scholarly journals Dupilumab elicits a favorable response in type-2 inflammatory comorbidities of severe atopic dermatitis

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Eustachio Nettis ◽  
Lucia Masciopinto ◽  
Elisabetta Di Leo ◽  
Nicola De Candia ◽  
Marcello Albanesi ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Nasal Polyps ◽  
Inflammatory Diseases ◽  
Severe Atopic Dermatitis ◽  
Single Treatment ◽  
Case Presentation ◽  
History Of ◽  
Rhino Conjunctivitis ◽  
Economic Standpoint

Abstract Background This case is the first report describing rapid, successful treatment of severe atopic dermatitis (AD) and comorbid type-2 inflammatory diseases in the same patient, with dupilumab treatment, with no side-effects. Case presentation We report on effects of dupilumab in a patient with severe AD, a long-standing history of a mild, perennial allergic rhino-conjunctivitis, moderate asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). Conclusions Patients suffering from AD, asthma, allergic rhinitis and CRSwNP may be eligible for dupilumab single treatment that is possibly advantageous also from the pharmaco-economic standpoint.

In iodine-induced thyrotoxicosis, steroid therapy today could keep the surgical knife at bay

2018 ◽  
Vol 31 (5) ◽  
pp. 585-588 ◽  
Author(s):  
Rohan K. Henry ◽  
Monika Chaudhari
Keyword(s):  
Steroid Therapy ◽  
Medical Literature ◽  
Urinary Iodine ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Function Tests ◽  
Case Presentation ◽  
Total Triiodothyronine ◽  
History Of ◽  
Daily Allowance

Abstract Background: Amiodarone-induced thyrotoxicosis (AIT) type 2, characterized as a destructive thyroiditis, is well described in the medical literature; however, iodine-induced thyrotoxicosis (IIT) is not, though the latter has similar features and can be managed similarly. Case presentation: We present a 17-year-old female who presented with a history of an intermittent goiter with thyroid function tests (TFTs): thyroid-stimulating hormone (TSH)<0.015 (0.4–4 μU/mL), free thyroxine (T4)≥6 (0.7–2.1 ng/dL) and total triiodothyronine (T3) 651 (50–200 mg/dL). Thyroid antibodies were all negative. Despite methimazole therapy for 6 weeks, hyperthyroidism proved refractory to medical management. 123I scan uptake was suppressed. With hyperthyroidism being recalcitrant to therapy, a nutritional history revealed consumption of an iodine supplement containing at least 7 times the recommended daily allowance (RDA) for 5 years, contributing to the Jod-Basedow phenomenon. Urinary spot and 24-hour urinary iodine were both elevated. Though a surgical consult was obtained, surgery was cancelled once TFTs improved and then normalized with steroid therapy. The TFTs and urinary iodine levels remained normal post steroid therapy. Conclusions: We suggest that in addition to the need for a thorough nutritional history, a trial of corticosteroids should be utilized in the management of IIT which can present with findings similar to AIT type 2 which is recalcitrant to thionamide therapy. If successful, corticosteroids may delay or prevent surgical management thus avoiding possible complications with the latter approach.

scholarly journals 129 Extent and consequences of inadequate disease control among adults with a history of moderate-to-severe atopic dermatitis

2016 ◽  
Vol 136 (5) ◽  
pp. S23 ◽  
Author(s):  
W. Wei ◽  
P. Anderson ◽  
A. Gadkari ◽  
S. Blackburn ◽  
R. Moon ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Disease Control ◽  
Severe Atopic Dermatitis ◽  
History Of

scholarly journals Extent and consequences of inadequate disease control among adults with a history of moderate to severe atopic dermatitis

2017 ◽  
Vol 45 (2) ◽  
pp. 150-157 ◽  
Author(s):  
Wenhui Wei ◽  
Peter Anderson ◽  
Abhijit Gadkari ◽  
Stuart Blackburn ◽  
Rachel Moon ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Disease Control ◽  
Severe Atopic Dermatitis ◽  
History Of

scholarly journals Patients with atopic dermatitis and history of eczema herpeticum elicit herpes simplex virus–specific type 2 immune responses

2018 ◽  
Vol 141 (3) ◽  
pp. 1144-1147.e5 ◽  
Author(s):  
Stephan Traidl ◽  
Petra Kienlin ◽  
Gabriele Begemann ◽  
Lichen Jing ◽  
David M. Koelle ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Immune Responses ◽  
Eczema Herpeticum ◽  
History Of ◽  
Simplex Virus

scholarly journals Crazy-Paving: A Computed Tomographic Finding of Coronavirus Disease 2019

2020 ◽  
Vol 4 (3) ◽  
pp. 461-463
Author(s):  
Megan Gillespie ◽  
Patrick Flannery ◽  
Jessica Schumann ◽  
Nathan Dincher ◽  
Rebecca Mills ◽  
...  
Keyword(s):  
Imaging Finding ◽  
Radiographic Finding ◽  
Ground Glass ◽  
Past Medical History ◽  
Case Presentation ◽  
Computed Tomographic ◽  
Global Pandemic ◽  
Imaging Characteristics ◽  
History Of

Introduction: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2.1 COVID-19 first occurred in Wuhan, China, in December 2019, and by March 2020 COVID-19 was declared a global pandemic.1 Case Presentation: We describe a case of a 52-year-old female with past medical history of asthma, type 2 diabetes, and previous tobacco use who presented to the emergency department with dyspnea and was found to be positive for COVID-19. We discuss the computed tomographic finding of “crazy-paving” pattern in the patient’s lungs and the significance of this finding in COVID-19 patients. Discussion: Emergency providers need to be aware of the different imaging characteristics of various stages of COVID-19 to appropriately treat, isolate, and determine disposition of COVID-19 infected patients. Ground-glass opacities are the earliest and most common imaging finding for COVID-19.2-4 Crazy-paving pattern is defined as thickened interlobular septa and intralobular lines superimposed on diffuse ground-glass opacities and should be recognized by emergency providers as a radiographic finding of progressive COVID-19.2-4

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