LDL-cholesterol to HDL-cholesterol ratio discordance with lipid parameters and carotid intima-media thickness: a cohort study in China

It has been previously documented that carotid intima-media thickness (cIMT) is a predictor of cardiovascular disease. The aim of this study was to identify clinical parameters associated with an increased cIMT treated hypertensive women. Female patients (n=116) with essential hypertension, aged 40–65 years, were included in this study. Vascular ultrasound was performed and the patients were divided into two groups according to the values of cIMT (< or ≥0.9 mm). Patients with greater cIMT presented significantly higher systolic blood pressure and pulse pressure. Serum HDL-cholesterol was significantly lower and CRP was significantly higher in the same group. There was a significant correlation between cIMT and age (r=0.25,P=0.007), systolic blood pressure (r=0.19,P=0.009), pulse pressure (r=0.30,P=0.001), and LDL-cholesterol (r=0.19,P=0.043). cIMT was correlated to CRP (r=0.31,P=0.007) and negatively correlated to HDL-cholesterol (r=0.33,P=0.001). In logistic regression, only HDL-cholesterol, CRP, and pulse pressure were shown to be independent variables associated to increased cIMT. In conclusion, pulse pressure, HDL-cholesterol, and CRP are variables correlated with cIMT in treated hypertensive women.

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Abstract 14477: Adolescent Lipoprotein Subclass Profile: Reference Ranges, Comparison to Adult, and Association With Carotid Intima-media Thickness

Circulation ◽

10.1161/circ.142.suppl_3.14477 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

Raimund Pechlaner ◽

Nele Friedrich ◽

Anna Staudt ◽

Nina Gande ◽

Benoît Bernar ◽

...

Keyword(s):

Early Life ◽

Hdl Cholesterol ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Life Assessment ◽

Reference Ranges ◽

Lipoprotein Subclass ◽

Lipoprotein Subclasses ◽

Media Thickness ◽

Triglyceride Content

Introduction: Atherosclerosis begins in early life. Assessment of comprehensive lipoprotein subclass profiles in adolescents and their relation to atherosclerosis may enhance our understanding of the development of dyslipidemia in early life and inform early vascular prevention Hypothesis: Lipoprotein subclass profiles in adolescents are distinct from those in adults and associate with carotid intima-media thickness (cIMT). Methods: Content of lipids (cholesterol, free cholesterol, triglycerides, phospholipids) and apolipoproteins (apoB-100, apoA1, apoA2) of 17 lipoprotein subclasses (from least dense to densest: VLDL1-6, IDL, LDL1-6, HDL1-4) was measured in plasma of n=1776 14- to 19-year olds (56.6% female) and of n=3217 adults (51.5% female) by nuclear magnetic resonance. cIMT was ascertained by sonography in adolescents. Results: Adolescents compared to adults featured lower triglycerides, total, LDL, and non-HDL cholesterol, and apoB, and higher HDL cholesterol. They showed 27.2 to 60.5% lower triglyceride content of all lipoprotein subclasses and 21.7 to 50.0% lower VLDL lipid content. Concentrations of LDL-4 and LDL-5 were 40.7 to 47.3% lower, with markedly lower levels also of LDL-6 and LDL-3, but 24.3% higher HDL-1 ApoA1. In adolescents, LDL-3, LDL-4, and LDL-5 subclasses were associated with cIMT (difference in cIMT for a 1-SD higher concentration, 4.76 to 5.93μm), whereas no significant association with cIMT was observed for VLDL or HDL. Conclusions: Adolescents showed a markedly different and more favorable lipoprotein profile compared to adults. Dense LDL subclasses were the only subclasses associated with cIMT, implicating them as the potential preferred therapeutic target for primary prevention of cardiovascular disease in adolescents.

