scholarly journals Etlingera elatior Extract promotes cell death in B16 melanoma cells via down-regulation of ERK and Akt signaling pathways

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Aungkana Krajarng ◽  
Malin Chulasiri ◽  
Ramida Watanapokasin
Keyword(s):  
Cell Death ◽  
Signaling Pathways ◽  
Melanoma Cells ◽  
Akt Signaling ◽  
B16 Melanoma ◽  
Down Regulation ◽  
B16 Melanoma Cells ◽  
Etlingera Elatior

scholarly journals Elucidation of Melanogenesis-Associated Signaling Pathways Regulated by Argan Press Cake in B16 Melanoma Cells

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2697
Author(s):  
Thouria Bourhim ◽  
Myra O. Villareal ◽  
Chemseddoha Gadhi ◽  
Hiroko Isoda
Keyword(s):  
Signaling Pathways ◽  
Press Cake ◽  
Global Gene Expression ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
Dependent Manner ◽  
Melanin Biosynthesis ◽  
B16 Melanoma Cells ◽  
Pigmentary Disorders ◽  
Argan Oil

The beneficial effect on health of argan oil is recognized worldwide. We have previously reported that the cake that remains after argan oil extraction (argan press-cake or APC) inhibits melanogenesis in B16 melanoma cells in a time-dependent manner without cytotoxicity. In this study, the global gene expression profile of B16 melanoma cells treated with APC extract was determined in order to gain an understanding of the possible mechanisms of action of APC. The results suggest that APC extract inhibits melanin biosynthesis by down-regulating microphthalmia-associated transcription factor (Mitf) and its downstream signaling pathway through JNK signaling activation, and the inhibition of Wnt/β-catenin and cAMP/PKA signaling pathways. APC extract also prevented the transport of melanosomes by down-regulating Rab27a expression. These results suggest that APC may be an important natural skin whitening product and pharmacological agent used for clinical treatment of pigmentary disorders.

scholarly journals Down-regulation of Glutathione and Bcl-2 Synthesis in Mouse B16 Melanoma Cells Avoids Their Survival during Interaction with the Vascular Endothelium

2003 ◽  
Vol 278 (41) ◽  
pp. 39591-39599 ◽  
Author(s):  
Angel Ortega ◽  
Paula Ferrer ◽  
Julian Carretero ◽  
Elena Obrador ◽  
Miguel Asensi ◽  
...  
Keyword(s):  
Vascular Endothelium ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
Down Regulation ◽  
B16 Melanoma Cells

scholarly journals Constituents of Cryptotaenia japonica Inhibit Melanogenesis via CREB- and MAPK-Associated Signaling Pathways in Murine B16 Melanoma Cells

Molecules ◽  
2016 ◽  
Vol 21 (10) ◽  
pp. 1296 ◽  
Author(s):  
Zuh-Kyung Seong ◽  
Sung-Yoon Lee ◽  
Amrit Poudel ◽  
Sei-Ryang Oh ◽  
Hyeong-Kyu Lee
Keyword(s):  
Signaling Pathways ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
B16 Melanoma Cells

scholarly journals An Isoxazole Chalcone Derivative Enhances Melanogenesis in B16 Melanoma Cells via the Akt/GSK3β/β-Catenin Signaling Pathways

Molecules ◽  
2017 ◽  
Vol 22 (12) ◽  
pp. 2077 ◽  
Author(s):  
Li Yin ◽  
Chao Niu ◽  
Li-xin Liao ◽  
Jun Dou ◽  
Maidina Habasi ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
B16 Melanoma Cells ◽  
Chalcone Derivative

scholarly journals Acanthoic Acid Inhibits Melanogenesis through Tyrosinase Down-regulation and Melanogenic Gene Expression in B16 Melanoma Cells

2013 ◽  
Vol 8 (10) ◽  
pp. 1934578X1300801
Author(s):  
Weon-Jong Yoon ◽  
Young-Min Ham ◽  
Hun Seok Yoon ◽  
Wook-Jae Lee ◽  
Nam Ho Lee ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
B16 Melanoma ◽  
Down Regulation ◽  
Melanin Biosynthesis ◽  
Acanthopanax Koreanum ◽  
B16 Melanoma Cells ◽  
Whitening Agent ◽  
Rate Limiting ◽  
Acanthoic Acid

The aim of this study was to investigate the in vitro inhibitory effects of acanthoic acid (ACAN), isolated from Acanthopanax koreanum, on melanogenesis and its related enzymes such as tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 in B16 melanoma cells. We found that ACAN significantly attenuates melanin synthesis and reduces the activity of intracellular tyrosinase, the rate-limiting melanogenic enzyme. Western blot analysis showed that ACAN also decreases tyrosinase, TRP-1, and TRP-2 protein expression. In addition, ACAN significantly decreased the expression of microphthalmia-associated transcription factor (MITF), a key regulator of melanogenesis. These results indicate that ACAN effectively inhibits melanin biosynthesis through down-regulation of MITF and thus could be useful as a new skin-whitening agent.

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