scholarly journals Antitumor potential of the myotoxin BthTX-I from Bothrops jararacussu snake venom: evaluation of cell cycle alterations and death mechanisms induced in tumor cell lines

2015 ◽  
Vol 21 (1) ◽  
Author(s):  
Cássio Prinholato da Silva ◽  
Tássia R. Costa ◽  
Raquel M. Alves Paiva ◽  
Adélia C. O. Cintra ◽  
Danilo L. Menaldo ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Cell ◽  
Cell Lines ◽  
Snake Venom ◽  
Tumor Cell Lines ◽  
Bothrops Jararacussu ◽  
Antitumor Potential ◽  
Cell Cycle Alterations

Artificial Zinc(II) Complexes Regulate Cell Cycle and Apoptosis-Related Genes in Tumor Cell Lines

ChemBioChem ◽  
2007 ◽  
Vol 8 (3) ◽  
pp. 332-340 ◽  
Author(s):  
Jian Gao ◽  
Ya-Guang Liu ◽  
Yaqing Zhou ◽  
Linda M. Boxer ◽  
F. Ross Woolley ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Cell ◽  
Cell Lines ◽  
Tumor Cell Lines

Evaluation of Effect of Triterpenes and Limonoids on Cell Growth, Cell Cycle and Apoptosis in Human Tumor Cell Lines

2010 ◽  
Vol 10 (10) ◽  
pp. 769-776 ◽  
Author(s):  
Cristiane M. Cazal ◽  
Kantima Choosang ◽  
Vanessa Gisele P. Severino ◽  
Marcio S. Soares ◽  
Andre Lucio F. Sarria ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Tumor Cell ◽  
Cell Lines ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines

The influence of Cremophor EL on the cell cycle effects of paclitaxel (Taxol�) in human tumor cell lines

1994 ◽  
Vol 33 (4) ◽  
pp. 331-339 ◽  
Author(s):  
James Liebmann ◽  
John A. Cook ◽  
Claudia Lipschultz ◽  
Diane Teague ◽  
Joyce Fisher ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Cell ◽  
Cell Lines ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Cremophor El ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines

4‐Deoxyraputindole C induces cell death and cell cycle arrest in tumor cell lines

2018 ◽  
Vol 120 (6) ◽  
pp. 9608-9623 ◽  
Author(s):  
Wagner D. Vital ◽  
Heron F. V. Torquato ◽  
Larissa de Oliveira Passos Jesus ◽  
Wagner Alves de Souza Judice ◽  
Maria Fátima das G. F. da Silva ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Death ◽  
Tumor Cell ◽  
Cell Cycle Arrest ◽  
Cell Lines ◽  
Tumor Cell Lines ◽  
Cycle Arrest

l-Amino acid oxidase from Cerastes vipera snake venom: Isolation, characterization and biological effects on bacteria and tumor cell lines

Toxicon ◽  
2018 ◽  
Vol 150 ◽  
pp. 270-279 ◽  
Author(s):  
Walaa H. Salama ◽  
Nihal M. Ibrahim ◽  
Amr E. El Hakim ◽  
Roqaya I. Bassuiny ◽  
Manal M. Mohamed ◽  
...  
Keyword(s):  
Amino Acid ◽  
Tumor Cell ◽  
Cell Lines ◽  
Snake Venom ◽  
Biological Effects ◽  
Acid Oxidase ◽  
Tumor Cell Lines ◽  
Amino Acid Oxidase

Chromatin-association of the Polycomb group protein BMI1 is cell cycle-regulated and correlates with its phosphorylation status

1999 ◽  
Vol 112 (24) ◽  
pp. 4627-4639 ◽  
Author(s):  
J.W. Voncken ◽  
D. Schweizer ◽  
L. Aagaard ◽  
L. Sattler ◽  
M.F. Jantsch ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Cell ◽  
Cell Lines ◽  
Mammalian Cells ◽  
Polycomb Group ◽  
Chromatin Interaction ◽  
Tumor Cell Lines ◽  
Polycomb Group Protein ◽  
Mitotic Chromosomes ◽  
Grain Distribution

The human proto-oncogene Bmi1 is a member of the mammalian Polycomb Group (Pc-G) genes. The subnuclear distribution of the BMI1 protein was studied in several primary human and tumor-derived cell lines using immunohistochemical and biochemical methods. In primary and tumor cells, nuclear BMI1 shows a fine-grain distribution over chromatin, usually dense in interphase nuclei and significantly weaker along mitotic chromosomes. In addition, BMI1 preferentially associates with several distinct heterochromatic domains in tumor cell lines. In both primary and tumor cell lines a marked cell cycle-regulation of Pc-G-chromatin interaction is observed: nuclear BMI1-staining dissipates in late S phase and is re-established early in G(1)-phase. Chromatin-association of BMI1 inversely correlates with its phosphorylation status in a cell cycle-dependent fashion: at G(1)/S, hypophosphorylated BMI1 is specifically retained in the chromatin-associated nuclear protein fraction, whereas during G(2)/M, phosphorylated BMI1 is not chromatin-bound. Our findings indicate a strict cell cycle-controlled regulation of Pc-G complex-chromatin association and provide molecular tools for improving our understanding of Pc-G complex regulation and function in mammalian cells.

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