scholarly journals Constraint-based perturbation analysis with cluster Newton method: a case study of personalized parameter estimations with irinotecan whole-body physiologically based pharmacokinetic model

2017 ◽  
Vol 11 (S7) ◽  
Author(s):  
Shun Asami ◽  
Daisuke Kiga ◽  
Akihiko Konagaya
Keyword(s):  
Newton Method ◽  
Perturbation Analysis ◽  
Pharmacokinetic Model ◽  
Whole Body ◽  
Physiologically Based Pharmacokinetic Model ◽  
Parameter Estimations ◽  
Physiologically Based Pharmacokinetic ◽  
Physiologically Based

scholarly journals Revisiting a physiologically based pharmacokinetic model for cocaine with a forensic scope

2019 ◽  
Vol 8 (3) ◽  
pp. 432-446
Author(s):  
María Elena Bravo-Gómez ◽  
Laura Nayeli Camacho-García ◽  
Luz Alejandra Castillo-Alanís ◽  
Miguel Ángel Mendoza-Meléndez ◽  
Alejandra Quijano-Mateos
Keyword(s):  
Pharmacokinetic Model ◽  
Pbpk Model ◽  
Whole Body ◽  
Physiologically Based Pharmacokinetic Model ◽  
Time Profiles ◽  
Physiologically Based Pharmacokinetic ◽  
Concentration Time ◽  
Physiologically Based ◽  
Permeability Rate ◽  
Different Tissues

A whole-body permeability-rate-limited physiologically based pharmacokinetic (PBPK) model for cocaine was developed with the aim to predict the concentration–time profiles of the drug in blood and different tissues in humans.

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