scholarly journals Serum Iron Level as a Potential Predictor of Coronavirus Disease 2019 Severity and Mortality: A Retrospective Study

2020 ◽  
Vol 7 (7) ◽  
Author(s):  
Kang Zhao ◽  
Jucun Huang ◽  
Dan Dai ◽  
Yuwei Feng ◽  
Liming Liu ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Serum Iron ◽  
Iron Status ◽  
Iron Concentration ◽  
Iron Level ◽  
Serum Iron Level ◽  
Amyloid A ◽  
Significant Difference ◽  
Before And After ◽  
Low Serum

Abstract Background Various types of pulmonary diseases are associated with iron deficiency. However, information on iron status in coronavirus disease 2019 (COVID-19) is scarce. Methods This study included 50 hospitalized patients with confirmed COVID-19. The role of serum iron in predicting severity and mortality of COVID-19 was evaluated. Results The most common symptoms of COVID-19 patients in this study were cough (82%), fever (64%), and chest distress (42%). Of the 50 patients, 45 (90%) patients had abnormally low serum iron levels (<7.8 μmol/L). The severity of COVID-19 was negatively correlated with serum iron levels before and after treatment and was positively correlated with C-reactive protein, serum amyloid A, D-dimer, lactate dehydrogenase, urea nitrogen, and myoglobin levels. Decreased serum iron level could predict the transition of COVID-19 from mild to severe and critical illness. Seven (53.8%) patients with a lower serum iron level after treatment in the critical group had died. There was a significant difference in posttreatment serum iron levels between COVID-19 survivors and nonsurvivors. Conclusions Serum iron deficiency was detected in the patients with COVID-19. The severity and mortality of the disease was closely correlated with serum iron levels. Low serum iron concentration was an independent risk factor for death in COVID-19 patients.

scholarly journals ROLE OF SERUM IRON AND ITS ASSOCIATION WITH ANEMIC PREVALANCE AMONG PATIENTS WITH DIFFERENT TYPE OF CANCER

2017 ◽  
Vol 5 (5(SE)) ◽  
pp. 37-41
Author(s):  
Andrew Pradeep M ◽  
Indira G ◽  
Sethu Nagarajan R
Keyword(s):  
Iron Deficiency ◽  
Serum Iron ◽  
Physiological Activity ◽  
Iron Concentration ◽  
Active Role ◽  
Control Individual ◽  
Iron Level ◽  
Serum Iron Level ◽  
Immune Effector ◽  
Patients With Cancer

Cancer is a group of diseases in which cells are aggressive, invasive and sometimes metastatic. Nutritional status an important factor that contributes to immune competence for which trace minerals plays a crucial role in the biochemical and physiological activity of the system. Trace element a category of minerals essential for the biological system and plays an active role in immune effector mechanism.  Normal range of iron essential for body metabolism, iron deficiencies leads to anemia which might complicate the event of tumor genesis. Study involved 50 volunteers (36 females, 14 males) of cancer patients of Mohan Nursing Home Madurai. Serum was collected in the informed consent of the patients. Serum iron level was quantified using Atomic Absorption Spectrophotometer. Study documented percentage deviation of serum iron concentration (85%) with severe anemic prevalence from the control individual (without cancer) and also establish an association of iron deficiency with anemic prevalence. Study documented the existence of Iron deficiency which is the most common cause of anemia worldwide. Iron plays a role in oxygen transfer in cytochromes, protein molecules involved in the production of energy in cells and also exhibit certain properties to facilitate antitumor status. Study concludes that serum iron modulations need to be emphasized to minimize the burdenization of the host with Clinical associated complications of Iron deficiency among patients with cancer.

scholarly journals Determination of Level of Serum Iron among Routine Iron Supplemented Pregnant Women Attending Private Clinic in Sulaimani City, Kurdistan-Iraq

2021 ◽  
Vol 11 (1) ◽  
pp. 76-79
Author(s):  
Sardar M. Weli ◽  
Osama H. Shareef ◽  
Syamand A. Qadir
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Serum Iron ◽  
Age Groups ◽  
First Trimester ◽  
Private Clinic ◽  
Iron Level ◽  
Serum Iron Level ◽  
Significant Difference ◽  
Questionnaire Form

