scholarly journals Maternal drug use and the risk of anorectal malformations: systematic review and meta-analysis

2018 ◽  
Vol 13 (1) ◽  
Author(s):  
Nadine Zwink ◽  
Ekkehart Jenetzky
Keyword(s):  
Systematic Review ◽  
Drug Use ◽  
Meta Analysis ◽  
Anorectal Malformations ◽  
Maternal Drug Use

scholarly journals Pharmacological interventions for drug-using offenders: an update to a systematic review and meta-analysis

2021 ◽  
Author(s):  
J. M. Glanville ◽  
A. E. Perry ◽  
M. Martyn-St James ◽  
C. Hewitt ◽  
S. Swami ◽  
...  
Keyword(s):  
Systematic Review ◽  
Drug Use ◽  
Meta Analysis ◽  
Treatment Options ◽  
Criminal Activity ◽  
Cochrane Collaboration ◽  
Pharmacological Interventions ◽  
Serious Adverse Events ◽  
Male Adult ◽  
The Impact

Abstract This updated systematic review assesses the effects of pharmacological interventions for drug-using offenders. Methods Systematic review protocols and conventions of the Cochrane Collaboration were followed to identify eligible studies. Studies were pooled in a meta-analysis to assess the impact of pharmacological interventions on drug use and criminal activity. An economic appraisal was conducted. Results The search strategies identified 22 studies containing 4372 participants. Meta-analyses revealed a small statistically significant mean difference favouring pharmacological interventions relative to psychological interventions in reducing drug use and criminal activity. When comparing the drugs to one another there were no significant differences between those included (methadone versus buprenorphine, naltrexone and cyclazocine). Conclusion Overall, the findings of this review suggest that methadone and naltrexone may have some impact on reducing drug use and reincarceration. Individual pharmacological drugs had differing (generally non-significant) effects. One study identified serious adverse events. Three studies reported cost and consequences information sufficient to conduct a full economic analysis but this was not comprehensive enough to be able to make judgements across all treatment options. Full economic analyses should be encouraged. The study findings were limited mainly to male adult offenders.

scholarly journals Short and long-term quality of life outcomes in children after surgery for Hirschsprung Disease or Anorectal Malformations: A systematic review and meta-analysis

2020 ◽  
Author(s):  
Irina Oltean ◽  
Emily Beveridge ◽  
Lamia Hayawi ◽  
Vid Bijelic ◽  
Ahmed Nasr
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Psychosocial Functioning ◽  
Meta Analysis ◽  
Hirschsprung Disease ◽  
Cochrane Collaboration ◽  
Anorectal Malformations ◽  
Case Control Studies ◽  
Social And Emotional

There is paucity of evidence examining quality of life in children with HD and ARM prioritizing dimensions other than physical functioning, such as psychosocial functioning in a precise manner. As such, we have developed a systematic review protocol to narratively and quantitatively summarize the physical and psychosocial functioning of children affected by HD and ARM in hopes of addressing this limitation. The following databases were searched on Nov 5, 2019: MEDLINE including Epub Ahead of Print, In-Process & Other Non-Indexed Citations (1946 to October 25, 2019) and Embase (1947 to 2019 October 25) and the CENTRAL Trials Registry of the Cochrane Collaboration (September 2019 Issue) using the Ovid interface. Searches were limited to English, to journal articles, and articles published since 2006. This review will identify retrospective and prospective cohort studies, case-control studies, case studies with greater than 5 participants, and randomized-control trials where the quality of life (i.e., physical and/or social functioning) of children aged 0-18 years with either anorectal malformations or Hirschprung’s disease is reported by children or parent proxies. Understanding the quality of life of children affected by HD and ARM after surgery will help clinical practitioners, specifically surgeons, create tailored and comprehensive protocols for managing these diseases while recognising the physical, social, and emotional toll they can inflict on children.

scholarly journals Drug Use and Postoperative Mortality Following Valve Surgery for Infective Endocarditis: A Systematic Review and Meta-analysis

2018 ◽  
Vol 69 (7) ◽  
pp. 1120-1129 ◽  
Author(s):  
Ryan Hall ◽  
Michael Shaughnessy ◽  
Griffin Boll ◽  
Kenneth Warner ◽  
Helen W Boucher ◽  
...  
Keyword(s):  
Systematic Review ◽  
Infective Endocarditis ◽  
Drug Use ◽  
Injection Drug Use ◽  
Systematic Reviews ◽  
Meta Analysis ◽  
Postoperative Mortality ◽  
Valve Surgery ◽  
Injection Drug ◽  
Significant Difference

AbstractBackgroundInfective endocarditis (IE) often requires surgical intervention. An increasingly common cause of IE is injection drug use (IDU-IE). There is conflicting evidence on whether postoperative mortality differs between people with IDU-IE and people with IE from etiologies other than injection drug use (non–IDU-IE). In this manuscript, we compare short-term postoperative mortality in IDU-IE vs non–IDU-IE through systematic review and meta-analysis.MethodsThe review was conducted according to the Cochrane Handbook for Systematic Reviews of Interventions and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Publication databases were queried for key terms included in articles up to September 2017. Randomized controlled trials, prospective cohorts, or retrospective cohorts that reported on 30-day mortality or in-hospital/operative mortality following valve surgery and that compared outcomes between IDU-IE and non–IDU-IE were included.ResultsThirteen studies with 1593 patients (n = 341 [21.4%] IDU-IE) were included in the meta-analysis. IDU-IE patients more frequently had tricuspid valve infection, Staphylococcus infection, and heart failure before surgery. Meta-analysis revealed no statistically significant difference in 30-day postsurgical mortality or in-hospital mortality between the 2 groups.ConclusionsDespite differing preoperative clinical characteristics, early postoperative mortality does not differ between IDU-IE and non–IDU-IE patients who undergo valve surgery. Future research on long-term outcomes following valve replacement is needed to identify opportunities for improved healthcare delivery with IDU-IE.

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