scholarly journals Differential response of serum amyloid A to different therapies in early rheumatoid arthritis and its potential value as a disease activity biomarker

2016 ◽  
Vol 18 (1) ◽  
Author(s):  
Yong Gil Hwang ◽  
Goundappa K. Balasubramani ◽  
Ilinca D. Metes ◽  
Marc C. Levesque ◽  
S. Louis Bridges ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Early Rheumatoid Arthritis ◽  
Serum Amyloid A ◽  
Differential Response ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Potential Value

scholarly journals Serum Amyloid A as a Marker of Persistent Inflammation and an Indicator of Cardiovascular and Renal Involvement in Patients with Rheumatoid Arthritis

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Bożena Targońska-Stępniak ◽  
Maria Majdan
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Serum Amyloid A ◽  
Renal Involvement ◽  
Serum Amyloid ◽  
Laboratory Assessment ◽  
Amyloid A ◽  
Persistent Inflammation ◽  
Systemic Inflammatory Disease ◽  
The Mean

Objectives. Rheumatoid arthritis (RA) is a systemic, inflammatory disease. Serum amyloid A (SAA) is an acute-phase protein, involved in pathogenesis of atherosclerosis. The aim of the study was to assess serum concentration of SAA in RA patients, with reference to other inflammatory parameters and markers of extra-articular involvement.Methods. The study population consisted of 140 RA patients, low/moderate disease activity (L/MDA) in 98 (70%) patients and high disease activity (HDA) in 42 (30%). Comprehensive clinical and laboratory assessment was performed with evaluation of electrocardiogram and carotid intima-media thickness.Results. The mean SAA concentration [327.0 (263.4) mg/L] was increased highly above the normal value, even in patients with L/MDA. Simultaneously, SAA was significantly higher in patients with HDA versus L/MDA. The mean SAA concentration was significantly higher in patients treated with glucocorticoids, was inversely associated with QTc duration, and was markedly higher in patients with atherosclerotic plaques, emphasizing increased CV risk. SAA was significantly higher in patients with increased cystatin-C level.Conclusions. In RA patients, high serum SAA concentration was strongly associated with activity of the disease and risk of CV and renal involvement. Recurrent assessment of SAA may facilitate searching patients with persistent inflammation and risk of extra-articular complications.

An involvement of SR-B1 mediated p38 MAPK signaling pathway in serum amyloid A-induced angiogenesis in rheumatoid arthritis

2015 ◽  
Vol 66 (2) ◽  
pp. 340-345 ◽  
Author(s):  
Chengcheng Hong ◽  
Chen Shen ◽  
Hongmei Ding ◽  
Shanshan Huang ◽  
Yun Mu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Signaling Pathway ◽  
P38 Mapk ◽  
Serum Amyloid A ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Serum Amyloid ◽  
Amyloid A

Serum amyloid A is a useful marker to evaluate the disease activity of Takayasu’s arteritis

2009 ◽  
Vol 30 (4) ◽  
pp. 561-563 ◽  
Author(s):  
Tomohiro Koga ◽  
Yuichiro Nishino ◽  
Junya Makiyama ◽  
Takeshi Hayashida ◽  
Taichiro Miyashita ◽  
...  
Keyword(s):  
Disease Activity ◽  
Serum Amyloid A ◽  
Takayasu’S Arteritis ◽  
Serum Amyloid ◽  
Takayasu's Arteritis ◽  
Amyloid A

Serum amyloid A as a marker of disease activity and treatment response in Takayasu arteritis

2017 ◽  
Vol 37 (10) ◽  
pp. 1643-1649 ◽  
Author(s):  
Aswin M. Nair ◽  
Ruchika Goel ◽  
M. Hindhumati ◽  
K. Jayakanthan ◽  
J. Visalakshi ◽  
...  
Keyword(s):  
Disease Activity ◽  
Treatment Response ◽  
Takayasu Arteritis ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Amyloid A

Synovial Fluid from Rheumatoid Arthritis Patients Contains Sufficient Levels of IL-1β and IL-6 to Promote Production of Serum Amyloid A By HEP3B Cells

Cytokine ◽  
1995 ◽  
Vol 7 (2) ◽  
pp. 209-219 ◽  
Author(s):  
Patricia A. McNiff ◽  
Caroline Stewart ◽  
James Sullivan ◽  
Henry J. Showell ◽  
Christopher A. Gabel
Keyword(s):  
Rheumatoid Arthritis ◽  
Synovial Fluid ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Hep3b Cells
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