scholarly journals Comparison of reversal of rat pulmonary fibrosis of nintedanib, pirfenidone, and human umbilical mesenchymal stem cells from Wharton’s jelly

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Kuo-An Chu ◽  
Chang-Ching Yeh ◽  
Fu-Hsien Kuo ◽  
Wen-Ren Lin ◽  
Chien-Wei Hsu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Pulmonary Fibrosis ◽  
Oxygen Saturation ◽  
Cell Number ◽  
Blood Oxygen ◽  
Collagen Deposition ◽  
Alveolar Space ◽  
Blood Oxygen Saturation ◽  
Umbilical Mesenchymal Stem Cells

Abstract Background The present study compared the effects of antifibrotic medications, pirfenidone, and nintedanib, with transplantation of human umbilical mesenchymal stem cells (HUMSCs) in restoring rat pulmonary fibrosis (PF). Methods A stable animal model was established via an intratracheal injection of 5 mg bleomycin (BLM). One single transplantation of 2.5× 107 HUMSCs or initiation of daily oral nintedanib/pirfenidone administration was performed on day 21 following BLM damage. Results Pulmonary function examination revealed that BLM rats exhibited a significant decrease in blood oxygen saturation and an increase in respiratory rates. While no significant improvements were found in BLM rats receiving nintedanib or pirfenidone, those who transplanted with HUMSCs showed a statistical amelioration in blood oxygen saturation and significant alleviation in respiratory rates. Quantification results revealed that a significant reduction in alveolar space and marked increases in substantial cell infiltration and collagen deposition in the left lungs of BLM rats. No significant alteration was observed in BLM rats administered nintedanib or pirfenidone. However, BLM rats transplanted with HUMSCs had a significant recovery in alveolar space and noticeable decreases in cell infiltration and collagen deposition. The inflammatory cell numbers in the bronchoalveolar lavage was increased in the BLM group. While the rats treated with nintedanib or pirfenidone had a lower cell number than the BLM group, a higher cell number was found as compared with the Normal group. In rats transplanted with HUMSCs, the cell number did not differ from the Normal group. Conclusions Transplantation of HUMSCs could effectively treat PF as opposed to the administration of anti-fibrotic drugs with nintedanib or pirfenidone with a significant better result in lung volume, pathological changes, lung function, and blood oxygen saturation.

scholarly journals Comparison of Reversal of Rat Pulmonary Fibrosis of Nintedanib, Pirfenidone and Human Umbilical Mesenchymal Stem Cells from Wharton’s Jelly

2020 ◽  
Author(s):  
Kuo-An Chu ◽  
Chang-Ching Yeh ◽  
Fu-Hsien Kuo ◽  
Wen-Ren Lin ◽  
Chien-Wei Hsu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Pulmonary Fibrosis ◽  
Oxygen Saturation ◽  
Cell Number ◽  
Blood Oxygen ◽  
Collagen Deposition ◽  
Alveolar Space ◽  
Blood Oxygen Saturation ◽  
Umbilical Mesenchymal Stem Cells

Abstract Background:The present study compared the effects of antifibrotic medications, pirfenidone and nintedanib, with transplantation of human umbilical mesenchymal stem cells (HUMSCs) in restoring rat pulmonary fibrosis (PF).Methods:A stable animal model was established via an intratracheal injection of 5 mg bleomycin (BLM). One single transplantation of 2.5 × 107 HUMSCs or initiation of daily oral nintedanib/pirfenidone administration was performed on Day 21 following BLM damage.Results:Pulmonary function examination revealed that BLM rats exhibited a significant decrease in blood oxygen saturation and an increase in respiratory rates. While no significant improvements were found in BLM rats receiving nintedanib or pirfenidone, those who transplanted with HUMSCs showed statistical amelioration in blood oxygen saturation and significant alleviation in respiratory rates. Quantification results revealed that a significant reduction in alveolar space and marked increases in substantial cell infiltration and collagen deposition in the left lungs of BLM rats. No significant alteration was observed in BLM rats administered nintedanib or pirfenidone. However, BLM rats transplanted with HUMSCs had a significant recovery in alveolar space and noticeable decreases in cell infiltration and collagen deposition. The inflammatory cell numbers in the bronchoalveolar lavage was increased in the BLM group. While the rats treated with nintedanib or pirfenidone had a lower cell number than the BLM group, a higher cell number was found as compared with the Normal group. In rats transplanted with HUMSCs, the cell number did not differ from the Normal group.Conclusions:Transplantation of HUMSCs could effectively treat PF as opposed to the administration of anti-fibrotic drugs with nintedanib or pirfenidone with significant better result in lung volume, pathological changes, lung function and blood oxygen saturation.

