Gender-Divergent Aetiological Factors in Obsessive-Compulsive Disorder

1991 ◽  
Vol 158 (2) ◽  
pp. 260-263 ◽  
Author(s):  
Homa F. Noshirvani ◽  
Yiannis Kasvikis ◽  
Isaac M. Marks ◽  
Fivos Tsakiris ◽  
William O. Monteiro
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Early Onset ◽  
Late Onset ◽  
Low Fertility ◽  
Onset Age ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
History Of ◽  
Low Rate

Among 307 adults with OCD, early onset (age 5–15 years) was more common in men and later onset (age 26–35 years) in women. Early onset was associated with more checking, and late onset with more washing. More women than men had a history of treated depression; 12% of the women but none of the men had a history of anorexia. More women than men were married. Gender-divergent features may reflect differential aetiological factors. Our sample resembled others in the literature in its slight overall female preponderance, low rate of marriage and low fertility, onset mainly before age 35 years, chronicity, and common present and past depression.

Admixture analysis of age at onset in obsessive–compulsive disorder

2005 ◽  
Vol 35 (2) ◽  
pp. 237-243 ◽  
Author(s):  
RICHARD DELORME ◽  
JEAN-LOUIS GOLMARD ◽  
NADIA CHABANE ◽  
BRUNO MILLET ◽  
MARIE-ODILE KREBS ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Late Onset ◽  
Age At Onset ◽  
Admixture Analysis ◽  
Obsessive Compulsive ◽  
General Anxiety Disorder ◽  
General Anxiety ◽  
Compulsive Disorder ◽  
History Of ◽  
Best Fitting

Background. Age at onset (AAO) has been useful to explore the clinical, neurobiological and genetic heterogeneity of obsessive–compulsive disorder (OCD). However, none of the various thresholds of AAO used in previous studies have been validated, and it remains an unproven notion that AAO is a marker for different subtypes of OCD. If AAO is a clinical indicator of different biological subtypes, then subgroups based on distinct AAOs should have separate normal distributions as well as different clinical characteristics.Method. Admixture analysis was used to determine the best-fitting model for the observed AAO of 161 OCD patients.Results. The observed distribution of AAO in OCD is a mixture of two Gaussian distributions with mean ages of 11·1±4·1 and 23·5±11·1 years. The first distribution, defined by early-onset OCD, had increased frequency of Tourette's syndrome and increased family history of OCD. The second distribution, defined by late-onset OCD, showed elevated prevalence of general anxiety disorder and major depressive disorder.Conclusions. These results, based on a statistically validated AAO cut-off and those of previous studies on AAO in OCD, suggest that AAO is a crucial phenotypic characteristic in understanding the genetic basis of this disorder.

Early Onset Obsessive-Compulsive Disorder With and Without Tics

CNS Spectrums ◽  
2009 ◽  
Vol 14 (7) ◽  
pp. 362-370 ◽  
Author(s):  
Maria Alice de Mathis ◽  
Juliana B. Diniz ◽  
Roseli G. Shavitt ◽  
Albina R. Torres ◽  
Ygor A. Ferrão ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Early Onset ◽  
Age Of Onset ◽  
Age At Onset ◽  
Clinical Manifestations ◽  
Tic Disorders ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Diagnostic And Statistical Manual ◽  
History Of

ABSTRACTIntroduction: Research suggests that obsessive-compulsive disorder (OCD) is not a unitary entity, but rather a highly heterogeneous condition, with complex and variable clinical manifestations.Objective: The aims of this study were to compare clinical and demographic characteristics of OCD patients with early and late age of onset of obsessive-compulsive symptoms (OCS); and to compare the same features in early onset OCD with and without tics. The independent impact of age at onset and presence of tics on comorbidity patterns was investigated.Methods: Three hundred and thirty consecutive outpatients meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for OCD were evaluated: 160 patients belonged to the “early onset” group (EOG): before 11 years of age, 75 patients hadResults: The EOG had a predominance of males, higher frequency of family history of OCS, higher mean scores on the “aggression/violence” and “miscellaneous” dimensions, and higher mean global DY-BOCS scores. Patients with EOG without tic disorders presented higher mean global DY-BOCS scores and higher mean scores in the “contamination/cleaning” dimension.Conclusion: The current results disentangle some of the clinical overlap between early onset OCD with and without tics.

