scholarly journals Comparison of the clinical and cost effectiveness of two management strategies (rehabilitation versus surgical reconstruction) for non-acute anterior cruciate ligament (ACL) injury: study protocol for the ACL SNNAP randomised controlled trial

Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Loretta Davies ◽  
Jonathan Cook ◽  
Jose Leal ◽  
Carlos Morgado Areia ◽  
Beverly Shirkey ◽  
...  
Author(s):  
Daphne I Ling ◽  
Theresa A Chiaia ◽  
Polly deMille ◽  
Robert G Marx

ObjectivesThe psychological and physical recovery after anterior cruciate ligament (ACL) reconstruction (ACLR) may or may not occur in parallel. A common scenario is the uninformed athlete who lacks awareness of physical deficiencies and returns to sport prematurely. There is increasing evidence that most patients do not meet return to play criteria at 6 months and physical deficits may still persist 1 year after surgery. We hypothesise that a Quality of Movement Assessment for Return to Sport (QMA-RTS) testing programme may have a negative impact on athletes’ perception of psychological readiness to return.MethodsA total of 30 athletes who had ACLR and underwent the QMA-RTS 4–10 months after ACLR were recruited. They were randomised to one of two groups that both completed a baseline ACL Return to Sport after Injury (ACL-RSI) scale before their QMA-RTS appointment. In the intervention group, participants completed a second ACL-RSI after the QMA-RTS. In the control group, participants completed their second survey before the session. The mean difference in scores between the two groups was compared using an independent samples t-test.ResultsThe groups were balanced for sex (9/15 female), mean age (16 years) and average time since surgery (6 months). The baseline ACL-RSI scores were not statistically different between groups (4.6 (95% CI −10.6 to 19.8), p=0.54). In the controls, there was an increase in scores (+4.4) between the first and second surveys, while there was a decrease in the intervention group (−3.4). This difference between groups was not statistically significant (7.8 (95% CI −1.7 to 17.3), p=0.10).ConclusionsThe QMA-RTS programme did not significantly reduce patients’ mean scores on the ACL-RSI compared with controls. The limited effect on psychological responses may be due to the athletes’ self-awareness of their physical deficits at 6 months after ACLR.Level of evidenceLevel II, randomised controlled trial.


2021 ◽  
Vol 10 (18) ◽  
pp. 4051
Author(s):  
Shin Fukusato ◽  
Masashi Nagao ◽  
Kei Fujihara ◽  
Taiju Yoneda ◽  
Kiyotaka Arai ◽  
...  

Anterior cruciate ligament (ACL) rupture is a common knee injury for athletes. Although surgical reconstruction is recommended for the treatment of ACL ruptures, 100% functional recovery is unlikely. Therefore, the discovery of risk factors for ACL ruptures may prevent injury. Several studies have reported an association between polymorphisms of the collagen XII gene COL12A1 and ACL rupture. Collagen XII is highly expressed in tendons and ligaments and regulates tissue structure and mechanical property. Therefore, we hypothesized that collagen XII deficiency may cause ACL injury. To elucidate the influence of collagen XII deficiency on ACL, we analyzed a mouse model deficient for Col12a1. Four- to 19-week-old male Col12a1-/- and wild-type control mice were used for gait analysis; histological and immunofluorescent analysis of collagen XII, and real-time RT-PCR evaluation of Col12a1 mRNA expression. The Col12a1-/- mice showed an abnormal gait with an approximately 2.7-fold increase in step angle, suggesting altered step alignment. Col12a1-/- mice displayed 20–60% ACL discontinuities, but 0% discontinuity in the posterior cruciate ligament. No discontinuities in knee ligaments were found in wild-type mice. Collagen XII mRNA expression in the ACL tended to decrease with aging. Our study demonstrates for the first time that collagen XII deficiency increases the risk of ACL injury.


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