scholarly journals A Whole-Body Physiologically Based Pharmacokinetic Model of Gefitinib in Mice and Scale-Up to Humans

2015 ◽  
Vol 18 (1) ◽  
pp. 228-238 ◽  
Author(s):  
Youwei Bi ◽  
Jiexin Deng ◽  
Daryl J. Murry ◽  
Guohua An
Keyword(s):  
Pharmacokinetic Model ◽  
Scale Up ◽  
Whole Body ◽  
Physiologically Based Pharmacokinetic Model ◽  
Physiologically Based Pharmacokinetic ◽  
Physiologically Based

scholarly journals Revisiting a physiologically based pharmacokinetic model for cocaine with a forensic scope

2019 ◽  
Vol 8 (3) ◽  
pp. 432-446
Author(s):  
María Elena Bravo-Gómez ◽  
Laura Nayeli Camacho-García ◽  
Luz Alejandra Castillo-Alanís ◽  
Miguel Ángel Mendoza-Meléndez ◽  
Alejandra Quijano-Mateos
Keyword(s):  
Pharmacokinetic Model ◽  
Pbpk Model ◽  
Whole Body ◽  
Physiologically Based Pharmacokinetic Model ◽  
Time Profiles ◽  
Physiologically Based Pharmacokinetic ◽  
Concentration Time ◽  
Physiologically Based ◽  
Permeability Rate ◽  
Different Tissues

A whole-body permeability-rate-limited physiologically based pharmacokinetic (PBPK) model for cocaine was developed with the aim to predict the concentration–time profiles of the drug in blood and different tissues in humans.

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