scholarly journals Human pluripotent stem cell-derived cardiomyocytes for heart regeneration, drug discovery and disease modeling: from the genetic, epigenetic, and tissue modeling perspectives

2013 ◽  
Vol 4 (4) ◽  
pp. 97 ◽  
Author(s):  
Maggie Chow ◽  
Kenneth R Boheler ◽  
Ronald A Li
Keyword(s):  
Stem Cell ◽  
Drug Discovery ◽  
Pluripotent Stem Cell ◽  
Disease Modeling ◽  
Heart Regeneration ◽  
Human Pluripotent Stem Cell ◽  
Tissue Modeling

scholarly journals Human Pluripotent Stem Cell-Derived Cardiac Cells: Application in Disease Modeling, Cell Therapy, and Drug Discovery

2021 ◽  
Vol 9 ◽  
Author(s):  
Juan Huang ◽  
Qi Feng ◽  
Li Wang ◽  
Bingying Zhou
Keyword(s):  
Stem Cell ◽  
Drug Discovery ◽  
Cell Therapy ◽  
Pluripotent Stem Cell ◽  
Disease Modeling ◽  
Three Dimensional ◽  
Cardiac Cells ◽  
Cardiac Diseases ◽  
Human Pluripotent Stem Cell ◽  
Species Specific

Cardiac diseases are the leading cause of deaths worldwide; however, to date, there has been limited progress in the development of therapeutic options for these conditions. Animal models have been the most extensively studied methods to recapitulate a wide variety of cardiac diseases, but these models exhibit species-specific differences in physiology, metabolism and genetics, which lead to inaccurate and unpredictable drug safety and efficacy results, resulting in drug attrition. The development of human pluripotent stem cell (hPSC) technology in theory guarantees an unlimited source of human cardiac cells. These hPSC-derived cells are not only well suited for traditional two-dimensional (2-D) monoculture, but also applicable to more complex systems, such as three-dimensional (3-D) organoids, tissue engineering and heart on-a-chip. In this review, we discuss the application of hPSCs in heart disease modeling, cell therapy, and next-generation drug discovery. While the hPSC-related technologies still require optimization, their advances hold promise for revolutionizing cell-based therapies and drug discovery.

scholarly journals Perspective on human pluripotent stem cell‐derived cardiomyocytes in heart disease modeling and repair

2020 ◽  
Vol 9 (10) ◽  
pp. 1121-1128
Author(s):  
Qiang Li ◽  
Jia Wang ◽  
Qiang Wu ◽  
Nan Cao ◽  
Huang‐Tian Yang
Keyword(s):  
Stem Cell ◽  
Heart Disease ◽  
Pluripotent Stem Cell ◽  
Disease Modeling ◽  
Human Pluripotent Stem Cell

scholarly journals Human pluripotent stem cell-derived cardiomyocyte based models for cardiotoxicity and drug discovery

2016 ◽  
Vol 15 (11) ◽  
pp. 1455-1458 ◽  
Author(s):  
Yimu Zhao ◽  
Anastasia Korolj ◽  
Nicole Feric ◽  
Milica Radisic
Keyword(s):  
Stem Cell ◽  
Drug Discovery ◽  
Pluripotent Stem Cell ◽  
Human Pluripotent Stem Cell

scholarly journals Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids

2021 ◽  
Author(s):  
Takahiro Suezawa ◽  
Shuhei Kanagaki ◽  
Keita Moriguchi ◽  
Atsushi Masui ◽  
Kazuhisa Nakao ◽  
...  
Keyword(s):  
Stem Cell ◽  
Pulmonary Fibrosis ◽  
Pluripotent Stem Cell ◽  
Disease Modeling ◽  
Human Pluripotent Stem Cell
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