scholarly journals Severe orthostatic hypotension in otherwise uncomplicated Plasmodium vivax infection

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Chaisith Sivakorn ◽  
Polrat Wilairatana ◽  
Srivicha Krudsood ◽  
Marcus J. Schultz ◽  
Tachpon Techarang ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Orthostatic Hypotension ◽  
Plasmodium Vivax ◽  
Falciparum Malaria ◽  
Fluid Resuscitation ◽  
Orthostatic Intolerance ◽  
Parasite Clearance ◽  
Chain Reaction ◽  
Thai Woman ◽  
Polymerase Chain

AbstractImpaired autonomic control of postural homeostasis resulting in orthostatic hypotension has been described in falciparum malaria. However, severe orthostatic intolerance in Plasmodium vivax has been rarely reported. A case of non-immune previously healthy Thai woman presenting with P. vivax infection with well-documented orthostatic hypotension is described. In addition to oral chloroquine and intravenous artesunate, the patient was treated with fluid resuscitation and norepinephrine. During hospitalization, her haemodynamic profile revealed orthostatic hypotension persisting for another three days after microscopic and polymerase chain reaction confirmed parasite clearance. Potential causes are discussed.

scholarly journals Severe Orthostatic Hypotension in Otherwise Uncomplicated Plasmodium Vivax Infection

2020 ◽  
Author(s):  
Chaisith Sivakorn ◽  
Polrat Wilairatana ◽  
Srivicha Krudsood ◽  
Marcus J. Schultz ◽  
Tachpon Techarang ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Orthostatic Hypotension ◽  
Plasmodium Vivax ◽  
Fluid Resuscitation ◽  
Orthostatic Intolerance ◽  
Parasite Clearance ◽  
Chain Reaction ◽  
Thai Woman ◽  
Hemodynamic Profile ◽  
Polymerase Chain

Abstract Impaired autonomic control of postural homeostasis resulting in orthostatic hypotension has been described in falciparum malaria. However, severe orthostatic intolerance in Plasmodium vivax has not been previously reported. We describe a non-immune previously healthy Thai woman presenting with Plasmodium vivax infection with well-documented orthostatic hypotension. In addition to oral chloroquine and intravenous artesunate, the patient was treated with fluid resuscitation and norepinephrine. During hospitalization, her hemodynamic profile revealed orthostatic hypotension persisting for another three days after microscopic and polymerase chain reaction confirmed parasite clearance. Potential causes are discussed.

scholarly journals Missed Plasmodium falciparum and Plasmodium vivax Mixed Infections in Ethiopia Threaten Malaria Elimination

2021 ◽  
Author(s):  
Colleen M. Leonard ◽  
Hussein Mohammed ◽  
Mekonnen Tadesse ◽  
Jessica N. McCaffery ◽  
Doug Nace ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Plasmodium Falciparum ◽  
Lactate Dehydrogenase ◽  
Plasmodium Vivax ◽  
Therapeutic Efficacy ◽  
Dried Blood Spots ◽  
Mixed Infections ◽  
Efficacy Study ◽  
Chain Reaction ◽  
Polymerase Chain

Plasmodium falciparum and Plasmodium vivax are co-endemic in Ethiopia. This study investigated whether mixed infections were missed by microscopy from a 2017 therapeutic efficacy study at two health facilities in Ethiopia. All patients (N = 304) were initially classified as having single-species P. falciparum (n = 148 samples) or P. vivax infections (n = 156). Dried blood spots were tested for Plasmodium antigens by bead-based multiplex assay for pan-Plasmodium aldolase, pan-Plasmodium lactate dehydrogenase, P. vivax lactate dehydrogenase, and histidine-rich protein 2. Of 304 blood samples, 13 (4.3%) contained both P. falciparum and P. vivax antigens and were analyzed by polymerase chain reaction for species-specific DNA. Of these 13 samples, five were confirmed by polymerase chain reaction for P. falciparum/P. vivax co-infection. One sample, initially classified as P. vivax by microscopy, was found to only have Plasmodium ovale DNA. Plasmodium falciparum/P. vivax mixed infections can be missed by microscopy even in the context of a therapeutic efficacy study with multiple trained readers.

