Markers of MEK inhibitor resistance in low-grade serous ovarian cancer: EGFR is a potential therapeutic target

Marta Llaurado Fernandez; Amy Dawson; Joshua Hoenisch; Hannah Kim; Sylvia Bamford; Clara Salamanca; Gabriel DiMattia; Trevor Shepherd; Mattia Cremona; Bryan Hennessy; Shawn Anderson; Stanislav Volik; Colin C. Collins; David G. Huntsman; Mark S. Carey

doi:10.1186/s12935-019-0725-1

Markers of MEK inhibitor resistance in low-grade serous ovarian cancer: EGFR is a potential therapeutic target

Cancer Cell International ◽

10.1186/s12935-019-0725-1 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 12

Author(s):

Marta Llaurado Fernandez ◽

Amy Dawson ◽

Joshua Hoenisch ◽

Hannah Kim ◽

Sylvia Bamford ◽

...

Keyword(s):

Ovarian Cancer ◽

Therapeutic Target ◽

Mek Inhibitor ◽

Low Grade ◽

Serous Ovarian Cancer ◽

Potential Therapeutic Target ◽

Inhibitor Resistance

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Heterogeneous alteration of the ERBB3–MYC axis associated with MEK inhibitor resistance in a KRAS-mutated low-grade serous ovarian cancer patient

Molecular Case Studies ◽

10.1101/mcs.a004341 ◽

2019 ◽

Vol 5 (6) ◽

pp. a004341 ◽

Cited By ~ 2

Author(s):

Ilaria Colombo ◽

Swati Garg ◽

Arnavaz Danesh ◽

Jeffrey Bruce ◽

Patricia Shaw ◽

...

Keyword(s):

Ovarian Cancer ◽

Cancer Patient ◽

Ovarian Cancer Patient ◽

Mek Inhibitor ◽

Low Grade ◽

Serous Ovarian Cancer ◽

Inhibitor Resistance

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Cyclin E as a potential therapeutic target in high grade serous ovarian cancer

Gynecologic Oncology ◽

10.1016/j.ygyno.2016.07.111 ◽

2016 ◽

Vol 143 (1) ◽

pp. 152-158 ◽

Cited By ~ 40

Author(s):

J. Kanska ◽

M. Zakhour ◽

B. Taylor-Harding ◽

B.Y. Karlan ◽

W.R. Wiedemeyer

Keyword(s):

Ovarian Cancer ◽

Therapeutic Target ◽

Cyclin E ◽

High Grade ◽

Serous Ovarian Cancer ◽

Potential Therapeutic Target

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Abstract B23: CDK4/6 and MEK inhibitor combination in low-grade serous ovarian cancer cell lines

10.1158/1557-3265.ovca19-b23 ◽

2020 ◽

Author(s):

Joshua Hoenisch ◽

Hannah Kim ◽

Amy Dawson ◽

Nicole Lam ◽

Dane A. Cheasley ◽

...

Keyword(s):

Ovarian Cancer ◽

Cell Lines ◽

Cancer Cell ◽

Ovarian Cancer Cell ◽

Mek Inhibitor ◽

Cancer Cell Lines ◽

Low Grade ◽

Serous Ovarian Cancer ◽

Ovarian Cancer Cell Lines ◽

Inhibitor Combination

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Identification of FGFR4 as a Potential Therapeutic Target for Advanced-Stage, High-Grade Serous Ovarian Cancer

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-12-2736 ◽

2013 ◽

Vol 19 (4) ◽

pp. 809-820 ◽

Cited By ~ 52

Author(s):

Tarrik M. Zaid ◽

Tsz-Lun Yeung ◽

Melissa S. Thompson ◽

Cecilia S. Leung ◽

Tom Harding ◽

...

Keyword(s):

Ovarian Cancer ◽

Therapeutic Target ◽

High Grade ◽

Advanced Stage ◽

Serous Ovarian Cancer ◽

Potential Therapeutic Target

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The MEK Inhibitor in Low-Grade Serous Ovarian Cancer (MILO)/ENGOT-ov11 study: A multinational, randomized, open-label phase 3 study of binimetinib (MEK162) versus physician’s choice chemotherapy in patients with recurrent or persistent low-grade serous carcinomas of the ovary, fallopian tube, or primary peritoneum.

