Plasma Magnesium and Calcium Levels in Depressive Psychosis

1972 ◽  
Vol 120 (559) ◽  
pp. 683-684 ◽  
Author(s):  
G. J. Naylor ◽  
Laura W. Fleming ◽  
W. K. Stewart ◽  
H. B. McNamee ◽  
D. Le Poidevin
Keyword(s):  
Divalent Cation ◽  
Calcium Concentration ◽  
Depressive Illness ◽  
Plasma Calcium ◽  
Ionized Calcium ◽  
Total Plasma ◽  
Total Calcium ◽  
Before And After ◽  
Plasma Calcium Concentration ◽  
Plasma Magnesium

There have been reports of the association of alterations in the divalent cation content of plasma with depressive illness. Coirault and colleagues (1959) found increased ionized calcium levels despite decreased total plasma calcium concentration in patients recovered from depression. More recently, Frizel and colleagues (1969) have reported normal plasma ionized and total calcium levels both before and after recovery from depression.

Plasma Magnesium and Calcium in Depression

1969 ◽  
Vol 115 (529) ◽  
pp. 1375-1377 ◽  
Author(s):  
D. Frizel ◽  
Alec Coppen ◽  
V. Marks
Keyword(s):  
Affective Disorders ◽  
Plasma Concentrations ◽  
Lithium Carbonate ◽  
Depressive Illness ◽  
Plasma Calcium ◽  
Total Plasma ◽  
Depressed Patients ◽  
Before And After ◽  
Calcium And Magnesium ◽  
Plasma Magnesium

Recent investigations suggest that there may be an abnormality of calcium and magnesium in depressive illness. Flach (1964) followed the urinary excretion of calcium in depressed patients maintained on a constant intake of calcium before and during recovery. Those patients that recovered showed a significant decrease in the excretion of calcium. Coiraultet al.(1959) reported an increase in ionized calcium and a decrease in total plasma calcium on recovery from depression. Cade (1964) reported considerably raised total plasma magnesium levels in depressed patients both before and after recovery. A connection between affective disorders and calcium metabolism is suggested by the common occurrence of such states in both hypo- and hypercalcaemia (Denco and Kaelbling, 1962; Rookus and Speelman, 1961). The present paper reports an investigation into total and ionized plasma calcium and magnesium in a group of depressed patients both before and after recovery. The effects of lithium carbonate, a compound used in the treatment and prophylaxis of affective disorders (Baastrup and Schou, 1967; Schou, 1963) on plasma concentrations of magnesium and calcium was also investigated.

ABOLITION OF MAGNESIUM-INDUCED HYPOCALCAEMIA BY ACUTE THYRO-PARATHYROIDECTOMY IN THE CAT

1970 ◽  
Vol 64 (1) ◽  
pp. 150-158 ◽  
Author(s):  
S. Pors Nielsen
Keyword(s):  
Sodium Chloride ◽  
Flow Rate ◽  
Magnesium Chloride ◽  
Calcium Concentration ◽  
Plasma Calcium ◽  
Magnesium Concentration ◽  
Isotonic Sodium Chloride ◽  
Plasma Calcium Concentration ◽  
High Concentrations ◽  
Plasma Magnesium

ABSTRACT Intravenous infusion of isotonic magnesium chloride into young cats with a resultant mean plasma magnesium concentration of 7.7 meq./100 g protein was followed by a significant lowering of the plasma calcium concentration in 90 minutes. The rate of decrease of plasma calcium is consistent with the hypothesis that calcitonin is released by magnesium in high concentrations. There was no decrease in the plasma calcium concentration in cats of the same weight thyroparathyroidectomized 60 min before an identical magnesium chloride infusion or an infusion of isotonic sodium chloride at the same flow rate. The hypercalciuric effect of magnesium could not account for the hypocalcaemic effect of magnesium. Plasma magnesium concentration during magnesium infusion into cats with an intact thyroid-parathyroid gland complex was slightly, but not significantly higher than in acutely thyroparathyroidectomized cats.

