scholarly journals Small-cell neuroendocrine carcinoma of the ileum: case report and literature review

BMC Surgery ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jong Eun Lee ◽  
Sung Hoon Hong ◽  
Hae Il Jung ◽  
Myoung Won Son ◽  
Tae Sung Ahn ◽  
...  
Keyword(s):  
Small Intestine ◽  
Case Report ◽  
Small Cell ◽  
Gi Tract ◽  
Ki 67 ◽  
Luminal Narrowing ◽  
Mesenteric Border ◽  
General Weakness ◽  
Progression Of Disease ◽  
Poorly Differentiated

Abstract Background Poorly differentiated neuroendocrine carcinomas (NECs) originating from the gastrointestinal (GI) tract are rare and very highly malignant disease with a poor prognosis. Poorly differentiated NECs most commonly arise in the esophagus and the large bowel; however, they may occur within virtually any portion of the GI tract. It is known, however, that they do not typically occur in the small intestine. Case report A 21-year-old woman visited an emergency room with acute abdominal pain that commenced 2 days prior to her presentation. Thereafter, a computed tomography (CT) scan was notable for a small-intestine perforation, and huge masses were observed in the small intestine and the mesentery. The mass that was located at the ileum site is approximately 100 cm above the ileocecal (IC) valve, and while it is located on the anti-mesenteric border and it seems that luminal narrowing had occurred, an obstruction is absent. Also, a same-nature mass is on the mesentery. The pathologic reports confirmed a small-cell-type NEC with a mass size of 7.5 × 6.5 cm. The mitotic count is up to 24/10 high-power fields (HPFs), the results of the immunohistochemical stain are positive for CD56 and synaptophysin, and the Ki-67 level is 50%. %. After the operation, she was treated with Etoposide-Cisplatin (EP) chemotheraphy. Stable disease was seen during Etoposide-Cisplatin chemotheraphy. Liver metastasis was also confirmed after chemotheraphy. Additionally, Irinotecan and cisplatin were used for 3 cycles, but progression of disease, neutropenic fever, thrombocytopenia, general weakness persisted. Eventually, she died 1 year and 6 months after surgery. Conclusion Ileum-located NECs are diagnosed very rarely. The most common locations for these tumors along the GI tract are the esophagus and the large intestine, but they can arise anywhere. The prognosis for NECs is poor due to the metastatic disease of most patients at the time of diagnosis. The role of adjuvant treatment requires further evaluation for the attainment of a better understanding of the overall treatment effect.

scholarly journals Poorly Differentiated Small-Cell-Type Neuroendocrine Carcinoma of the Prostate: A Case Report and Literature Review

2018 ◽  
Vol 11 (3) ◽  
pp. 676-681 ◽  
Author(s):  
Kishore Kumar ◽  
Rafeeq Ahmed ◽  
Chime Chukwunonso ◽  
Hassan Tariq ◽  
Masooma Niazi ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Tumor Grade ◽  
Small Cell ◽  
The Body ◽  
Neuroendocrine Cells ◽  
Cell Type ◽  
Variable Response ◽  
Ki 67 ◽  
Platinum Based Chemotherapy ◽  
Poorly Differentiated

Neuroendocrine cells are widespread throughout the body and can give rise of neuroendocrine tumors due to abnormal growth of the chromaffin cells. Neuroendocrine tumors divide into many subtypes based on tumor grade (Ki-67 index and mitotic count) and differentiation. These tumors can be further divided into secretory and nonsecretory types based on the production of peptide hormone by tumor cells. Poorly differentiated small-cell-type neuroendocrine tumors are one of the subtypes of neuroendocrine tumors. These tumors are less common; however, they tend to be locally invasive and aggressive in behavior with poor overall median survival. Treatment of the nonsecretory small-cell type is modeled to small-cell lung cancer with a regimen consisting of platinum-based chemotherapy and etoposide with variable response. Here, we present a case of poorly differentiated small-cell neuroendocrine tumor originating from the prostate.

Poorly differentiated neuroendocrine carcinoma-small cell of the gastrointestinal tract. Institutional experience

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 14142-14142 ◽  
Author(s):  
J. M. O′connor ◽  
J. P. Sade ◽  
A. Pairola ◽  
E. Domenichini ◽  
A. Cabanne ◽  
...  
Keyword(s):  
Overall Survival ◽  
Overall Response Rate ◽  
Response Rate ◽  
Small Cell ◽  
Gi Tract ◽  
Poorly Differentiated Neuroendocrine Carcinoma ◽  
Number Of Patients ◽  
Institutional Experience ◽  
Poorly Differentiated ◽  
Clinical Records

14142 Background: PDNEC-Small cell (OMS Clasification, grade III)of the GI tract are rare diseases. Small cel represent 0,1% to 1% of all GI malignancies, and are included in the group of PDNEC but: Do these group behave biologically and respond to treatment in the same way? Trying to elucidate this matter, we performed a retrospective analysis of our group of pts. with PDNEC. Methods: A database search was done. from 1997 to 2005 we found 31 pts. with PDNEC/Small cell from the GI Tract treated in our Centers. A review of the clinical records was performed with special interest in response rate and overall survival. interest. Results: 14 pts. were informed by the pathologist at diagnosis PDNEC and 17 pts. as small cell. Median age: 50 years (r 19–84). The most common primary site was Esophagus-Stomach (29%), followed by pancreas 9 pts. (29%. 9 pts.(29%) presented with metastatic disease with unknown orimary Sistemic symptoms were common. A majority of our pts. (61%) presented with overt metastases. The liver was involved in 14 pts. (61%) follow by lymph nodes in 5 (16%). The most common chemotherapy used was a combination Platinum based. Overall response rate was 43%. TTP for all pts were 7 months (95% IC 0.34–0.69). Overall survival was 12 months (95% IC 0,31–0,70). We observed differences in term of overall survival and TTP in favor of PDNEC (15 months vs 10 months and 8 vs 4 months respectively) pNS. Conclusions: PDNEC-Small cell had bad prognosis. In our Serie we found differences between both groups, although not statiscally significant (due to a low number of patients). Definitive data of treatment for the management of this group of pts. still lacks. No significant financial relationships to disclose.