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17.CAROTID INTIMA-MEDIA THICKNESS IN A LARGE COHORT STUDY AND REALLY NORMAL SUBJECTS

Artery Research ◽

10.1016/j.artres.2009.06.031 ◽

2009 ◽

Vol 3 (3) ◽

pp. 98

Author(s):

Woo-Baek Chung ◽

Ho-Joong Youn ◽

Yun-Seok Choi ◽

Hee-Jung Hwang ◽

Jae-Beom Lee ◽

...

Keyword(s):

Cohort Study ◽

Intima Media Thickness ◽

Normal Subjects ◽

Carotid Intima Media Thickness ◽

Large Cohort ◽

Media Thickness ◽

Large Cohort Study

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Childhood metabolic syndrome, inflammation and carotid intima-media thickness. The Aboriginal Birth Cohort Study

International Journal of Cardiology ◽

10.1016/j.ijcard.2015.10.073 ◽

2016 ◽

Vol 203 ◽

pp. 32-36 ◽

Cited By ~ 11

Author(s):

Markus Juonala ◽

Gurmeet R. Singh ◽

Belinda Davison ◽

Katherine van Schilfgaarde ◽

Michael R. Skilton ◽

...

Keyword(s):

Metabolic Syndrome ◽

Cohort Study ◽

Birth Cohort ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Birth Cohort Study ◽

Media Thickness

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Effects of magnesium supplementation on carotid intima–media thickness and metabolic profiles in diabetic haemodialysis patients: a randomised, double-blind, placebo-controlled trial

British Journal Of Nutrition ◽

10.1017/s0007114519000163 ◽

2019 ◽

Vol 121 (7) ◽

pp. 809-817 ◽

Cited By ~ 5

Author(s):

Hamid Reza Talari ◽

Mehrafrouz Zakizade ◽

Alireza Soleimani ◽

Fereshteh Bahmani ◽

Amir Ghaderi ◽

...

Keyword(s):

Total Cholesterol ◽

Ldl Cholesterol ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Controlled Clinical Trial ◽

Double Blind ◽

Insulin Metabolism ◽

Double Blind Placebo ◽

Media Thickness ◽

Hs Crp

AbstractThis study evaluated the effects of Mg administration on carotid intima–media thickness (CIMT), glycaemic control and markers of cardio-metabolic risk in diabetic haemodialysis (HD) patients. This randomised, double-blind, placebo-controlled clinical trial was conducted in fifty-four diabetic HD patients. Participants were randomly divided into two groups to take either 250 mg/d Mg as magnesium oxide (n27) or placebo (n27) for 24 weeks. Mg supplementation resulted in a significant reduction in mean (P<0·001) and maximum levels of left CIMT (P=0·02) and mean levels of right CIMT (P=0·004) compared with the placebo. In addition, taking Mg supplements significantly reduced serum insulin levels (β=–9·42 pmol/l; 95% CI –14·94, –3·90;P=0·001), homoeostasis model of assessment-insulin resistance (β=–0·56; 95 % CI –0·89, –0·24;P=0·001) and HbA1c (β=–0·74 %; 95 % CI –1·10, –0·39;P<0·001) and significantly increased the quantitative insulin sensitivity check index (β=0·008; 95 % CI 0·002, 0·01;P=0·002) compared with the placebo. In addition, Mg administration led to a significant reduction in serum total cholesterol (β=–0·30 mmol/l; 95% CI –0·56, –0·04;P=0·02), LDL-cholesterol (β=–0·29 mmol/l; 95% CI –0·52, –0·05;P=0·01), high-sensitivity C-reactive protein (hs-CRP) (P<0·001) and plasma malondialdehyde (MDA) (P=0·04) and a significant rise in plasma total antioxidant capacity (TAC) levels (P<0·001) compared with the placebo. Overall, we found that taking Mg for 24 weeks by diabetic HD patients significantly improved mean and maximum levels of left and mean levels of right CIMT, insulin metabolism, HbA1c, total cholesterol and LDL-cholesterol, hs-CRP, TAC and MDA levels.

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