scholarly journals Mesenchymal stem cell transplantation after acute myocardial infarction: a meta-analysis of clinical trials

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Armin Attar ◽  
Fateme Bahmanzadegan Jahromi ◽  
Shahin Kavousi ◽  
Ahmad Monabati ◽  
Asma Kazemi
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Clinical Outcomes ◽  
Primary Outcome ◽  
Meta Analysis ◽  
Cell Number ◽  
Time Interval ◽  
Mesenchymal Stem Cell Transplantation ◽  
And Control

Abstract Background Trials investigating the role of mesenchymal stem cells (MSCs) in increasing ejection fraction (LVEF) after acute myocardial infarction (AMI) have raised some controversies. This study was conducted to find whether transplantation of MSCs after AMI can help improve myocardial performance indices or clinical outcomes. Methods Randomized trials which evaluated transplantation of MSCs after AMI were enrolled. The primary outcome was LVEF change. We also assessed the role of cell origin, cell number, transplantation time interval after AMI, and route of cell delivery on the primary outcome. Results Thirteen trials including 956 patients (468 and 488 in the intervention and control arms) were enrolled. After excluding the biased data, LVEF was significantly increased compared to the baseline among those who received MSC (WMD = 3.78%, 95% CI: 2.14 to 5.42, p < 0.001, I2 = 90.2%) with more pronounced effect if the transplantation occurred within the first week after AMI (MD = 5.74%, 95%CI: 4.297 to 7.183; I2 = 79.2% p < 0.001). The efficacy of trans-endocardial injection was similar to that of intracoronary infusion (4% [95%CI: 2.741 to 5.259, p < 0.001] vs. 3.565% [95%CI: 1.912 to 5.218, p < 0.001], respectively). MSC doses of lower and higher than 107 cells did not improve LVEF differently (5.24% [95%CI: 2.06 to 8.82, p = 0.001] vs. 3.19% [95%CI: 0.17 to 6.12, p = 0.04], respectively). Conclusion Transplantation of MSCs after AMI significantly increases LVEF, showing a higher efficacy if done in the first week. Further clinical studies should be conducted to investigate long-term clinical outcomes such as heart failure and cardiovascular mortality.

scholarly journals CLINICAL OUTCOMES OF MANUAL ASPIRATION THROMBECTOMY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION: AN UPDATED META-ANALYSIS

2015 ◽  
Vol 65 (10) ◽  
pp. A1865
Author(s):  
Ashraf Mostafa ◽  
Alexandros Briasoulis ◽  
Luis Afonso ◽  
Ahmed Rashed ◽  
Mohan Palla ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Clinical Outcomes ◽  
Meta Analysis ◽  
Aspiration Thrombectomy

Cardioprotective role of ischemic postconditioning in acute myocardial infarction: A systematic review and meta-analysis

2014 ◽  
Vol 168 (4) ◽  
pp. 512-521.e4 ◽  
Author(s):  
Abdur Rahman Khan ◽  
Aref A. Binabdulhak ◽  
Yaseen Alastal ◽  
Sobia Khan ◽  
Bridget M. Faricy-Beredo ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Systematic Review ◽  
Acute Myocardial Infarction ◽  
Meta Analysis ◽  
Ischemic Postconditioning

scholarly journals Alexithymia Affects Pre-Hospital Delay of Patients with Acute Myocardial Infarction: Meta-Analysis of Existing Studies

2013 ◽  
Vol 9 (1) ◽  
pp. 69-73 ◽  
Author(s):  
Antonio Preti ◽  
Federica Sancassiani ◽  
Federica Cadoni ◽  
Mauro Giovanni Carta
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Help Seeking ◽  
Meta Analysis ◽  
Emotional Awareness ◽  
Preliminary Evidence ◽  
Critical Determinant ◽  
Seeking Help ◽  
Patient’S Outcome

Background: The time between the onset of symptoms and reperfusion is a critical determinant of the clinical course of patients with acute myocardial infarction (AMI). Any delay in seeking help will affect patient’s outcome. Alexithymia can influence the information processing but also the skills to detect the signal of an ongoing AMI. Method: Systematic review and meta-analysis of studies investigating the role of alexithymia in pre-hospital delay after AMI. Pubmed/Medline and PsychINFO/Ovid search from 1990 until 2012. Results: Out of 29 studies investigating the role of psychological factors in pre-hospital delay after AMI, 3 studies specifically assessed alexithymia, involving 258 patients. All studies used the Toronto Alexithymia Scale to group patients into clusters by time to presentation after AMI. Meta-analysis of data showed that the patients with higher emotional awareness (i.e., low alexithymia) had shorter time to presentation after AMI. Conclusions: Preliminary evidence indicates that alexithymia may have a role in seeking help delay after AMI. Further studies are necessary to better appreciate how alexithymia influence help-seeking in patients with an evolving AMI and in what extent their ineffective behavior can be changed.

scholarly journals Role of Neutrophil-Derived S100B in Acute Myocardial Infarction Patients From the Han Chinese Population

2021 ◽  
Vol 7 ◽  
Author(s):  
Minghui Cheng ◽  
Xu Su ◽  
Dan Liu ◽  
Xiaoxiang Tian ◽  
Chenghui Yan ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Artery ◽  
Chinese Population ◽  
Stable Angina Pectoris ◽  
Han Chinese Population ◽  
Qrt Pcr ◽  
Control Subjects ◽  
And Control

Objective: This study aimed to clarify the novel role of homeostatic calmodulin S100B and determined whether S100B genetic variants affected atherosclerosis progression in acute myocardial infarction (AMI) patients.Methods: Plasma levels of S100B were measured systemically in AMI patients, stable angina pectoris patients, and control subjects. S100B was obtained from the human coronary artery thrombi using a thrombectomy catheter and quantified via immunohistochemical analysis, qRT-PCR and Western blot analyse. We also screened for S100B variations (rs9722, rs9984765, rs2839356, rs1051169, and rs2186358) via direct sequencing, and investigated the relationship between these variants and AMI patients in the Chinese Han population.Results: Plasma S100B levels increased significantly in AMI patients compared to the levels in stable angina pectoris patients and control subjects (119.45 ± 62.46, 161.96 ± 73.30, and 312.91 ± 127.59 pg/ml, respectively). Immunohistochemical staining results showed that S100B expression was increased in the neutrophils of coronary artery thrombi obtained from AMI patients, as compared to that in normal blood clot, and S100B expression was significantly increased in fresh thrombi tissues, as compared to that in organized thrombi tissues. Western blot and qRT-PCR analysis showed that S100B expression increased in coronary artery thrombi, as compared to that in normal blood clots. After pre-treating the neutrophils with siRAGE, the neutrophils migration induced by S100B were abolished through the NFκB-IL1β/IL6 signaling pathway. Compared to their corresponding wild-type genotypes, the S100B rs9722 variant was associated with increased susceptibility to AMI (OR = 1.35, 95%CI: 1.12–1.65, P = 0.02). Individuals with the S100B 9722 A allele had higher plasma S100B levels than those with the G allele in control subjects and AMI patients (141.70 ± 76.69 vs. 107.31 ± 56.05 and 347.13 ± 148.94 vs. 273.05 ± 133.62, respectively).Conclusions: Levels of neutrophil-derived S100B, a novel homeostatic calmodulin, were elevated in the early stages of myocardial infarction. The S100B rs9722 allele was independently associated with AMI patients in the Han Chinese population.

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