Relationship Between Iron Status and Chronic Akathisia in an In-patient Population with Chronic Schizophrenia

1992 ◽  
Vol 161 (6) ◽  
pp. 791-796 ◽  
Author(s):  
Thomas R. E. Barnes ◽  
Simon M. Halstead ◽  
Patrick W. A. Little
Keyword(s):  
Antipsychotic Medication ◽  
Patient Population ◽  
Serum Iron ◽  
Iron Status ◽  
Iron Concentration ◽  
Chronic Schizophrenia ◽  
Serum Iron Concentration ◽  
Percentage Saturation ◽  
Significant Difference ◽  
Low Serum

Iron status and akathisia were assessed in 105 long-stay in-patients who fulfilled DSM–III–R criteria for schizophrenia, all but three of whom were receiving antipsychotic medication. Chronic akathisia was diagnosed in 23% and pseudoakathisia in 20%. No significant correlation was found between serum iron concentration and the severity of akathisia. There was no significant difference in serum iron concentration between patients with chronic akathisia and those without. However, serum iron and percentage saturation were significantly raised in patients with pseudoakathisia compared with patients with chronic akathisia, and tended to be higher than in patients with akathisia. These findings do not support an association between low serum iron and chronic akathisia.

scholarly journals Serum Iron Level as a Potential Predictor of Coronavirus Disease 2019 Severity and Mortality: A Retrospective Study

2020 ◽  
Vol 7 (7) ◽  
Author(s):  
Kang Zhao ◽  
Jucun Huang ◽  
Dan Dai ◽  
Yuwei Feng ◽  
Liming Liu ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Serum Iron ◽  
Iron Status ◽  
Iron Concentration ◽  
Iron Level ◽  
Serum Iron Level ◽  
Amyloid A ◽  
Significant Difference ◽  
Before And After ◽  
Low Serum

Abstract Background Various types of pulmonary diseases are associated with iron deficiency. However, information on iron status in coronavirus disease 2019 (COVID-19) is scarce. Methods This study included 50 hospitalized patients with confirmed COVID-19. The role of serum iron in predicting severity and mortality of COVID-19 was evaluated. Results The most common symptoms of COVID-19 patients in this study were cough (82%), fever (64%), and chest distress (42%). Of the 50 patients, 45 (90%) patients had abnormally low serum iron levels (<7.8 μmol/L). The severity of COVID-19 was negatively correlated with serum iron levels before and after treatment and was positively correlated with C-reactive protein, serum amyloid A, D-dimer, lactate dehydrogenase, urea nitrogen, and myoglobin levels. Decreased serum iron level could predict the transition of COVID-19 from mild to severe and critical illness. Seven (53.8%) patients with a lower serum iron level after treatment in the critical group had died. There was a significant difference in posttreatment serum iron levels between COVID-19 survivors and nonsurvivors. Conclusions Serum iron deficiency was detected in the patients with COVID-19. The severity and mortality of the disease was closely correlated with serum iron levels. Low serum iron concentration was an independent risk factor for death in COVID-19 patients.

scholarly journals Iron Status in Pre-Eclampsia: A Case-Comparison Study

2013 ◽  
Vol 5 (2) ◽  
pp. 53-55 ◽  
Author(s):  
R Sultana ◽  
S Ahmed ◽  
N Sultana ◽  
SM Fazlul Karim
Keyword(s):  
Pregnant Women ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Iron Status ◽  
Iron Concentration ◽  
College Hospital ◽  
Ferritin Concentration ◽  
Medical College ◽  
Serum Iron Concentration ◽  
Case Comparison

Preeclampsia is one of the most leading causes of maternal mortality in developing countries. Many studies have demonstrated the relation between alteration of iron status and preeclampsia. The aim of the study was to assess the status of iron in preeclampsia. This case control study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka from July 2010 to June 2011. A total number of 100 pregnant women in the third trimester of pregnancy attending the Obstetrics & Gynaecology Department of Dhaka Medical College Hospital were selected purposively as study subjects. Among them 50 diagnosed cases of preeclampsia were selected as cases and 50 normal healthy pregnant women as controls. Serum ferritin and serum iron concentration were measured in all study subjects. The mean serum ferritin concentration in cases and controls were 95.06±50.07 ?g/l and 45.56±27.44 ?g/l respectively. Mean serum iron concentration in cases was 121.78±41.93 ?g/dl and that in controls was 61.04±24.18 ?g/dl. The present study showed significant differences of mean serum ferritin and serum iron between cases and controls. The study revealed presence of significantly higher level of serum ferritin and serum iron in preeclamptic group. DOI: http://dx.doi.org/10.3329/bjmb.v5i2.13345 Bangladesh J Med Biochem 2012; 5(2): 53-55

