Transmuscular quadratus lumborum block versus thoracic paravertebral block for acute pain and quality of recovery after laparoscopic renal surgery: study protocol for a randomized controlled trial

Bilateral quadratus lumborum blockade (QLB) using ultrasound guidance has been introduced as an abdominal truncal block to improve postoperative analgesia and quality of recovery (QoR) after abdominal surgery, but efficacy remains controversial. The primary aim of this study was to evaluate the efficacy of posterior QLB on the postoperative QoR, and secondarily to evaluate postoperative pain after gynaecological laparoscopic surgery (LS). This study was a single-centre randomized controlled trial. QLB group patients underwent bilateral posterior quadratus lumborum injections with 25–30 mL of 0.25% levobupivacaine after induction of general anaesthesia; the control group underwent no block. Both groups were administered fentanyl-based intravenous patient-controlled analgesia postoperatively. The postoperative QoR was measured using the Quality of Recovery 40 (QoR-40) questionnaire score; postoperative pain was evaluated using the visual analogue scale (VAS) and the cumulative postoperative fentanyl dose. Thirty-one and 29 patients were randomised to the QLB and control groups, respectively. The intraoperative remifentanil dosage was significantly less in the QLB group. The median (interquartile range) for the QoR-40 score was not different between the groups: 154 (133–168) in the QLB group and 158 (144–172) in the control group. There were no statistically significant differences in secondary outcome variables. Single-shot QLB did not improve the QoR or postoperative pain in patients managed by multimodal analgesia after gynaecological LS.

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Preoperative Duloxetine to improve acute pain and quality of recovery in patients undergoing modified radical mastectomy: A dose-ranging randomized controlled trial

Journal of Clinical Anesthesia ◽

10.1016/j.jclinane.2020.110007 ◽

2020 ◽

Vol 67 ◽

pp. 110007 ◽

Cited By ~ 1

Author(s):

Diab Fuad Hetta ◽

Nourhan Alaa Elgalaly ◽

Helal F. Hetta ◽

Montaser A. Fattah Mohammad

Keyword(s):

Randomized Controlled Trial ◽

Acute Pain ◽

Controlled Trial ◽

Radical Mastectomy ◽

Modified Radical Mastectomy ◽

Quality Of Recovery ◽

Randomized Controlled ◽

Dose Ranging

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Randomized trial of acupressure to improve patient satisfaction and quality of recovery in hospitalized patients: study protocol for a randomized controlled trial

Trials ◽

10.1186/s13063-017-1839-1 ◽

2017 ◽

Vol 18 (1) ◽

Cited By ~ 4

Author(s):

Eric Noll ◽

Shivam Shodhan ◽

Maria Cecilia Madariaga ◽

Christopher R. Page ◽

Diane Santangelo ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Patient Satisfaction ◽

Randomized Trial ◽

Study Protocol ◽

Controlled Trial ◽

Improve Patient Satisfaction ◽

Quality Of Recovery ◽

Randomized Controlled ◽

Improve Patient

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Efficacy of a Web-Enabled, School-Based, Preventative Intervention to Reduce Bullying and Improve Mental Health in Children and Adolescents: Study Protocol for a Cluster Randomized Controlled Trial

Frontiers in Pediatrics ◽

10.3389/fped.2021.628984 ◽

2021 ◽

Vol 9 ◽

Author(s):

Covadonga M. Díaz-Caneja ◽

Javier Martín-Babarro ◽

Renzo Abregú-Crespo ◽

Miguel Á. Huete-Diego ◽

Marta Giménez-Dasí ◽

...

Keyword(s):

Quality Of Life ◽

Mental Health ◽

Randomized Controlled Trial ◽

Study Protocol ◽

Controlled Trial ◽

Bullying Victimization ◽

Randomized Controlled ◽

School Based ◽

Cluster Randomized

Introduction: Bullying is a major preventable risk factor for mental disorders. Available evidence suggests school-based interventions reduce bullying prevalence rates. This study aims to test the efficacy of a web-enabled, school-based, multicomponent anti-bullying intervention to prevent school bullying and to assess its effects on mental health and quality of life.Methods and analysis: Cluster randomized controlled trial conducted in 20 publicly funded primary and secondary schools in Madrid, Spain. Schools are randomly allocated to either the intervention arm (n = 10) or conventional practices arm (n = 10). The web-enabled intervention (LINKlusive) lasts ~12 weeks and consists of three main components: (i) an online training program for teachers and parents, (ii) a web-guided educational program for students, focusing on promoting respect for diversity, empathy, and social skill development, and (iii) a web-guided, teacher-delivered, targeted intervention program for bullying situations identified based on peer-support strategies and individual intervention for those involved (i.e., bullying victims and perpetrators). The primary objective is to compare differences between peer-reported bullying victimization in the intervention and control arms at the end of the intervention. Secondary outcome measures are additional measures of bullying victimization and perpetration, mental health symptoms, self-esteem, and quality of life. A follow-up assessment is conducted 1 year after the end of the intervention. Treatment effects will be tested using multilevel mixed models, adjusting for school-, classroom-, and student-related covariates. Considering the increased bullying rates in children with special educational needs, a specific subgroup analysis will test the efficacy of the intervention on bullying prevalence, mental health, and quality of life in this particularly vulnerable population.Ethics and Dissemination: The Deontology Commission of the School of Psychology, Universidad Complutense in Madrid, Spain reviewed the study protocol and granted ethical approval on 21st January 2019. The results of the trial will be disseminated in relevant peer-reviewed journals and at conferences in the field.Trial Registration Number: ISRCTN15719015.

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