scholarly journals High cure rates and tolerability of artesunate–amodiaquine and dihydroartemisinin–piperaquine for the treatment of uncomplicated falciparum malaria in Kibaha and Kigoma, Tanzania

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Celine I. Mandara ◽  
Filbert Francis ◽  
Mercy G. Chiduo ◽  
Billy Ngasala ◽  
Renata Mandike ◽  
...  
Keyword(s):  
Falciparum Malaria ◽  
Uncomplicated Falciparum Malaria ◽  
High Cure ◽  
Cure Rates

scholarly journals Adverse Effect of Rifampin on Quinine Efficacy in Uncomplicated Falciparum Malaria

2003 ◽  
Vol 47 (5) ◽  
pp. 1509-1513 ◽  
Author(s):  
S. Pukrittayakamee ◽  
S. Prakongpan ◽  
S. Wanwimolruk ◽  
R. Clemens ◽  
S. Looareesuwan ◽  
...  
Keyword(s):  
Falciparum Malaria ◽  
Parasite Clearance ◽  
Uncomplicated Falciparum Malaria ◽  
Metabolic Clearance ◽  
Plasma Drug ◽  
Time Curve ◽  
Concentration Time ◽  
Median Area ◽  
Cure Rates ◽  
To Receive

ABSTRACT The effects of adding rifampin to quinine were assessed in adults with uncomplicated falciparum malaria. Patients were randomized to receive oral quinine either alone (n = 30) or in combination with rifampin (n = 29). Although parasite clearance times were shorter in the quinine-rifampin-treated patients (mean ± standard deviation, 70 ± 21 versus 82 ± 18 h; P = 0.023), recrudescence rates were five times higher (n = 15 of 23; 65%) than those obtained with quinine alone (n = 3 of 25; 12%), P < 0.001. Patients receiving rifampin had significantly greater conversion of quinine to 3-hydroxyquinine and consequently considerably lower concentrations of quinine in their plasma after the second day of treatment (median area under the plasma drug concentration-time curve from day zero to day 7 = 11.7 versus 47.5 μg/ml · day, P < 0.001). Rifampin significantly increases the metabolic clearance of quinine and thereby reduces cure rates. Rifampin should not be combined with quinine for the treatment of malaria, and the doses of quinine should probably be increased in patients who are already receiving rifampin treatment.

scholarly journals Efficacy of artemether-lumefantrine and artesunate-amodiaquine for treating uncomplicated falciparum malaria in children

2012 ◽  
Vol 52 (5) ◽  
pp. 260
Author(s):  
Tri Faranita ◽  
Ayodhia Pitaloka Pasaribu ◽  
Muhammad Ali ◽  
Munar Lubis ◽  
Syahril Pasaribu
Keyword(s):  
Treatment Failure ◽  
Falciparum Malaria ◽  
Controlled Trial ◽  
Parasite Clearance ◽  
Uncomplicated Falciparum Malaria ◽  
Clearance Time ◽  
Parasite Clearance Time ◽  
Fever Clearance Time ◽  
Late Treatment ◽  
Cure Rates

Background Artesunate-amodiaquine (ASAQ) has been usedas a firsdine treatment for uncomplicated faldparum malariain Indonesia since 2004. Its efficacy depends on amodiaquineresistance of the infecting parasites. Artemether-lumefantrine(AL) has been shown to be highly efficacious in treatinguncomplicated faldparum malaria in several countries. However,there have been few studies on these anti-malarial medicationsin Indonesia.Objective To compare the efficacy of AL to ASAQ for treatinguncomplicated faldparum malaria in children.Methods An open, randomized, controlled trial wasconducted in school-aged children in the Mandailing NatalRegency, North Sumatera Province, Indonesia, from Octoberto December 2010. A total of 280 pediatric, uncomplicatedfalciparum malaria patients were randomly assigned to receiveeither AL or ASAQ for 3 days. Participants were followed-up ondays 1,2,3,7, 14, 28 and 42 following the first medication dose.The outcomes noted were adequate clinical and parasitologicalresponse (ACPR), parasite reduction, parasite clearance time,fever clearance time and adverse events. Analysis was basedon intention-to-treat.Results In this study, ACPRs on day 42 were 86.4% and 90.7%for the ASAQ and AL groups, respectively (p=0.260). On days 7and 14, the AL group had higher cure rates than that of the ASAQgroup (P<0.05). Early treatment failure, late treatment failure andparasitological failure for both groups were similar. We also foundfaster parasite clearance time and higher parasite reduction in theAL group than in the ASAQ group. However, fever clearancetime was shorter in the ASAQ group. The incidence of adverseevents such as nausea, vomiting, malaise, and pruritus were similarbetween the two groups (P=0.441).Conclusion AL had higher efficacy than ASAQ for the treatment of uncomplicated falciparum malaria in children.[Paediatr rndones. 2012;52:260-6].

Patterns of Change in the Electrocardiogram after Halofantrine Treatment of Acute Uncomplicated Falciparum Malaria in Children

2000 ◽  
Vol 20 (4) ◽  
pp. 229-235
Author(s):  
A. Sowunmi ◽  
C.O. Falade ◽  
A.A. Adedeji ◽  
T.C. Happi ◽  
C.O. Sowunmi ◽  
...  
Keyword(s):  
Falciparum Malaria ◽  
Uncomplicated Falciparum Malaria

scholarly journals An evaluation of the treatment of parapsoriasis with phototherapy

2013 ◽  
Vol 88 (2) ◽  
pp. 306-308 ◽  
Author(s):  
Ida Alzira Gomes Duarte ◽  
Karen Levy Korkes ◽  
Vanessa Alice M. Amorim ◽  
Clarice Kobata ◽  
Roberta Buense ◽  
...  
Keyword(s):  
T Cell ◽  
Early Stage ◽  
Cutaneous Lymphoma ◽  
General Tendency ◽  
Cure Rate ◽  
High Cure ◽  
The Subject ◽  
Cure Rates

Whether parapsoriasis represents an early stage of T-cell cutaneous lymphoma is still the subject of controversy. We evaluated the efficacy of phototherapy in the treatment of parapsoriasis and its relation with TCCL. Patients diagnosed with parapsoriasis and treated with phototherapy PUVA or UVB-NB were selected. Between 1 to 8 years following treatment the evolution of their disease was evaluated. In 62 patients the cure rate was 79.3% and 17.2% showed improvement of the lesions. Only two patients developed full blown T-cell cutaneous lymphoma. Phototherapy is an excellent treatment for parapsoriasis, with high cure rates, regardless of the type of phototherapy employed. Of the 62 patients under study, parapsoriasis showed no general tendency to progress to T-cell cutaneous lymphoma.

scholarly journals A Randomised Controlled Trial to Assess the Efficacy of Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Falciparum Malaria in Peru

PLoS ONE ◽  
2007 ◽  
Vol 2 (10) ◽  
pp. e1101 ◽  
Author(s):  
Tanilu Grande ◽  
Andrea Bernasconi ◽  
Annette Erhart ◽  
Dioni Gamboa ◽  
Martin Casapia ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Falciparum Malaria ◽  
Controlled Trial ◽  
Uncomplicated Falciparum Malaria ◽  
Randomised Controlled
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