scholarly journals Comparison of Reversal of Rat Pulmonary Fibrosis of Nintedanib, Pirfenidone and Human Umbilical Mesenchymal Stem Cells from Wharton’s Jelly

2020 ◽  
Author(s):  
Kuo-An Chu ◽  
Chang-Ching Yeh ◽  
Fu-Hsien Kuo ◽  
Wen-Ren Lin ◽  
Chien-Wei Hsu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Pulmonary Fibrosis ◽  
Oxygen Saturation ◽  
Cell Number ◽  
Blood Oxygen ◽  
Collagen Deposition ◽  
Alveolar Space ◽  
Blood Oxygen Saturation ◽  
Umbilical Mesenchymal Stem Cells

Abstract Background:The present study compared the effects of antifibrotic medications, Pirfenidone and Nintedanib, with transplantation of human umbilical mesenchymal stem cells (HUMSCs) in restoring rat pulmonary fibrosis (PF).Methods:A stable animal model was established via an intratracheal injection of 5 mg bleomycin (BLM). One single transplantation of 2.5 107 HUMSCs or initiation of daily oral Nintedanib/Pirfenidone administration was performed on Day 21 following BLM damage.Results:Pulmonary function examination revealed that BLM rats exhibited a significant decrease in blood oxygen saturation and an increase in respiratory rates. While no significant improvements were found in BLM rats receiving Nintedanib or Pirfenidone, those who transplanted with HUMSCs showed statistical amelioration in blood oxygen saturation and significant alleviation in respiratory rates. Quantification results revealed that a significant reduction in alveolar space and marked increases in substantial cell infiltration and collagen deposition in the left lungs of BLM rats. No significant alteration was observed in BLM rats administered Nintedanib or Pirfenidone. However, BLM rats transplanted with HUMSCs had a significant recovery in alveolar space and noticeable decreases in cell infiltration and collagen deposition. The inflammatory cell numbers in the bronchoalveolar lavage was increased in the BLM group. While the rats treated with Nintedanib or Pirfenidone had a lower cell number than the BLM group, a higher cell number was found as compared with the Normal group. In rats transplanted with HUMSCs, the cell number did not differ from the Normal group.Conclusions:Transplantation of HUMSCs could effectively treat PF as opposed to the administration of anti-fibrotic drugs with Nintedanib or Pirfenidone with significant better result in lung volume, pathological changes, lung function and blood oxygen saturation.

scholarly journals Reversal of bleomycin-induced rat pulmonary fibrosis by a xenograft of human umbilical mesenchymal stem cells from Wharton's jelly

Theranostics ◽  
2019 ◽  
Vol 9 (22) ◽  
pp. 6646-6664 ◽  
Author(s):  
Kuo-An Chu ◽  
Shih-Yao Wang ◽  
Chang-Ching Yeh ◽  
Tz-Win Fu ◽  
Yu-Yi Fu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Pulmonary Fibrosis ◽  
Wharton’S Jelly ◽  
Wharton's Jelly ◽  
Umbilical Mesenchymal Stem Cells

scholarly journals PSIX-9 Impacts of bunk management on feedlot performance, carcass characteristics, hydrogen sulfide concentration and blood oxygen saturation in steers fed 25 or 50% modified distillers grains plus solubles

