scholarly journals Tunicamycin specifically aggravates ER stress and overcomes chemoresistance in multidrug-resistant gastric cancer cells by inhibiting N-glycosylation

2018 ◽  
Vol 37 (1) ◽  
Author(s):  
Jian Wu ◽  
Sheng Chen ◽  
Hao Liu ◽  
Zhe Zhang ◽  
Zhen Ni ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Er Stress ◽  
Cancer Cells ◽  
Multidrug Resistant ◽  
Gastric Cancer Cells

Abstract 3512: Cyclopamine enhances TRAIL-induced apoptosis by induction of DR5 via ER stress in gastric cancer cells

2016 ◽  
Author(s):  
Yoo Jin Na ◽  
Dae-Hee Lee ◽  
Jung Lim Kim ◽  
Bo Ram Kim ◽  
Seong Hye Park ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Er Stress ◽  
Cancer Cells ◽  
Gastric Cancer Cells ◽  
Induced Apoptosis

scholarly journals MGr1-Ag is associated with multidrug-resistant phenotype of gastric cancer cells

2002 ◽  
Vol 5 (3) ◽  
pp. 154-159 ◽  
Author(s):  
Yongquan Shi ◽  
Ying Han ◽  
Xin Wang ◽  
Yanqiu Zhao ◽  
Xiaoxuan Ning ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Multidrug Resistant ◽  
Gastric Cancer Cells ◽  
Resistant Phenotype

scholarly journals Adenovirus-mediated IL-24 expression enhances the chemosensitivity of multidrug-resistant gastric cancer cells to cisplatin

2013 ◽  
Vol 30 (5) ◽  
pp. 2288-2296 ◽  
Author(s):  
ZONGLEI MAO ◽  
GUOCHUN BIAN ◽  
WEIHUA SHENG ◽  
SONGBIN HE ◽  
JICHENG YANG ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Multidrug Resistant ◽  
Gastric Cancer Cells

β-Elemene inhibits the metastasis of multidrug-resistant gastric cancer cells through miR-1323/Cbl-b/EGFR pathway

Phytomedicine ◽  
2020 ◽  
Vol 69 ◽  
pp. 153184 ◽  
Author(s):  
Mingming Deng ◽  
Bofang Liu ◽  
Huicong Song ◽  
Ruoxi Yu ◽  
Dan Zou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Multidrug Resistant ◽  
Gastric Cancer Cells

scholarly journals Overexpression of ZNRD1 Promotes Multidrug-Resistant Phenotype of Gastric Cancer Cells Through Upregulation of P-Glycoprotein

2004 ◽  
Vol 3 (4) ◽  
pp. 377-381 ◽  
Author(s):  
Yongquan Shi ◽  
Yumei Zhang ◽  
Yanqiu Zhao ◽  
Liu Hong ◽  
Na Liu Hizohang Jin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Multidrug Resistant ◽  
Gastric Cancer Cells ◽  
Resistant Phenotype ◽  
P Glycoprotein

scholarly journals Cinnamaldehyde induces autophagy-mediated cell death through ER stress and epigenetic modification in gastric cancer cells

2021 ◽  
Author(s):  
Tae Woo Kim
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Er Stress ◽  
Cancer Cells ◽  
Molecular Mechanisms ◽  
Epigenetic Modification ◽  
Autophagic Cell Death ◽  
Beclin 1 ◽  
Gastric Cancer Cells ◽  
Autophagy Inhibition

AbstractPrevious reports suggested that cinnamaldehyde (CA), the bioactive ingredient in Cinnamomum cassia, can suppress tumor growth, migratory, and invasive abilities. However, the role and molecular mechanisms of CA in GC are not completely understood. In the present study, we found that CA-induced ER stress and cell death via the PERK–CHOP axis and Ca2+ release in GC cells. Inhibition of ER stress using specific–siRNA blocked CA-induced cell death. Interestingly, CA treatment resulted in autophagic cell death by inducing Beclin-1, ATG5, and LC3B expression and by inhibiting p62 expression whereas autophagy inhibition suppressed CA-induced cell death. We showed that CA induces the inhibition of G9a and the activation of LC3B. Moreover, CA inhibited G9a binding on Beclin-1 and LC3B promoter. Overall, these results suggested that CA regulates the PERK–CHOP signaling, and G9a inhibition activates autophagic cell death via ER stress in GC cells.

scholarly journals Wogonoside promotes apoptosis and ER stress in human gastric cancer cells by regulating the IRE1α pathway

2021 ◽  
Vol 21 (4) ◽  
Author(s):  
Qian Gu ◽  
Canhong Zhu ◽  
Xi Wu ◽  
Lianghuan Peng ◽  
Genya Huang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Er Stress ◽  
Cancer Cells ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells
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