  
Fadhil Kashif ◽  
John Miller ◽  
...  
Keyword(s):  
Cohort Study ◽  
Total Hip Replacement ◽  
Prospective Cohort Study ◽  
Hip Replacement ◽  
Prospective Cohort ◽  
Total Hip

scholarly journals Total hip replacement but not clinical osteoarthritis can be predicted by the shape of the hip: a prospective cohort study (CHECK)

2013 ◽  
Vol 21 (4) ◽  
pp. 559-564 ◽  
Author(s):  
R. Agricola ◽  
M. Reijman ◽  
S.M.A. Bierma-Zeinstra ◽  
J.A.N. Verhaar ◽  
H. Weinans ◽  
...  
Keyword(s):  
Cohort Study ◽  
Total Hip Replacement ◽  
Prospective Cohort Study ◽  
Hip Replacement ◽  
Prospective Cohort ◽  
Total Hip

scholarly journals Weight gain and the risk of total hip replacement a population-based prospective cohort study of 265,725 individuals

2011 ◽  
Vol 19 (7) ◽  
pp. 809-815 ◽  
Author(s):  
H. Apold ◽  
H.E. Meyer ◽  
B. Espehaug ◽  
L. Nordsletten ◽  
L.I. Havelin ◽  
...  
Keyword(s):  
Cohort Study ◽  
Weight Gain ◽  
Total Hip Replacement ◽  
Prospective Cohort Study ◽  
Hip Replacement ◽  
Prospective Cohort ◽  
Population Based ◽  
Total Hip

scholarly journals 1279 Does Multimorbidity Influence the Outcomes of Total Hip Replacement for Osteoarthritis?

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
R Ferguson ◽  
D Prieto-Alhambra ◽  
G Peat ◽  
K Jordan ◽  
J Valderas ◽  
...  
Keyword(s):  
Total Hip Replacement ◽  
Hip Replacement ◽  
Frailty Index ◽  
Hip Osteoarthritis ◽  
Practice Research ◽  
Clinical Practice Research Datalink ◽  
Total Hip ◽  
Functional Benefit ◽  
Increased Risk ◽  
The Uk

Abstract Introduction Limited data are available on the influence of multimorbidity on the outcomes of total hip replacement for patients with hip osteoarthritis, including the rate of complications and degree of functional benefit. The aim of this study was to investigate the influence of multimorbidity on the outcomes of total hip replacement in the UK. Method A cohort study was performed, with cohort comprised of all patients over 65 years with a diagnosis of hip osteoarthritis recorded in Clinical Practice Research Datalink and receipt of primary total hip replacement recorded in Hospital Episode Statistics Admitted Patient Care. Severity of multimorbidity burden was measured using four different scores (Charlson Comorbidity Index, Electronic Frailty Index, count of drugs prescribed, count of primary care interactions). The outcomes were (i) the risks of total hip replacement, assessed by serious post-operative complications within 90 days (analysed with logistic regression), and (ii) the benefits of surgery, assessed by post-operative Oxford Hip Score (OHS) and EQ-5D quality of life score (analysed with linear regression). Results 6,682 patients were included. The rate of complications was 3.2%. Patients with severe multimorbidity burden were at 1.5 to 2.5 times increased risk of complications than patients without multimorbidity. There was no clinically meaningful difference in the benefits of surgery between patients with and without multimorbidity, irrespective of the method of scoring multimorbidity. Conclusions Even for patients with severe multimorbidity burden, the potential benefits of total hip replacement for osteoarthritis remain substantial, while the increase in risk is relatively small.

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