Iron deficiency, with or without anemia, is common in pregnant women and more than half of the anemia’s in the world are due to the deficiency of iron in the serum. The aims of this study were to determine the percentage and level of serum iron among iron supplemented pregnant women in different trimesters and in different age groups among supplemented pregnant women in Sulaimani city. This study was carried out in the private clinic in the Sulaimani city-Kurdistan Region of Iraq. The pregnant women were participated and enrolled between the first of December 2018 and first of December 2019. Two hundred and seventy-five healthy and iron supplemented pregnant women were selected randomly and the questionnaire form, which contains information about age of mothers and their gestational age, was filled and serum iron level was measured by COBAS C111 analyzer. The results of this study found that the percentage of iron deficiency among participants was high 33%, 45%, and 52.6 % in the first trimester in different age groups <25, 25–35, and above 35 years old, respectively. However, in the third trimesters decreased to 12.5%, 7.1%, and 3.7% in <25, 25–35, and above 35 years old, respectively. Regarding serum iron levels, the present study found that there were significant differences between ages 25 and 35 with age <25 years. However, there was no significant difference between first, second, and third trimesters. This study concludes that the percentage of iron deficiency among supplemented pregnant women was high compared to other cities or other countries. Pregnant women who their ages <25 are at risk of serum iron deficiency. On the other hand, pregnancy trimesters had no effects on the serum iron level among supplemented pregnant women.

scholarly journals LOW SERUM IRON LEVEL AND LYMPHOCYTE DNA DAMAGE AMONG ADULTS

2012 ◽  
Vol 02 (02) ◽  
pp. 30-35
Author(s):  
Pinak Samal ◽  
Suchetha Kumari N. ◽  
Indira R. Samal ◽  
Kathyayani Sathish
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Iron Deficiency ◽  
Comet Assay ◽  
Serum Iron ◽  
Iron Level ◽  
Alkaline Comet Assay ◽  
Serum Iron Level ◽  
The World ◽  
Low Serum

AbstractCellular DNA damage has been related to both external and internal factors. Serum Iron is one of the factors which has importance in the oxidative status of the cell. Higher iron levels have been found to be associated with imbalance in the oxidation-antioxidant system and has been associated with DNA damage due to oxidative stress. However, oxidative stress and DNA damage has also been reported in iron deficiency states, in some studies. It appears that the body iron level should be maintained at optimum level for a balanced scenario and both iron excess as well as iron deficiency states may be associated with oxidative stress and attendant DNA damage. In this study, the blood collected from eighty four volunteers (fifty six males and twenty eight females) was subjected to estimation of serum iron (Bathophenanthroline method). Also, Lymphocyte DNA damage was ascertained by Alkaline Comet Assay method (Qualitative assessment only). The range of serum iron in this group was found to be between 39.91 μgm/dl – 93.55 μgm/dl in females and between 37.7 μgm/dl – 133.63 μgm/dl in males. Very high as well as very low serum iron was not found in this study group as the volunteers were all ambulatory and asymptomatic. Among the volunteers who had serum iron less than 50 μgm/dl(N=17), eleven (64.7%) had evidence of DNA damage as per the alkaline comet assay. Among the group having serum iron 51-70 μgm/dl (N=34), fourteen (41%), had evidence of DNA damage. Similarly, among the group, having serum iron 71-90 μgm/dl (N=27), evidence of DNA damage was seen in ten (37%) persons. There were very few persons with serum iron more than 91 μgm/dl (N= 6) and out of them two had evidence of DNA damage. In total, out of 84 persons, thirty seven (44%) had evidence of DNA damage as per alkaline comet assay. This trend of inverse dose response relationship was also noticed separately among males as well as in females. This is a preliminary exploratory study in India (although a few similar reports also exist in studies done in other parts of the world) and admittedly, had not taken into account of other confounding factors. Nevertheless, the findings suggesting association of low serum iron level and DNA damage, which has also been reported in some earlier studies at other parts of the world, need further examination through larger controlled studies.