HRP2/3 mutation in recrudescent Plasmodium falciparum malaria case acquired in Ethiopia

2020 ◽  
Author(s):  
Shiraz Gefen-Halevi ◽  
Valentin Belinson ◽  
Uri Manor ◽  
Zeala Gazit ◽  
Gill Smollan ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Plasmodium Falciparum ◽  
Lactate Dehydrogenase ◽  
Falciparum Malaria ◽  
Malaria Case ◽  
Rapid Detection ◽  
Plasmodium Falciparum Malaria ◽  
Malaria Prophylaxis ◽  
Chain Reaction ◽  
Polymerase Chain

A 65-year-old Israeli working in Welkait, Ethiopia, not using malaria prophylaxis, developed fever. Malaria rapid detection test was consistent with non-falciparum malaria (plasmodium lactate dehydrogenase+/histidine-rich protein− [LDH+/HRP−]) but microscopy showed typical Plasmodium falciparum. HRP2/3 were negative by polymerase chain reaction. The patient suffered two recrudescence episodes following artemether–lumefantrine and atovaquone–proguanil treatments, and responded to mefloquine treatment.

Plasmodium vivax: Polymerase Chain Reaction Amplification Artifacts Limit the Suitability of pvgam1 as a Genetic Marker

2001 ◽  
Vol 99 (3) ◽  
pp. 175-179 ◽  
Author(s):  
Mallika Imwong ◽  
Sasithon Pukrittakayamee ◽  
Sornchai Looareesuwan ◽  
Jean Poirriez ◽  
Geoffrey Pasvol ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Plasmodium Vivax ◽  
Genetic Marker ◽  
Polymerase Chain Reaction Amplification ◽  
Chain Reaction ◽  
Reaction Amplification ◽  
Polymerase Chain

Evaluation of Imported Plasmodium falciparum Malaria Cases: The Use of Polymerase Chain Reaction in Diagnosis

2013 ◽  
Vol 47 (4) ◽  
pp. 668-676 ◽  
Author(s):  
Hayati DEMİRASLAN ◽  
Emrah ERDOĞAN ◽  
Zeynep TÜRE ◽  
Salih KUK ◽  
Süleyman YAZAR ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Plasmodium Falciparum Malaria ◽  
Chain Reaction ◽  
Polymerase Chain

scholarly journals Unusual Presentation of Vivax Malaria with Anaemia, Thrombocytopenia, Jaundice, Renal Disturbance, and Melena: A Report from Malang, a Nonendemic Area in Indonesia

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Loeki Enggar Fitri ◽  
Teguh Wahju Sardjono ◽  
Bagus Hermansyah ◽  
Didi Candradikusuma ◽  
Nicole Berens-Riha
Keyword(s):  
Polymerase Chain Reaction ◽  
Renal Failure ◽  
Plasmodium Falciparum ◽  
Plasmodium Vivax ◽  
Peripheral Blood ◽  
Vivax Malaria ◽  
18S Rrna ◽  
Chain Reaction ◽  
Blood Examination ◽  
Polymerase Chain

Most of the complications of malaria such as anaemia, thrombocytopenia, jaundice, and renal failure are commonly found inPlasmodium falciparummalaria, but the incidence of severe and complicated vivax malaria tends to be increasing. We report two cases of severePlasmodium vivaxmalaria from Malang, a nonendemic area in Indonesia. Patients exhibited anaemia, thrombocytopenia, jaundice, renal disturbance, and melena. Microscopic peripheral blood examination and amplification of parasite 18s rRNA by polymerase chain reaction showed the presence ofP. vivaxand absence ofP. falciparum. All patients responded well to antimalarial drugs.

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