scholarly journals Leiomyosarcoma of urinary bladder with unusual recurrence in intestinal mucosa and peritoneum: a case report

Author(s):  
Poorva Vias ◽  
Shikha Goyal ◽  
Kannan Periasamy ◽  
Renu Madan ◽  
Sudheer Kumar Devana ◽  
...  

Abstract Background Leiomyosarcomas of urinary bladder constitute rare malignant sarcomas with very few cases reported in literature. Case presentation Here, we present a case of bladder leiomyosarcoma in a well-preserved female. She failed to respond to standard chemotherapy and had a rapidly downhill course with unusual metastases in anastomotic site and peritoneum soon after surgery. Despite multimodality management including resection of primary and metastatic site, systemic therapy and pelvic radiotherapy, our patient had dismal prognosis with an overall survival of 1.7 years. Conclusion Leiomyosarcomas of bladder are aggressive tumors and have a very poor prognosis; thus, future research should focus on optimizing more effective treatment regimes.

2002 ◽  
Vol 55 (2) ◽  
pp. 242-248 ◽  
Author(s):  
Guido Costamagna ◽  
Saumil K. Shah ◽  
Massimiliano Mutignani ◽  
Andrea Tringali ◽  
Petros P. Alevras ◽  
...  

2021 ◽  
Vol 27 (1) ◽  
Author(s):  
Jai Kumar ◽  
Mohammad Irfaan Albeerdy ◽  
Nadeem Ahmed Shaikh ◽  
Abdul Hafeez Qureshi

Abstract Background Peutz-Jeghers syndrome is an autosomal dominant disease characterized by mucocutaneous pigmentation and hamartomatous polyps in the gastrointestinal tract (GIT). There have also been cases of extra GIT polyps such as the renal pelvis, urinary bladder, lungs and nares. Bladder hamartoma is an extremely rare finding, with only 12 cases described in the literature up to now. The rarity of the condition necessitates a comprehensive compilation of managements up to now so as to provide a better tool for the treatment of such conditions in the future. Case presentation A twenty-year-old male, known to have Peutz-Jeghers syndrome, presented to us complaining of obstructive urinary symptoms. A urethrogram done showed a filling defect at the base of the urinary bladder. The mass was resected transurethrally, and histopathology revealed a hamartoma of the bladder. The patient has since remained tumor-free on follow-up. Conclusions Transurethral resection of the bladder mass proved to be an effective therapy in this patient with no recurrence on the patient’s follow-up till now. There is still, however, a dearth of knowledge regarding the management of bladder hamartomas owing to the extreme rarity of the case.


2018 ◽  
Vol 18 ◽  
pp. 29-30 ◽  
Author(s):  
E.E. Bakurov ◽  
D.V. Krakhotkin ◽  
O.B. Kucherenko

2016 ◽  
Vol 21 (4) ◽  
pp. 172-174
Author(s):  
Seda O. Nikogosyan ◽  
T. Sh Tagibova ◽  
V. V Kuznetsov ◽  
O. A Anurova

Diagnostics and treatment of female reproductive system tumors with Merkel cell phenotype, rare aggressive tumors with dismal prognosis, is under consideration in this article. Only 20 cases of Merkel cell vulvar carcinoma and 1 case of Merkel cell vagina cancer were described in the literature. Diagnostics must include immunohistochemical analysis, as expression of cytokeratine 20 proves to be the most typical factor. Polyomavirus infection is believed to be associated with the disease pathogenesis. No treatment standards were accepted due to the rarity of the disease. Considering the data on tumor radiosensitivity, the treatment must include radio- or chemoradiotherapy.


2011 ◽  
Vol 2011 ◽  
pp. 1-3
Author(s):  
Christos Zachariadis ◽  
Ioannis Efthimiou ◽  
Stylianos Giannakopoulos ◽  
Athanasios Bantis ◽  
Alexandra Giatromanolaki ◽  
...  

Carcinosarcoma of the bladder is an unusual tumour characterized by a combination of malignant epithelial and soft tissue elements. Most of the reported cases have been case reports or small series. Optimal treatment is uncertain. We herein report our experience in such a case treated with transurethral resection followed by radiotherapy with adverse final outcome. Treatment of bladder carcinosarcomas should be aggressive and multimodal but optional treatment is still unknown. Radiotherapy alone is insufficient as a treatment option of these aggressive tumors.


2017 ◽  
Vol 7 (3) ◽  
pp. 712-718 ◽  
Author(s):  
Jennifer Tingo ◽  
Erika B. Rosenzweig ◽  
Steven Lobritto ◽  
Usha S. Krishnan

Portopulmonary hypertension (PoPH) is defined by the combination of portal hypertension and precapillary pulmonary arterial hypertension (PAH). Very little is known about this process in pediatric patients but prognosis is generally poor. We review our institutional experience and report on five patients with pediatric PoPH. The median age of PoPH diagnosis was six years and PAH was 14 years. PAH diagnosis was made by echocardiogram in all patients, four of whom also had cardiac catheterization. The median mean pulmonary artery pressure (mPAP) was 48.5 mmHg (interquartile range [IQR] = 46–60) with a median pulmonary vascular resistance index (PVRi) of 9 WU*M2 (IQR = 8–22). All were acute pulmonary vasodilator testing non-responsive. All patients received targeted therapies. Three of five patients (60%) died despite an evidence-based approach to care. Of those who died, timing from the PoPH diagnosis to death ranged from three days to three years. Based upon our limited experience, PoPH is a disorder with significant mortality in childhood and challenges in treatment. Future research, focused on screening and early targeted treatment strategies, may alter the current dismal prognosis for these children.


2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Amir Shahram Yousefi Kashi ◽  
Farzad Taghizadeh-Hesary

Introduction: Post-irradiation mammary stromal sarcoma (MSS) is a rare condition, and it is worth learning new knowledge from each case. Case Presentation: We present the case report of a 59-year-old female with a medical history of breast cancer, who presented with an axillary mass on the same side. The patient was further evaluated and finally diagnosed with MSS with chondroid differentiation. Thereafter, she underwent neoadjuvant chemotherapy to facilitate the surgical resection of the tumor. However, she experienced local progression and lung metastasis during chemotherapy. Conclusions: MSS with chondroid differentiation was resistant to the standard chemotherapy regimens of sarcoma. Radiotherapy is a potential choice in the case of chemoresistant MSS. Further trials may reveal this notion.


Author(s):  
Charles Odongo ◽  
raymond atwine ◽  
Martin Situma ◽  
ambrose okello ◽  
eugene ogwang ◽  
...  

Introduction: Cavernous hemangioma accounts for 0.6% of bladder tumors. We present a rare case Case Presentation: A 3-year-old girl presented with intravaginal swelling, dysuria, and hematuria. She received 26 cycles of VAC for embryonal rhabdomyosarcoma. Histopathology confirmed CH. Conclusion: CH should be considered in the differentials of childhood genitourinary masses.


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