Relationship Between Iron Status and Chronic Akathisia in an In-patient Population with Chronic Schizophrenia

1992 ◽  
Vol 161 (6) ◽  
pp. 791-796 ◽  
Author(s):  
Thomas R. E. Barnes ◽  
Simon M. Halstead ◽  
Patrick W. A. Little
Keyword(s):  
Antipsychotic Medication ◽  
Patient Population ◽  
Serum Iron ◽  
Iron Status ◽  
Iron Concentration ◽  
Chronic Schizophrenia ◽  
Serum Iron Concentration ◽  
Percentage Saturation ◽  
Significant Difference ◽  
Low Serum

Iron status and akathisia were assessed in 105 long-stay in-patients who fulfilled DSM–III–R criteria for schizophrenia, all but three of whom were receiving antipsychotic medication. Chronic akathisia was diagnosed in 23% and pseudoakathisia in 20%. No significant correlation was found between serum iron concentration and the severity of akathisia. There was no significant difference in serum iron concentration between patients with chronic akathisia and those without. However, serum iron and percentage saturation were significantly raised in patients with pseudoakathisia compared with patients with chronic akathisia, and tended to be higher than in patients with akathisia. These findings do not support an association between low serum iron and chronic akathisia.

scholarly journals Association between BMI and Iron Status among Diabetic Patients in Oujda-ANGAD-MOROCCO

2020 ◽  
pp. 416-423
Author(s):  
Asmae Hsaini ◽  
Youssef Aboussaleh ◽  
Samir Bikri ◽  
Ahmed Ahami
Keyword(s):  
Iron Deficiency ◽  
Serum Iron ◽  
Iron Status ◽  
Overweight And Obesity ◽  
Health Concern ◽  
Diabetic Patients ◽  
Iron Level ◽  
Serum Iron Level ◽  
Ferritin Concentration ◽  
The Mean

Nowadays, Public health concern on obesity and anemia has become very important disease in the world. Objective: In this study, we aim to examine the relationship between the overweight of diabetic patients from the Oujda-Angad region and their body iron status. Methods: A total of 114 patients aged between 18 and 70 years old. The patients were from the regional referral Center of Oujda-Angad. All patients had type 2 diabetes. They attended the centre between December the 1st, 2016 and May the 30th, 2018 and were diagnosed previously for more than 6 months. The patients were participated in this study after they have provided a written consent. Demographic and biochemical data were collected. Results: The mean ferritin concentration was between 19.14 µg /mL± and 21.32 µg / mL± and the mean Serum iron level was around 105.05µg/dl. Moreover, 34.5% of diabetic patients were overweight according to WHO Standars (BMI ≥ 25 kg/m2) while around 31% of were obese (BMI ≥ 30 kg/m2). The correlation coefficient of linear regression was positive for BMI/Plasma Ferritin and negative for BMI/hemoglobin, and BMI/Serum iron. Furthermore, the CRP concentration was less than 6mg/l for 90% of obese and overweight patients. As conclusion, we can confirm that patients having an iron deficiency are not overweight or obese. Furthermore, overweight and obesity could be a risk factor of iron deficiency in diabetic patients.

scholarly journals Iron deficiency anemia: current strategies for the diagnosis and management

2013 ◽  
Vol 4 (3) ◽  
pp. 193-202 ◽  
Author(s):  
Zühre Kaya
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Binding Capacity ◽  
Ferritin Level ◽  
Nutritional Deficiencies ◽  
Deficiency Anemia ◽  
Iron Level ◽  
Serum Iron Level ◽  
Diagnosis And Management ◽  
Low Serum

Iron deficiency is one of the commonest nutritional deficiencies in the world. It is multifactorial and may be caused by lack of intake, blood loss and intestinal causes. Clinical features are highly variable, and most patients are asymptomatic. Typical laboratory features of iron deficiency anemia (IDA) include a hypochromic microcytic anemia, low serum iron level, high total iron binding capacity, low serum ferritin level. Usefulness of monitoring serum transferrin receptor level (sTfR) and hepcidin for identifying IDA have been examined in a few studies. Available data suggest that sTfR can potentially become a valuable tool for regular testing of patients in the future. Despite IDA is easily corrected with iron therapy, establishing the cause can be difficult, particularly in cases caused by disorders of iron transport. Education for clinician needs to focus on increasing awareness of the importance of failure respond to iron supplementation. The aim of this review was to outline the current strategies for the diagnosis and management of IDA in the light of the latest reports.

