scholarly journals Alexithymia Affects Pre-Hospital Delay of Patients with Acute Myocardial Infarction: Meta-Analysis of Existing Studies

2013 ◽  
Vol 9 (1) ◽  
pp. 69-73 ◽  
Author(s):  
Antonio Preti ◽  
Federica Sancassiani ◽  
Federica Cadoni ◽  
Mauro Giovanni Carta
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Help Seeking ◽  
Meta Analysis ◽  
Emotional Awareness ◽  
Preliminary Evidence ◽  
Critical Determinant ◽  
Seeking Help ◽  
Patient’S Outcome

Background: The time between the onset of symptoms and reperfusion is a critical determinant of the clinical course of patients with acute myocardial infarction (AMI). Any delay in seeking help will affect patient’s outcome. Alexithymia can influence the information processing but also the skills to detect the signal of an ongoing AMI. Method: Systematic review and meta-analysis of studies investigating the role of alexithymia in pre-hospital delay after AMI. Pubmed/Medline and PsychINFO/Ovid search from 1990 until 2012. Results: Out of 29 studies investigating the role of psychological factors in pre-hospital delay after AMI, 3 studies specifically assessed alexithymia, involving 258 patients. All studies used the Toronto Alexithymia Scale to group patients into clusters by time to presentation after AMI. Meta-analysis of data showed that the patients with higher emotional awareness (i.e., low alexithymia) had shorter time to presentation after AMI. Conclusions: Preliminary evidence indicates that alexithymia may have a role in seeking help delay after AMI. Further studies are necessary to better appreciate how alexithymia influence help-seeking in patients with an evolving AMI and in what extent their ineffective behavior can be changed.

Cardioprotective role of ischemic postconditioning in acute myocardial infarction: A systematic review and meta-analysis

2014 ◽  
Vol 168 (4) ◽  
pp. 512-521.e4 ◽  
Author(s):  
Abdur Rahman Khan ◽  
Aref A. Binabdulhak ◽  
Yaseen Alastal ◽  
Sobia Khan ◽  
Bridget M. Faricy-Beredo ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Systematic Review ◽  
Acute Myocardial Infarction ◽  
Meta Analysis ◽  
Ischemic Postconditioning

scholarly journals Mesenchymal stem cell transplantation after acute myocardial infarction: a meta-analysis of clinical trials

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Armin Attar ◽  
Fateme Bahmanzadegan Jahromi ◽  
Shahin Kavousi ◽  
Ahmad Monabati ◽  
Asma Kazemi
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Clinical Outcomes ◽  
Primary Outcome ◽  
Meta Analysis ◽  
Cell Number ◽  
Time Interval ◽  
Mesenchymal Stem Cell Transplantation ◽  
And Control

Abstract Background Trials investigating the role of mesenchymal stem cells (MSCs) in increasing ejection fraction (LVEF) after acute myocardial infarction (AMI) have raised some controversies. This study was conducted to find whether transplantation of MSCs after AMI can help improve myocardial performance indices or clinical outcomes. Methods Randomized trials which evaluated transplantation of MSCs after AMI were enrolled. The primary outcome was LVEF change. We also assessed the role of cell origin, cell number, transplantation time interval after AMI, and route of cell delivery on the primary outcome. Results Thirteen trials including 956 patients (468 and 488 in the intervention and control arms) were enrolled. After excluding the biased data, LVEF was significantly increased compared to the baseline among those who received MSC (WMD = 3.78%, 95% CI: 2.14 to 5.42, p < 0.001, I2 = 90.2%) with more pronounced effect if the transplantation occurred within the first week after AMI (MD = 5.74%, 95%CI: 4.297 to 7.183; I2 = 79.2% p < 0.001). The efficacy of trans-endocardial injection was similar to that of intracoronary infusion (4% [95%CI: 2.741 to 5.259, p < 0.001] vs. 3.565% [95%CI: 1.912 to 5.218, p < 0.001], respectively). MSC doses of lower and higher than 107 cells did not improve LVEF differently (5.24% [95%CI: 2.06 to 8.82, p = 0.001] vs. 3.19% [95%CI: 0.17 to 6.12, p = 0.04], respectively). Conclusion Transplantation of MSCs after AMI significantly increases LVEF, showing a higher efficacy if done in the first week. Further clinical studies should be conducted to investigate long-term clinical outcomes such as heart failure and cardiovascular mortality.

scholarly journals Surviving to Acute Myocardial Infarction: The Role of Psychological Factors and Alexithymia in Delayed Time to Searching Care: A Systematic Review

2021 ◽  
Vol 10 (17) ◽  
pp. 3813
Author(s):  
Federica Sancassiani ◽  
Roberta Montisci ◽  
Antonio Preti ◽  
Pasquale Paribello ◽  
Luigi Meloni ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Psychological Factors ◽  
Myocardial Salvage ◽  
Care Seeking ◽  
Critical Determinant ◽  
Time Period ◽  
Care Seeking Behavior ◽  
Seeking Behavior

The time from symptom onset to reperfusion is a critical determinant of myocardial salvage and clinical outcomes in patients with acute myocardial infarction (AMI). This time period could be delayed if people do not seek help promptly and/or if the health system is not efficient in responding quickly and attending to these individuals. The aim of this study was to identify psychological factors associated with pre-hospital delay (PHD) or patients’ decisional delay (PDD) in people with an ongoing AMI. A search in PubMed/Medline from 1990 to 2021 with the keywords “pre-hospital delay” OR “prehospital delay” OR “patient delay” OR “decisional delay” OR “care seeking behavior” AND “psychological factors” OR “alexithymia” AND “myocardial infarction” was performed. Thirty-six studies were included, involving 10.389 patients. Wrong appraisal, interpretation and causal beliefs about symptoms, denial of the severity of the symptoms and high levels of alexithymia were found related to longer PHD or PDD. Alexithymia may be an overarching construct that explains the disparate findings of the studies exploring the role of psychological factors in PHD or PDD. Further studies are needed in order to analyse the role of alexithymia in patients with risk factors for AMI to prevent delay.

scholarly journals The Role of Micro RNAs (miRNAs) in Early Detection of Acute Myocardial Infarction: A Meta-Analysis

2016 ◽  
Vol 1 (3) ◽  
Author(s):  
Chunyu Li ◽  
Jun Chen ◽  
Kamiljan Tursun ◽  
Alimjan Ablimit ◽  
Xi Zhang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Early Detection ◽  
Meta Analysis ◽  
Micro Rnas
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