Evidence-based practices (EBPs) for children and adolescents have undergone significant transformation in the past decade. This chapter synthesizes the major paradigm shifts in policy, research, and practice. The policy paradigm shifts include healthcare infrastructure changes that reshape the mental health delivery system, accountability of mental health care that is driven by quality indicators, and new financing policies under the Affordable Care Act. The research paradigm shifts include development of innovative dissemination and implementation (D&I) models to improve the spread and uptake of EBPs, and the use of optimal D&I designs and measures to empirically study system-level changes. The practice paradigm shifts include primary care integration, large-scale training, technological advances, and task shifting in EBPs. Moving from laboratory testing and knowledge translation of EBPs in the past decade, the current and future direction of EBPs necessitates concerted responses to these paradigm shifts among policymakers, researchers, practitioners, consumers, and families.