scholarly journals Iron Status in Malnourished Children : A Cross Sectional Study

2014 ◽  
Vol 13 (3) ◽  
pp. 50-53
Author(s):  
Shormin Ara Ferdousi ◽  
Rajat Sanker Roy Biswas ◽  
Nayan Kanti Paul ◽  
Mohammed Rezaul Karim
Keyword(s):  
Serum Iron ◽  
Iron Status ◽  
Transferrin Saturation ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Iron Level ◽  
Serum Iron Level ◽  
Cross Sectional ◽  
Malnourished Children ◽  
Different Types

Objectives: Malnutrition is a common condition among children and iron status varies in different types of malnutrition. So the present study is aimed to find the different iron status among severe malnourished children in our context. Methods: A hospital based cross sectional study was done in the Paediatrics ward Chittagong Medical College Hospital in a period of 6 months from January to July 2013 among the 50 cases of malnourished children of age range between 1 to 5 years and Weight for Height Z score(WHZ) was <-2  SD. Sampling technique was continuous purposive sampling. Venous blood was collected to assay the different iron profile mainly serum iron level, total iron binding capacity(TIBC) and transferrin saturation(TSAT). Data was analyzed after correction by SPSS-19. Results: Among the 50 study children of different age groups 15 patients were 1 to 2 years, 18 patients were 2 to 3 years, 10 patients were 3 to 4 years and 7 patients were at 4-5 years of age groups. Among the patients, 29 (58%) of patients were female and 21(42%) of the patients were male. Most of the children were from the families of low socioeconomic status 38(76%). 2(4%) children were from upper middle class who had step mother. Among the selected patients the dominating clinical features were anemia was found among 45(90%) of patients which was mild(66.6%), moderate(26.6%) and severe(6.6%). Skin changes(32%), eye  changes (10%) and hair changes(48%) were also found. Among the 50 study subjects prelacteal feeding was given among 43(86%) children, breast feeding was given 45(90%), exclusive breast feeding was given to 24(48%) of children and complementary feeding after 6 months was given to 29(58%) patients. Among the 50 patients -2 to -3 SD weight for height was found in 20(40%) patients and <-3 SD was found in 30(60%) patients. Most of the children was found to have Mid Upper Arm Circumference (MUAC) 115-125 mm(50%). Iron status was measured among all patients where serum iron level was found 77.72 ± 11.22 mcgm/dl, TIBC was found 340.07 ± 22.67 mcgm/dl and transferrin saturation was found 22.38 ± 2.9 %. Iron status were measured among the different types of malnutrition where serum iron level and transferrin saturation was high among all patients with malnutrition while TIBC was lower than standard level in all patients. Different biochemical status were measured among the different types of malnutrition where serum total protein, serum albumin, Hb% were lower than standard level in all patients.Conclusion: Change in different iron status is a common findings in malnourished children. Screening of all children for anemia and providing iron and folic acid (IFA) or multiple micronutrients (MMN) supplements to children and Infant and Young Child Feeding (IYCF) should be addressed at all level to overcome the situation.DOI: http://dx.doi.org/10.3329/cmoshmcj.v13i3.21024

Association of serum iron and response to immune checkpoint inhibitors (ICIs) in metastatic clear cell renal cell carcinoma (mccRCC).

2020 ◽  
Vol 38 (6_suppl) ◽  
pp. 723-723
Author(s):  
Nityam Rathi ◽  
David D. Stenehjem ◽  
Neeraj Agarwal ◽  
Andrew W Hahn ◽  
Deepika Sirohi ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Serum Iron ◽  
Clear Cell ◽  
Checkpoint Inhibitors ◽  
Transferrin Saturation ◽  
Iron Level ◽  
Eligibility Criteria ◽  
Cell Renal Cell Carcinoma ◽  
Serum Iron Level ◽  
Iron Profile

