scholarly journals Targeting human epidermal growth factor receptor 2 enhances radiosensitivity and reduces the metastatic potential of Lewis lung carcinoma cells

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Yun Tien ◽  
Chiao-Ling Tsai ◽  
Wei-Hsien Hou ◽  
Yun Chiang ◽  
Feng-Ming Hsu ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Lewis Lung Carcinoma ◽  
Growth Factor Receptor ◽  
Metastatic Potential ◽  
Carcinoma Cells ◽  
Lewis Lung ◽  
Lung Carcinoma Cells ◽  
Epidermal Growth ◽  
Lewis Lung Carcinoma Cells

Differential expression of a tropomyosin isoform in low- and high-metastatic Lewis lung carcinoma cells

1988 ◽  
Vol 8 (9) ◽  
pp. 3934-3937
Author(s):  
K Takenaga ◽  
Y Nakamura ◽  
S Sakiyama
Keyword(s):  
Dimethyl Sulfoxide ◽  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Metastatic Potential ◽  
Carcinoma Cells ◽  
Two Dimensional ◽  
Lewis Lung ◽  
Metastatic Phenotype ◽  
Lung Carcinoma Cells ◽  
Lewis Lung Carcinoma Cells

Two-dimensional electrophoretograms of newly synthesized polypeptides from low-metastatic (P29) and high-metastatic (D6) Lewis lung carcinoma cells were compared. The results showed that the synthesis of tropomyosin 2 (TM2) was significantly less in D6 cells than in P29 cells. Furthermore, suppression of TM2 synthesis was induced in P29 cells during incubation in medium containing dimethyl sulfoxide or butyric acid, which induced the metastatic phenotype of P29 cells. These results suggest that the suppression of TM2 synthesis is linked to the metastatic potential of Lewis lung carcinoma cells.

Midkine, a heparin-binding growth factor, produced by the host enhances metastasis of Lewis lung carcinoma cells

2006 ◽  
Vol 233 (1) ◽  
pp. 16-20 ◽  
Author(s):  
Ragaa H.M. Salama ◽  
Hisako Muramatsu ◽  
Peng Zou ◽  
Minoru Okayama ◽  
Takashi Muramatsu
Keyword(s):  
Growth Factor ◽  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Carcinoma Cells ◽  
Heparin Binding ◽  
Lewis Lung ◽  
Lung Carcinoma Cells ◽  
Lewis Lung Carcinoma Cells

scholarly journals Differential expression of a tropomyosin isoform in low- and high-metastatic Lewis lung carcinoma cells.

1988 ◽  
Vol 8 (9) ◽  
pp. 3934-3937 ◽  
Author(s):  
K Takenaga ◽  
Y Nakamura ◽  
S Sakiyama
Keyword(s):  
Dimethyl Sulfoxide ◽  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Metastatic Potential ◽  
Carcinoma Cells ◽  
Two Dimensional ◽  
Lewis Lung ◽  
Metastatic Phenotype ◽  
Lung Carcinoma Cells ◽  
Lewis Lung Carcinoma Cells

Two-dimensional electrophoretograms of newly synthesized polypeptides from low-metastatic (P29) and high-metastatic (D6) Lewis lung carcinoma cells were compared. The results showed that the synthesis of tropomyosin 2 (TM2) was significantly less in D6 cells than in P29 cells. Furthermore, suppression of TM2 synthesis was induced in P29 cells during incubation in medium containing dimethyl sulfoxide or butyric acid, which induced the metastatic phenotype of P29 cells. These results suggest that the suppression of TM2 synthesis is linked to the metastatic potential of Lewis lung carcinoma cells.

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