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 422-422
Author(s):  
Rebecca L Moore ◽  
Cierrah J Kassetas ◽  
Leslie A LeKatz ◽  
Bryan W Neville
Keyword(s):  
Hydrogen Sulfide ◽  
Oxygen Saturation ◽  
Management Strategy ◽  
Distillers Grains ◽  
Feed Ratio ◽  
Sulfide Concentration ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Feedlot Performance ◽  
Arterial Blood

Abstract One hundred and twenty-six yearling angus steers (initial body weight 445.87 ± 7.13 kg) were utilized in a 2 x 2 factorial design to evaluate the impacts of bunk management and modified distillers grains plus solubles (mDGS) inclusion on feedlot performance, hydrogen sulfide concentrations and blood oxygen saturation. Treatments included bunk management strategy either control bunk management (CON; clean bunks at the time of next day’s feeding) or long bunk management (LONG; feed remaining at time of next day’s feeding), and two inclusion rates of mDGS either 25% or 50% (DM Basis). On d 0, 7, 14, 21, 28 and 35 rumen gas samples were collected via rumenocentesis, and arterial blood samples were collected on two steers from each pen. No differences (P ≥ 0.09) were observed for dry matter intake, average daily gain and gain-to-feed ratio for bunk management or mDGS inclusion. Hot carcass weight, ribeye area, marbling score and quality grade were not affected (P ≥ 0.48) by either bunk management or mDGS inclusion. Back fat was greater (P = 0.04) for CON steers compared to LONG (1.30 vs 1.12 ± 0.05cm, respectively), but was not affected (P = 0.59) by mDGS inclusion. Steers on CON had greater (P = 0.03) yield grades compared to LONG (3.21 vs 2.96 ± 0.11, respectively). Bunk management strategy did not impact hydrogen sulfide concentrations or blood oxygen saturation (P = 0.82). Hydrogen sulfide concentrations increased (P < 0.001) with increasing mDGS inclusion. Blood oxygen saturation was influenced by day of sampling (P = 0.01). Blood oxygen saturation was not affected (P = 0.07) by mDGS inclusion. The fact that ruminal hydrogen sulfide concentrations increased while blood oxygen saturation remained similar raises questions about the quantity of hydrogen sulfide and metabolic fate of excess hydrogen sulfide in the blood of ruminant animals.

Pulse Oximetry and Breathing Training1

Biofeedback ◽  
2012 ◽  
Vol 40 (4) ◽  
pp. 137-141 ◽  
Author(s):  
Christopher Gilbert
Keyword(s):  
Oxygen Saturation ◽  
Pulse Oximetry ◽  
Medical Condition ◽  
Noninvasive Monitoring ◽  
Control Of Breathing ◽  
Oxygen Absorption ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Training Control ◽  
Pulse Oximeters

Small pulse oximeters have become widely available and can be useful for noninvasive monitoring of blood oxygen saturation by nonmedical personnel. When training control of breathing, an oximeter helps to reassure clients who hyperventilate that their oxygenation is adequate, offsetting their perception that they are not getting enough air. Low saturation may indicate a medical condition that impairs oxygen absorption. In that case, hyperventilation is a biological compensation that should not be tampered with.

Blood Oxygen Saturation Measurement Using Polarization-Dependent Optical Sectioning

2017 ◽  
Vol 17 (12) ◽  
pp. 3900-3908 ◽  
Author(s):  
Deepak Mishra ◽  
Neha Priyadarshini ◽  
Supriya Chakraborty ◽  
Mukul Sarkar
Keyword(s):  
Oxygen Saturation ◽  
Blood Oxygen ◽  
Optical Sectioning ◽  
Blood Oxygen Saturation ◽  
Saturation Measurement
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