CALCIUM AND THE CONTROL OF CIRCADIAN MITOTIC ACTIVITY IN RAT BONE MARROW AND THYMUS

1974 ◽  
Vol 62 (3) ◽  
pp. 451-462 ◽  
Author(s):  
N. H. HUNT ◽  
A. D. PERRIS
Keyword(s):  
Bone Marrow ◽  
Mitotic Activity ◽  
Calcium Homeostasis ◽  
Calcium Concentration ◽  
Plasma Calcium ◽  
Ionized Calcium ◽  
Plasma Phosphate ◽  
Circadian Changes ◽  
Plasma Calcium Concentration ◽  
Rat Bone

SUMMARY Circadian changes in mitotic activity in rat bone marrow and thymus have been demonstrated to closely parallel variations in total and ionized calcium concentrations in plasma. These fluctuations in plasma calcium concentration and tissue mitosis were abolished by parathyroidectomy. Significant changes in plasma phosphate and magnesium concentrations were also observed over the 24 h period. The evidence suggests that hour-to-hour variations in the systems controlling calcium homeostasis determine the levels of mitosis in rat bone marrow and thymus.

scholarly journals STANNIECTOMY INCREASES RENAL MAGNESIUM AND CALCIUM EXCRETION IN FRESHWATER NORTH AMERICAN EELS (ANGUILLA ROSTRATA)

1993 ◽  
Vol 181 (1) ◽  
pp. 107-118
Author(s):  
D. G. Butler
Keyword(s):  
North American ◽  
Calcium Concentration ◽  
Urinary Calcium ◽  
Plasma Calcium ◽  
Magnesium Concentration ◽  
Calcium Excretion ◽  
Plasma Calcium Concentration ◽  
Magnesium Excretion ◽  
Plasma Magnesium ◽  
American Eels

The corpuscles of Stannius are linked to the renal transport of magnesium in freshwater North American eels. The urinary magnesium concentration and rate of magnesium excretion increased 3 days after the corpuscles had been removed, a trend which continued throughout a 14 day observation period. There was no overall change in urine flow rates except for a brief 50 % reduction 2 days after stanniectomy. Plasma magnesium concentrations drifted downward after stanniectomy. In contrast, plasma calcium concentrations increased significantly within 2 days following stanniectomy and they continued to increase thereafter. Urinary calcium concentrations and the rate of urinary calcium excretion increased 7 days after stanniectomy, implying that the renal response was subject to the increase in plasma calcium concentration: the urine/plasma calcium ratio remained constant. Even though the urinary calcium concentration increased after stanniectomy, the increase in urinary magnesium concentration was proportionally greater.

Platelet cytosolic free calcium concentration, total plasma calcium concentration and blood pressure in human twins: a genetic analysis

1992 ◽  
Vol 82 (5) ◽  
pp. 493-504 ◽  
Author(s):  
P. D. Williams ◽  
I. B. Puddey ◽  
N. G. Martin ◽  
L. J. Beilin
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Calcium Concentration ◽  
Plasma Calcium ◽  
Free Calcium ◽  
Total Plasma ◽  
Cytosolic Free Calcium ◽  
Plasma Calcium Concentration ◽  
Free Calcium Concentration ◽  
Cytosolic Free Calcium Concentration

1. We used path analysis and maximum-likelihood model fitting to evaluate the relative contributions of genetic and environmental factors to the relationships observed between level of blood pressure and both total plasma calcium concentration and platelet cytosolic free calcium concentration in 109 twin pairs. 2. Total plasma calcium concentration was positively associated with systolic (r = 0.26, P < 0.001) but not diastolic blood pressure, a relationship which remained significant after adjustment for albumin, age and body mass index. A relationship between platelet cytosolic free calcium concentration and both systolic and diastolic blood pressure (r=0.17 and r=0.13, respectively, P ≤ 0.05) was no longer significant after adjustment for age and body mass index. 3. Additive genetic influences, unique environmental effects and age contributed to 60%, 30% and 10% of the variance in systolic blood pressure, respectively. Additive genetic effects explained 78% of the variance in plasma total calcium concentration and at least 48% of the variance in platelet cytosolic free calcium concentration in females and 37% in males. 4. Bivariate factor models provided evidence of genetic, but not environmental, co-variation of total plasma calcium concentration and systolic blood pressure, suggesting that a common genetic factor (or factors) contributes to their univariate relationship. In contrast, there was evidence of environmental, but not genetic, covariation of platelet cytosolic free calcium concentration and systolic blood pressure, suggesting that some of the individual experiences specific to each twin may be causing these two traits to vary together. 5. The possible confounding effects of adiposity and environmental factors should be considered in future studies investigating the role of intracellular calcium levels in the pathogenesis of hypertension.