A Paratesticular Localization of Desmoplastic Small Cell Tumor. A Case Report

1996 ◽  
Vol 82 (5) ◽  
pp. 497-498 ◽  
Author(s):  
Roberto Bertoldin ◽  
Nicola Drei ◽  
Giulio D'Incà ◽  
Maria Cristina Camuffo ◽  
Stefano Guazzieri
Keyword(s):  
Case Report ◽  
Small Cell ◽  
Cell Tumor ◽  
Combined Chemotherapy ◽  
Progression Of Disease

We report a case of paratesticular desmoplastic small cell tumor. In accord with the literature, the patient was subjected to treatment with combined chemotherapy, but he developed progression of disease and died 13 months later.

Adhesions of small intestine and urinary bladder to fracture callus within the pelvic canal in two dogs

2009 ◽  
Vol 22 (02) ◽  
pp. 163-165
Author(s):  
S. Yudelevitch
Keyword(s):  
Small Intestine ◽  
Case Report ◽  
Urinary Bladder ◽  
Clinical Signs ◽  
Pelvic Fractures ◽  
Pubic Bone ◽  
Fracture Callus ◽  
First Case ◽  
Luminal Narrowing ◽  
Bone Callus

SummaryIn this case report, we report on two cases of pelvic fractures with uncommon complications that resulted from adhesions of the small intestine to the fracture callus in dogs. The most likely cause of the clinical signs in the first case was adhesions between a segment of the jejunum and a coccygeal callus which resulted in luminal narrowing. This was further complicated by small obstructing trichobezoars. In case 2, which was admitted with incontinence, adhesions were found between fractured pubic bone callus and both the urinary bladder and a segment of the jejunum.

scholarly journals Primary malignant melanoma of the duodenum: a rare case report

2018 ◽  
Vol 5 (11) ◽  
pp. 3771
Author(s):  
Villalan Ramasamy ◽  
Anand Lakshmanan ◽  
Senthilkumaran Govindaraj Raman ◽  
Kannan Devigounder
Keyword(s):  
Small Intestine ◽  
Case Report ◽  
Malignant Melanoma ◽  
Rare Case ◽  
Primary Melanoma ◽  
Skin Melanoma ◽  
Gi Tract ◽  
Rare Case Report ◽  
Anorectal Region ◽  
Localized Disease

Malignant melanoma especially primary melanoma is uncommon in the gastrointestinal (GI) tract. GI melanomas are usually metastatic from skin melanoma. Anorectal region and small bowel are the most common sites of primary and metastatic GI melanoma respectively. Various theories have been put forward to explain the origin of Primary Melanoma of Small intestine. Melanomas of the GI tract can produce range of symptoms based on their location and size. Surgery is the main stay of treatment for localized disease. We reported a case of primary duodenal melanoma which was managed by surgically.

scholarly journals Gastrointestinal Perforation Due to Gastrointestinal Stromal Tumour (GIST) In Small Intestine-A Case Report

2019 ◽  
Vol 20 (2) ◽  
pp. 65-67
Author(s):  
SM lftekhar Uddeen Sagar ◽  
AMSM Sharfuzzaman ◽  
SM Nazrul Lslam ◽  
Md Mahamudul Hasan
Keyword(s):  
Small Intestine ◽  
Case Report ◽  
Gastrointestinal Stromal Tumors ◽  
Abdominal Mass ◽  
Gastrointestinal Stromal Tumour ◽  
Early Recurrence ◽  
Gi Bleeding ◽  
Gi Tract ◽  
Stromal Tumors ◽  
Small Intestinal

Gastrointestinal stromal tumors (GISTs) is a mesenchymal tumor of GI tract. Now a daysdiagnosis of GISTs is more frequent then previous due to advance diagnostic tool. GISTsusually present with abdominal mass and GI bleeding but it may also present with manyunusual pattern like obstruction, perforation. Perforation of GISTs is extremely rare presentation.We report a case of pneumoperitoneum due to perforation of small intestinal GIST.Emergency laparotomy followed by resection and end to end anastomosis was done. Aftersurgical treatment lmatinibmesylate was given for prevention of early recurrence. Journal of Surgical Sciences (2016) Vol. 20 (2) :65-67

Small Cell Carcinoma Manifesting as a Bulky Thoracic Mass in a Pregnant Woman: A Case Report

2006 ◽  
Vol 55 (5) ◽  
pp. 477
Author(s):  
In Jae Lee ◽  
Kwang Seok Eom ◽  
Seon Young Jeon ◽  
Im Kyung Hwang ◽  
Yul Lee ◽  
...  
Keyword(s):  
Case Report ◽  
Pregnant Woman ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell
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