Effect of Phenylhydrazine and Bone Marrow Inhibitors on Red Cell Destruction and Serum Iron Concentration

1958 ◽  
Vol 193 (1) ◽  
pp. 92-94
Author(s):  
Alfred Chanutin
Keyword(s):  
Bone Marrow ◽  
Serum Iron ◽  
Iron Concentration ◽  
Hemoglobin Concentration ◽  
Moderate Increase ◽  
Serum Iron Concentration ◽  
Moderate Anemia ◽  
Sublethal Doses ◽  
Slight Depression ◽  
Marrow Activity

The administration of sublethal doses of bone marrow depressants (nitrogen mustard, triethylene melamine and thioguanine) causes a temporary, moderate increase in serum iron concentration, a slight depression of bone marrow activity and no change in hemoglobin concentration. A combination of any of these drugs with a small dose of phenylhydrazine causes a temporary marked hyperferremia, a moderate anemia and a marked reticulocytosis. The results indicate that hyperferremia is not necessarily associated with bone marrow activity.

Iron Absorption after Single Pharmacological Oral Iron Loading Test in Patients on Chronic Peritoneal Dialysis and in Healthy Volunteers

2000 ◽  
Vol 20 (6) ◽  
pp. 662-666 ◽  
Author(s):  
Bahar Bastani ◽  
Shah Islam ◽  
Nasser Boroujerdi
Keyword(s):  
Serum Iron ◽  
Iron Absorption ◽  
Iron Concentration ◽  
Significant Rise ◽  
Oral Iron ◽  
Iron Sulfate ◽  
Chronic Peritoneal Dialysis ◽  
Dialysis Patients ◽  
Control Subjects ◽  
Serum Iron Concentration

Objective Oral iron is poorly absorbed in chronic dialysis patients. We tested the hypothesis that a superpharmacologic dose of iron sulfate (260 mg elemental iron) administered on an empty stomach results in significant iron absorption in these patients. Design A prospective open controlled trial. Setting Outpatient department of a university hospital. Patients Nine stable chronic peritoneal dialysis (PD) patients and seven normal control subjects. Method All subjects ingested a single dose of 4 tablets of iron sulfate (260 mg elemental iron total) in the morning while fasting. Outcome Measures Serum iron concentrations at baseline, and at 2 and 4 hours after the oral dose were compared between the two groups. Results The control group showed a significant rise in mean [± standard error (SE)] serum iron concentration, from a baseline value of 76.5 ± 7 μg/dL to 191 ± 10.5 μg/dL at 2 hours and to 190 ± 24 μg/dL at 4 hours. This result represents a percentage rise of 164% ± 32% at 2 hours and 152% ± 28.5% at 4 hours. In the PD patients, a significant rise in serum iron concentration was also seen, from a baseline value of 64 ± 8 μg/dL to 130 ± 3 μg/dL at 2 hours and 111 ± 18 μg/dL at 4 hours. This result represents a percentage rise of 105% ± 29% at 2 hours and 77% ± 23.5% at 4 hours. However, the absolute change in serum iron concentration in PD patients at 2 and 4 hours was approximately equal to 50% of the change in control subjects at those time points. None of the PD patients experienced gastrointestinal side effects; 4 control subjects experienced mild side effects. Conclusion Despite impaired oral iron absorption in chronic dialysis patients, a large pharmacologic dose given orally can result in significant iron absorption and may prove to be a more efficient means of oral iron supplementation therapy in these patients.

scholarly journals The iron content in organs of free ranging European bison from the Białowieża herd / Zawartość żelaza w tkankach żubra ze stada białowieskiego