Early-onset versus late-onset obsessive–compulsive disorder: an immunological comparative study

2017 ◽  
Vol 38 (1) ◽  
pp. 41 ◽  
Author(s):  
SaharEl Emam Gad ◽  
WafaaMohamed El Emshaty ◽  
HananEl-sayed Hussein ◽  
OsamaAhmed El-Boraie ◽  
MohammedAli Ezzat El-Hadid
Keyword(s):  
Comparative Study ◽  
Obsessive Compulsive Disorder ◽  
Early Onset ◽  
Late Onset ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

Gender Differences in Obsessive Compulsive Disorder

1995 ◽  
Vol 29 (1) ◽  
pp. 114-117 ◽  
Author(s):  
David J. Castle ◽  
Alicia Deale ◽  
Isaac M. Marks
Keyword(s):  
Gender Differences ◽  
Eating Disorder ◽  
Anxiety Disorders ◽  
Obsessive Compulsive Disorder ◽  
Past History ◽  
Onset Age ◽  
Obsessive Compulsive ◽  
Behavioural Treatment ◽  
Compulsive Disorder ◽  
History Of

We investigated gender differences in 219 patients with obsessive compulsive disorder consecutively referred to a centre specialising in the behavioural treatment of anxiety disorders. Females had a later mean onset-age, and were more likely to be married and to have children; they were also marginally more likely to have a past history of an eating disorder or depression, while males were more likely to have a history of anxious or meticulous personality traits. Family loading for psychiatric disorders did not differ significantly between the sexes. The results are discussed in the context of the epidemiological literature on gender differences in OCD.

N2 AND P3 POTENTIALS IN EARLY-ONSET AND LATE-ONSET PATIENTS WITH OBSESSIVE-COMPULSIVE DISORDER

2013 ◽  
Vol 31 (12) ◽  
pp. 997-1006 ◽  
Author(s):  
Yasemin Keskin-Ergen ◽  
Raşit Tükel ◽  
Banu Aslantaş-Ertekin ◽  
Erhan Ertekin ◽  
Serap Oflaz ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Early Onset ◽  
Late Onset ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) influences age at onset of obsessive–compulsive disorder

2013 ◽  
Vol 16 (9) ◽  
pp. 1951-1958 ◽  
Author(s):  
Leonhard Lennertz ◽  
Petra E. Franke ◽  
Hans Jörgen Grabe ◽  
Friederike Rampacher ◽  
Svenja Schulze-Rauschenbach ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Early Onset ◽  
Late Onset ◽  
Receptor Gene ◽  
Age At Onset ◽  
Neuropeptide S ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Brain Functions

Abstract Neuropeptide S (NPS) is a novel central acting neuropeptide that modulates several brain functions. NPS has shown strong anxiolytic-like effects and interactions with other central transmitter systems, including serotonin and glutamate. A coding variation (Asn107Ile) of the NPS receptor gene (NPSR1) was associated with panic disorder and schizophrenia. Based on these encouraging findings, the present study aimed at exploring a potential role of NPSR1 in obsessive–compulsive disorder (OCD). A sample of 232 OCD patients was successfully genotyped for the NPSR1 Asn107Ile variant (rs324981). Age at onset was taken into account to address the heterogeneity of the OCD phenotype. The NPSR1 genotype significantly affected age at onset of the OCD patients, with a mean age at onset approximately 4 yr earlier in homozygous carriers of the low-functioning Asn107 variant compared to patients with at least one Ile107 variant (p = 0.032). Case–control analyses with 308 healthy control subjects reveal a highly significant association of the Asn107 variant with early onset OCD (odds ratio = 2.36, p = 0.0004) while late onset OCD or the OCD group as a whole were unrelated to the NPSR1 genotype. Based on our association finding relating NPSR1 genotype to early onset OCD, we suggest a differential role of the NPS system in OCD. In particular, the early onset OCD subtype seems to be characterized by a genetically driven low NPS tone, which might affect other OCD-related transmitter systems, including the serotonin and glutamate systems. In agreement with preclinical research, we suggest that NPS may be a promising pharmacological candidate with anti-obsessional properties.

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