Prevalence and predictors of urinary tract infection in full-term and preterm neonates

To the Editor.— Two years ago Roland et al reviewed a group of full-term newborns with late-onset thalamic hemorrhage/intraventricular bleeding.1 The pathogenesis of this condition remains unclear but in the series of patients described by Roland et al, we noticed that urinary tract infection was the most common complicating factor. We recently treated a full-term newborn with late-onset unilateral thalamic hemorrhage associated with a urinary tract infection. The child was born after an uncomplicated pregnancy at 40 weeks of gestation.

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Urinary tract infection among neonatal sepsis of late-onset in Cipto Mangunkusumo Hospital

Paediatrica Indonesiana ◽

10.14238/pi45.5.2005.217-22 ◽

2016 ◽

Vol 45 (5) ◽

pp. 217 ◽

Cited By ~ 1

Author(s):

Novie Amelia ◽

Idham Amir ◽

Partini P Trihono

Keyword(s):

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Neonatal Sepsis ◽

Urine Culture ◽

Late Onset ◽

Preterm Neonates ◽

Cross Sectional ◽

Female Ratio ◽

Late Onset Sepsis

Background Urine culture, as part of a full septic work-up forlate-onset neonatal sepsis, was not routinely done in the Neona-tal Ward at Cipto Mangunkusumo Hospital, and as of today, theprevalence of urinary tract infection (UTI) among neonates withlate-onset sepsis remains unknown.Objectives To determine the prevalence and microbiological pat-terns of UTI among late-onset neonatal sepsis in CiptoMangunkusumo Hospital.Methods We conducted a cross-sectional study on all neonatesdiagnosed as suspected late-onset sepsis who underwent sep-sis evaluation between 20 October 2003 – 30 April 2004. Urinespecimens were collected by bladder catheterization for cultureand urinalysis.Results UTI was found in 14.9% (7/47) neonates who under-went urine culture (male: female ratio was 5:2). Six subjectswho had UTI were preterm neonates, Klebsiella pneumoniaewas found in both blood and urine cultures of 1 subject, while theothers showed different microorganisms. Forty-five out of 47subjects, who were suspected of late-onset sepsis, had posi-tive blood cultures. All subjects with UTI had positive bacteriuriafrom Gram-stained specimen.Conclusions The prevalence of UTI among neonates with late-onset sepsis in Cipto Mangunkusumo Hospital was 14.9%. Themicroorganisms most frequently found in urine cultures werePseudomonas sp., Staphylococcus epidermidis, and Klebsiellapneumoniae. Urine culture, urinalysis, and urinary Gram-stainshould be performed as part of sepsis evaluation for late-onsetneonatal sepsis, especially in male and preterm neonates

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Late-onset sepsis due to urinary tract infection in very preterm neonates is not uncommon

European Journal of Pediatrics ◽

10.1007/s00431-017-3030-9 ◽

2017 ◽

Vol 177 (1) ◽

pp. 33-38 ◽

Cited By ~ 7

Author(s):

Alexander B. Mohseny ◽

Veerle van Velze ◽

Sylke J. Steggerda ◽

Vivianne E. H. J. Smits-Wintjens ◽

Vincent Bekker ◽

...

Keyword(s):

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Late Onset ◽

Preterm Neonates ◽

Very Preterm ◽

Late Onset Sepsis

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Urinary tract infection in full-term newborn infants: value of urine culture by bag specimen collection

Revista do Hospital das Clínicas ◽

10.1590/s0041-87811999000300005 ◽

1999 ◽

Vol 54 (3) ◽

pp. 91-96 ◽

Cited By ~ 5

Author(s):

Mário Cícero Falcão ◽

Cléa Rodrigues Leone ◽

Renata A. P. D'Andrea ◽

Roberta Berardi ◽

Nilce A. Ono ◽

...

Keyword(s):

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Urine Culture ◽

Newborn Infants ◽

Full Term ◽

Positive Urine Culture ◽

Term Newborn ◽

Specimen Collection ◽

Positive Urine

OBJETIVE: to evaluate the efficacy of urine culture by bag specimen for the detection of neonatal urinary tract infection in full-term newborn infants. Retrospective study (1997) including full-term newborn infants having a positive urine culture (>100,000 CFU/ml) by bag specimen collection. The urinary tract infection diagnosis was confirmed by positive urine culture (suprapubic bladder aspiration method). The select cases were divided into three groups, according to newborn infant age at the bag specimen collection: GI (< 48 h, n = 17), GII (48 h to 7 d, n = 35) and GIII (> 7 d, n = 9). Sixty one full-term newborn infants were studied (5.1 % of total infants). The diagnosis was confirmed on 19/61 (31.1 %) of full-term infants born alive. Distribution among the groups was: GI = 2/17 (11.8 %), GII = 10//35 (28.6 %), and GIII = 7/9 (77.7 %). The most relevant clinical symptoms were: fever (GI - 100 %, GII - 91.4 %) and weight loss (GI - 35.3 %, GII - 45.7 %). Urine culture results for specimens collected by suprapubic aspiration were: E. coli GI (100 %), GII (40 %) and GIII (28.6 %), E. faecalis GI (30%), Staphylococcus coagulase-negative GII (20 %) and GIII (42.8 %), and Staphylococcus aureus GII (10 %). Correlation between positive urine culture collection (bag specimen method) and urinary tract infection diagnosis, using relative risk analysis, produced the following results: GI=0.30 (CI95% 0.08-1.15), GII=0.51 (CI 95% 0.25-1.06) and GIII=3.31 (CI95% 1.8-6.06) The most frequent urinary tract infection clinical signs in the first week were fever and weight loss, while non-specific symptomatology occurred later. E. coli was most frequent infectious agent, although from the 7th day of life, staphylococcus was noted. The urine culture (bag specimen method) was effective in detecting urinary tract infection only after the 7th day of life.

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