Plasma Ultrafiltrable Calcium in Respiratory Alkalosis and Acidosis

1957 ◽  
Vol 190 (3) ◽  
pp. 459-461 ◽  
Author(s):  
Ananda S. Prasad ◽  
E. B. Brown ◽  
E. B. Flink
Keyword(s):  
Calcium Concentration ◽  
Respiratory Acidosis ◽  
Respiratory Alkalosis ◽  
Recovery Phase ◽  
Plasma Calcium ◽  
Positive Pressure ◽  
Total Plasma ◽  
Arterial Blood ◽  
Plasma Calcium Concentration ◽  
Rebound Increase

Dogs were subjected to either 30 minutes of respiratory alkalosis produced by overventilating with a positive pressure pump, or to 30 minutes of respiratory acidosis produced by inhalation of 30% CO2 in O2. Total plasma calcium concentration and ultrafiltrable calcium concentrations were determined on arterial blood samples drawn before, during and following the experimental procedure. In agreement with theory, ultrafiltrable calcium concentration decreased slightly during hyperventilation and increased during respiratory acidosis. A rebound increase in the level of ultrafiltrable calcium in the recovery phase following hyperventilation and a similar but inverse rebound following respiratory acidosis was observed in every case. It is postulated that these changes may be due to concomitant changes in plasma phosphate concentration. Total proteins and fractionated proteins did not show consistent changes in these experiments which could account for the changes observed in the ultrafiltrable calcium concentration. The significant changes in ultrafiltrable calcium concentration observed in these experiments would not be apparent if only total calcium concentration were determined since total plasma calcium concentration changed very little or not at all.

Parathyroid Hormone-like Biological Activity in Urine

1978 ◽  
Vol 54 (4) ◽  
pp. 349-353 ◽  
Author(s):  
N. Nijs-De Wolf ◽  
N. De Nutte ◽  
H. Brauman ◽  
J. Corvilain
Keyword(s):  
Biological Activity ◽  
Parathyroid Hormone ◽  
Secondary Hyperparathyroidism ◽  
Calcium Concentration ◽  
Normal Volunteer ◽  
Normal Subjects ◽  
Plasma Calcium ◽  
Surgical Removal ◽  
Before And After ◽  
Plasma Calcium Concentration

1. The parathyroid hormone-like biological activity of concentrated urine was measured by the increase of plasma calcium concentration after intravenous injection of the sample into chickens. 2. Urine was tested in hypoparathyroid patients, normal volunteer subjects, primary hyperparathyroid patients before and after surgery and patients with secondary hyperparathyroidism. 3. In primary and secondary hyperparathyroidism the biological activity was significantly higher than in urine from normal subjects, which was in turn significantly higher than the activity in the urine of hypoparathyroid patients. This bioactivity diminished after surgical removal of a hyperparathyroid adenoma. 4. Decreased activity after trypsinization indicated the peptidic nature of the hypercalcaemic substance.

Effect of Small Increments in Plasma Calcium Concentration on the Responsiveness of Forearm Resistance Vessels to Verapamil in Normal Subjects

1984 ◽  
Vol 67 (6) ◽  
pp. 613-618 ◽  
Author(s):  
B. F. Robinson ◽  
R. J. W. Phillips
Keyword(s):  
Calcium Concentration ◽  
Venous Blood ◽  
Normal Subjects ◽  
Plasma Calcium ◽  
Calcium Handling ◽  
Membrane Function ◽  
Resistance Vessels ◽  
Initial Control ◽  
Plasma Calcium Concentration ◽  
Small Increments

1. The effect of a small increase in local plasma calcium concentration on the responsiveness of the forearm resistance vessels to verapamil has been examined in normal subjects, by using a plethysmographic method with infusion of calcium and other agents into the brachial artery. 2. Infusion of calcium at a rate which increased the concentration in forearm venous blood by about 0.5 mmol/l caused basal blood flow to fall by 19% and the dilator response to verapamil to fall by 35% (n = 8; P<0.02). 3. When, after 46 min, the infusion of calcium was discontinued, the dilator response to verapamil increased to reach a level 53% higher than the initial control (n = 8; P<0.02). 4. Infusion of calcium had no effect on the dilator response to sodium nitroprusside. 5. Infusion of noradrenaline at a rate which caused a greater reduction in basal flow than that induced by calcium had no effect on the response to verapamil. 6. It is concluded that the dilator response to verapamil, which is thought to reflect activity of the potential operated system for calcium entry, is selectively depressed by a small elevation of plasma calcium concentration, but subsequently becomes elevated. These findings point to an important role for calcium in the regulation of membrane function in the resistance vessels and support the view that altered calcium handling may contribute to the development of primary hypertension.

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