scholarly journals Cell-derived extracellular vesicles and membranes for tissue repair

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Yuan Ding ◽  
Yanjie Li ◽  
Zhongquan Sun ◽  
Xin Han ◽  
Yining Chen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Membrane ◽  
Tissue Repair ◽  
Extracellular Vesicle ◽  
Stem Cell Therapies ◽  
Differentiation Potential ◽  
Cell Therapies ◽  
Tissue Repair And Regeneration ◽  
Unmet Demand ◽  
Multipotent Differentiation

AbstractHumans have a limited postinjury regenerative ability. Therefore, cell-derived biomaterials have long been utilized for tissue repair. Cells with multipotent differentiation potential, such as stem cells, have been administered to patients for the treatment of various diseases. Researchers expected that these cells would mediate tissue repair and regeneration through their multipotency. However, increasing evidence has suggested that in most stem cell therapies, the paracrine effect but not cell differentiation or regeneration is the major driving force of tissue repair. Additionally, ethical and safety problems have limited the application of stem cell therapies. Therefore, nonliving cell-derived techniques such as extracellular vesicle (EV) therapy and cell membrane-based therapy to fulfil the unmet demand for tissue repair are important. Nonliving cell-derived biomaterials are safer and more controllable, and their efficacy is easier to enhance through bioengineering approaches. Here, we described the development and evolution from cell therapy to EV therapy and cell membrane-based therapy for tissue repair. Furthermore, the latest advances in nonliving cell-derived therapies empowered by advanced engineering techniques are emphatically reviewed, and their potential and challenges in the future are discussed. Graphical Abstract

Current Status of Stem Cell Therapies in Tissue Repair and Regeneration

2019 ◽  
Vol 14 (2) ◽  
pp. 117-126 ◽  
Author(s):  
Tapan Kumar Giri ◽  
Amit Alexander ◽  
Mukta Agrawal ◽  
Swarnalata Saraf ◽  
Shailendra Saraf ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Tissue Repair ◽  
Good Reason ◽  
Current Status ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Tissue Repair And Regeneration ◽  
Disciplinary Field ◽  
Repair Techniques

Tissue engineering is a multi-disciplinary field such as material science, life science, and bioengineering that are necessary to make artificial tissue or rejuvenate damaged tissue. Numerous tissue repair techniques and substitute now exist even though it has several shortcomings; these shortcomings give a good reason for the continuous research for more acceptable tissue-engineered substitutes. The search for and use of a suitable stem cell in tissue engineering is a promising concept. Stem cells have a distinctive capability to differentiate and self-renew that make more suitable for cell-based therapies in tissue repair and regeneration. This review article focuses on stem cell for tissue engineering and their methods of manufacture with their application in nerve, bone, skin, cartilage, bladder, cardiac, liver tissue repair and regeneration.

scholarly journals Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage: A Review

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Navneet Kumar Dubey ◽  
Viraj Krishna Mishra ◽  
Rajni Dubey ◽  
Shabbir Syed-Abdul ◽  
Joseph R. Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Growth Factors ◽  
Articular Cartilage ◽  
Current Status ◽  
Self Healing ◽  
Mechanical Stimuli ◽  
Stem Cell Therapies ◽  
Differentiation Potential ◽  
Cell Therapies

Knee osteoarthritis (OA) is a chronic degenerative disorder which could be distinguished by erosion of articular cartilage, pain, stiffness, and crepitus. Not only aging-associated alterations but also the metabolic factors such as hyperglycemia, dyslipidemia, and obesity affect articular tissues and may initiate or exacerbate the OA. The poor self-healing ability of articular cartilage due to limited regeneration in chondrocytes further adversely affects the osteoarthritic microenvironment. Traditional and current surgical treatment procedures for OA are limited and incapable to reverse the damage of articular cartilage. To overcome these limitations, cell-based therapies are currently being employed to repair and regenerate the structure and function of articular tissues. These therapies not only depend upon source and type of stem cells but also on environmental conditions, growth factors, and chemical and mechanical stimuli. Recently, the pluripotent and various multipotent mesenchymal stem cells have been employed for OA therapy, due to their differentiation potential towards chondrogenic lineage. Additionally, the stem cells have also been supplemented with growth factors to achieve higher healing response in osteoarthritic cartilage. In this review, we summarized the current status of stem cell therapies in OA pathophysiology and also highlighted the potential areas of further research needed in regenerative medicine.

scholarly journals Enabling stem cell therapies for tissue repair: Current and future challenges

2013 ◽  
Vol 31 (5) ◽  
pp. 744-751 ◽  
Author(s):  
Victor W. Wong ◽  
Michael Sorkin ◽  
Geoffrey C. Gurtner
Keyword(s):  
Stem Cell ◽  
Tissue Repair ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Future Challenges

Sternal bone marrow is a suitable autologous cell source for cardiac stem cell therapies

2014 ◽  
Vol 62 (S 01) ◽  
Author(s):  
M. Arar ◽  
A. Rotärmel ◽  
A.-K. Knoefel ◽  
H. Baraki ◽  
I. Kutschka ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Cardiac Stem Cell ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Autologous Cell ◽  
Cell Source

Endometrial Regeneration in Asherman's Syndrome: Clinical and Translational evidence of Stem Cell Therapies

2019 ◽  
Vol 14 (6) ◽  
pp. 454-459
Author(s):  
Xuejing Hou ◽  
Ying Liu ◽  
Isabelle Streuli ◽  
Patrick Dällenbach ◽  
Jean Dubuisson ◽  
...  
Keyword(s):  
Stem Cell ◽  
Molecular Mechanisms ◽  
Uterine Cavity ◽  
Stem Cell Therapies ◽  
Intrauterine Adhesions ◽  
Asherman’S Syndrome ◽  
Cell Therapies ◽  
Fibrotic Process ◽  
Physical Barriers

Asherman’s Syndrome or Intrauterine adhesions is an acquired uterine condition where fibrous scarring forms within the uterine cavity, resulting in reduced menstrual flow, pelvic pain and infertility. Until recently, the molecular mechanisms leading to the formation of fibrosis were poorly understood, and the treatment of Asherman’s syndrome has largely focused on hysteroscopic resection of adhesions, hormonal therapy, and physical barriers. Numerous studies have begun exploring the molecular mechanisms behind the fibrotic process underlying Asherman’s Syndrome as well as the role of stem cells in the regeneration of the endometrium as a treatment modality. The present review offers a summary of available stem cell-based regeneration studies, as well as highlighting current gaps in research.

Stem Cell Therapies

2016 ◽  
Vol 5 (2) ◽  
pp. 145-151
Author(s):  
Ana Muñoz ◽  
Víctor Galvez ◽  
María Camarasa
Keyword(s):  
Stem Cell ◽  
Stem Cell Therapies ◽  
Cell Therapies

Public Opinion and Expectations of Stem Cell Therapies in Orthopaedics*

2021 ◽  
Author(s):  
Richard N. Puzzitiello ◽  
Jeremy Dubin ◽  
Mariano E. Menendez ◽  
Michael A. Moverman ◽  
Nicholas R. Pagani ◽  
...  
Keyword(s):  
Stem Cell ◽  
Public Opinion ◽  
Stem Cell Therapies ◽  
Cell Therapies
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