2013 ◽  
Vol 13 (2) ◽  
pp. 357-364 ◽  
Author(s):  
Tadeusz Kośla ◽  
Michał Skibniewski ◽  
Ewa Skibniewska ◽  
Grażyna Urbańska-Słomka
Keyword(s):  
Iron Content ◽  
Dry Matter ◽  
Iron Status ◽  
Iron Concentration ◽  
European Bison ◽  
Fresh Tissue ◽  
Significant Difference ◽  
Males And Females ◽  
Free Ranging ◽  
Białowieża Primeval Forest

Abstract The aim of the study was to determine iron status in chosen organs of the European bison free ranging in Białowieża Primeval Forest. The material for analyses was obtained from animals eliminated during annual selection. Segments of liver, kidney, muscle, rib, and hoof were collected. Animals were divided depending on gender (males and females) and age (calves up to 1 year and animals older than 2 years). Mean iron concentration in liver was 263.59 mg ∙ kg-1 fresh tissue. The iron content was significantly higher in the group of animals older than 2 years (P≤0.05). The average content of iron in kidneys amounted to 156.70 mg ∙ kg-1 fresh tissue. The average iron content in muscles amounted to 79.95 mg ∙ kg-1 fresh tissue. Similarly to the liver samples a statistically significant difference (P≤0.05) was demonstrated depending on age. The average iron content in ribs and in the horn of the hoof wall of all European bison amounted to 38.90 mg ∙ kg-1 fresh tissue and 47.87 mg ∙ kg-1 dry matter, respectively. No statistically significant differences in the iron content were observed depending on gender.

scholarly journals Studies in Iron Absorption IV. Effect of Humoral Factors on Iron Absorption

Blood ◽  
1969 ◽  
Vol 34 (4) ◽  
pp. 488-495 ◽  
Author(s):  
S. HÖGLUND ◽  
P. REIZENSTEIN
Keyword(s):  
Serum Iron ◽  
Plasma Clearance ◽  
Iron Absorption ◽  
Iron Concentration ◽  
Normal Serum ◽  
Humoral Factors ◽  
Parenteral Treatment ◽  
Essentially Normal ◽  
Significant Difference ◽  
The Mean

Abstract 1. In a group of blood donors the mean serum iron concentration, and plasma clearance of iron did not differ significantly from normal means whereas the mean TIBC was increased. No statistically significant correlation existed between these values and the amount of blood donated in the year preceding the study. 2. The iron absorption was significantly correlated with the amount of blood donated during the year preceding the study, and the mean absorption value was significantly higher than in normal controls. 3. Compared to healthy men higher absorption values were likewise found in a group of healthy young women, without pathologic menstruations, and with essentially normal serum iron and TIBC values. 4. In order to discover how the intestine is instructed to increase iron absorption the correlations were studied between iron absorption and hemoglobin, serum iron, TIBC and plasma clearance of iron. No significant correlations were found. It is suggested that absorption is not primarily regulated by these factors. The finding of increased absorption in persons with essentially normal serum iron, TIBC and iron clearance supports this suggestion. 5. To determine whether the high absorption observed in women was a sign of iron deficiency, absorption was again studied after combined oral and parenteral iron treatment. It decreased in each case, except one where absorption remained unchanged. 6. Parenteral treatment alone, increased the serum iron but no statistically significant difference was found in TIBC, plasma clearance of iron, or iron absorption. Absorption after parenteral treatment was correlated mainly with pretreatment absorption. 7. After oral treatment on the other hand, absorption decreased significantly. No substantial changes were noted in serum iron or plasma clearance of iron, while TIBC unexpectedly increased. The findings support the view that no change in serum iron, TIBC or the plasma iron clearance is required to bring about a decrease in iron absorption.

Serum Iron Determinations

1958 ◽  
Vol 4 (4) ◽  
pp. 290-295 ◽  
Author(s):  
Harold L Rosenthal ◽  
Mari Lou Pfluke ◽  
Lois Jud
Keyword(s):  
Serum Iron ◽  
Iron Concentration ◽  
Serum Samples ◽  
Serum Iron Concentration ◽  
Control Serum ◽  
Control Samples

Abstract The inclusion of control serum samples for the estimation of serum iron by the Kingsley-Getchell bathophenanthroline and the Ramsay dipyridyl methods is necessary in order to correct for nonspecific absorption of serum pigments. In the absence of control samples, serum iron concentration may be from 25 to 90 per cent too high.

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