Journal of Clinical Oncology ◽

10.1200/jco.2014.32.15_suppl.tps5618 ◽

2014 ◽

Vol 32 (15_suppl) ◽

pp. TPS5618-TPS5618

Author(s):

Bradley J. Monk ◽

Rachel N. Grisham ◽

Christian Marth ◽

Susana N. Banerjee ◽

Felix Hilpert ◽

...

Keyword(s):

Ovarian Cancer ◽

Fallopian Tube ◽

Mek Inhibitor ◽

Low Grade ◽

Serous Ovarian Cancer ◽

Open Label ◽

Phase 3 ◽

Open Label Phase

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The MILO (MEK inhibitor in low-grade serous ovarian cancer)/ENGOT-ov11 study: A multinational, randomized, open-label phase 3 study of binimetinib (MEK162) versus physician’s choice chemotherapy in patients with recurrent or persistent low-grade serous carcinomas of the ovary, fallopian tube, or primary peritoneum.

Journal of Clinical Oncology ◽

10.1200/jco.2015.33.15_suppl.tps5610 ◽

2015 ◽

Vol 33 (15_suppl) ◽

pp. TPS5610-TPS5610 ◽

Cited By ~ 4

Author(s):

Bradley J. Monk ◽

Rachel N. Grisham ◽

Christian Marth ◽

Susana N. Banerjee ◽

Felix Hilpert ◽

...

Keyword(s):

Ovarian Cancer ◽

Fallopian Tube ◽

Mek Inhibitor ◽

Low Grade ◽

Serous Ovarian Cancer ◽

Open Label ◽

Phase 3 ◽

Open Label Phase

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725MO Phase I study of the combination of the dual RAF/MEK inhibitor VS-6766 and the FAK inhibitor defactinib: Results of efficacy in low grade serous ovarian cancer

Annals of Oncology ◽

10.1016/j.annonc.2021.08.1168 ◽

2021 ◽

Vol 32 ◽

pp. S728

Author(s):

S. Banerjee ◽

R. Grochot ◽

R. Shinde ◽

J. Lima ◽

M. Krebs ◽

...

Keyword(s):

Ovarian Cancer ◽

Phase I ◽

Phase I Study ◽

Mek Inhibitor ◽

Low Grade ◽

Serous Ovarian Cancer

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Abstract 1426: Multiomic analysis identifies CPT1A and fatty acid oxidation as a potential therapeutic target in platinum-refractory high grade serous ovarian cancer

10.1158/1538-7445.am2021-1426 ◽

2021 ◽

Author(s):

Hong Wang ◽

Dongqing Hugang ◽

Shrabanti Chowdhury ◽

Sara Savage ◽

Richard Ivey ◽

...

Keyword(s):

Ovarian Cancer ◽

Fatty Acid ◽

Fatty Acid Oxidation ◽

Therapeutic Target ◽

Acid Oxidation ◽

High Grade ◽

Serous Ovarian Cancer ◽

Potential Therapeutic Target ◽

Platinum Refractory

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Abstract A48: Anti-tumor activity of the MEK inhibitor pimasertib in combination with the PI3K/mTOR inhibitor SAR245409 in low-grade serous ovarian cancer

10.1158/1078-0432.ovca13-a48 ◽

2013 ◽

Author(s):

Sukhvinder S. Sidhu ◽

Frank Campana ◽

Coumaran Egile ◽

Karl Hsu ◽

Samantha Goodstal ◽

...

Keyword(s):

Ovarian Cancer ◽

Mtor Inhibitor ◽

Mek Inhibitor ◽

Low Grade ◽

Serous Ovarian Cancer ◽

Anti Tumor Activity

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Synergistic effect of MEK inhibitor and metformin combination in low grade serous ovarian cancer

Gynecologic Oncology ◽

10.1016/j.ygyno.2017.05.019 ◽

2017 ◽

Vol 146 (2) ◽

pp. 319-326 ◽

Cited By ~ 12

Author(s):

Ismail Mert ◽

Jasdeep Chhina ◽

Ghassan Allo ◽

Jing Dai ◽

Shelly Seward ◽

...

Keyword(s):

Ovarian Cancer ◽

Synergistic Effect ◽

Mek Inhibitor ◽

Low Grade ◽

Serous Ovarian Cancer

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