723 Background: ICIs have improved survival in mRCC patients (pts), yet response rates (RR) to these treatments are variable. Biomarkers predictive of response to ICIs may improve outcomes for mccRCC pts. Genes that promote tumor-specific iron accumulation such as hepcidin (HAMP) or transferrin (TF) are significantly correlated with decreased overall survival in clear cell RCC (TCGA-KIRC). Iron deficiency in cancer patients is positively correlated with tumor stage and inversely proportional to treatment response (PMID: 23567147). Here, we investigate whether serum iron profile may be associated with response to ICIs in mccRCC pts. Methods: Clinical data was obtained from an mRCC registry at the Huntsman Cancer Institute, University of Utah. Analyses were limited to mccRCC pts who had serum iron studies within 6 months before initiating an ICI and had been assessed for RR. ICIs included nivolumab + ipilimumab, atezolizumab, or nivolumab alone. Responses were defined as complete response (CR), partial response (PR), stable disease (SD), or progressive disease (PD) by RECIST criteria. Clinical benefit (CB) was defined as CR + PR + SD. Descriptive statistics were used to assess associations between iron stores and response to ICIs and IMDC criteria. Results: 36 pts met all aforementioned eligibility criteria (29 were of IMDC intermediate risk, 7 were of IMDC poor risk). 5 pts received a first-line ICI, and the remaining 31 pts received ICIs as salvage therapy. Pts with CB had a significantly higher median serum iron level compared to those with no CB (59 vs 38.5 ug/dL; p=0.024). Furthermore, pts with normal transferrin saturation (TSAT %) were more likely to derive CB from ICIs (p=0.048). No association was found between serum ferritin (a marker of inflammation and tissue iron) and response to ICIs. Conclusions: In this hypothesis-generating study, increased serum iron, and TSAT levels within the normal range are associated with an increased likelihood of response to ICIs in pts with mccRCC. Once validated, these results may establish serum iron profile as a predictive marker of response to ICIs, in addition to providing the rationale for ruling out iron deficiency before starting ICIs.

scholarly journals Association between iron deficiency anaemia and simple febrile seizure in South Indian rural population

2020 ◽  
Vol 7 (12) ◽  
pp. 2355
Author(s):  
Gayathri Durai ◽  
Syamily Parambath ◽  
Rajendiran Ramachari Ramayi
Keyword(s):  
Risk Factor ◽  
Iron Deficiency ◽  
Febrile Seizure ◽  
Serum Iron ◽  
Iron Deficiency Anaemia ◽  
Febrile Seizures ◽  
Iron Level ◽  
Serum Iron Level ◽  
Deficiency Anaemia ◽  
South Indian

Background: Simple febrile seizure is a common problem worldwide, many studies have investigated the etiology and natural history of febrile seizures and evaluated various management strategies, but very little information is available about iron deficiency as a risk factor. Hence, we aimed to determine the association between iron deficiency anaemia and simple febrile seizures in south Indian rural population. Methods: It is an observational study done in paediatrics department at Sri Venkateshwaraa medical college hospital and research centre. A total 120 (60 cases and 60 control) were included in the study. Children with febrile seizures and controls were included fever without seizures. Informed consent was taken from parents of each child. Children were divided into two groups, cases and controls. Serum ferritin level, Hb, HCT and MCV levels were assessed.Results: Mean Hb level in cases and controls were 9.1±1.2 and 12.7±1.7 mg/dl respectively. Mean MCV value in cases and controls was 78.1±6.2 and 81.4±6.9 respectively. Mean serum iron level in cases was 29.9±4.9 and in controls mean serum iron level was 42.8±7.4. Conclusions: Iron deficiency anaemia is considered as a risk factor for febrile seizures in children.

scholarly journals Role of vitamin D, serum zinc, and serum iron deficiency in community-acquired pneumonia in children

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Asmaa Alhusseiny Ahmed Alsharkawy ◽  
Ahmed R. Rezk
Keyword(s):  
Vitamin D ◽  
Serum Iron ◽  
Serum Zinc ◽  
Community Acquired Pneumonia ◽  
Control Group ◽  
Iron Level ◽  
Healthy Children ◽  
Serum Iron Level ◽  
Vitamin D Levels ◽  
Significant Difference

Abstract Background Community-acquired pneumonia is a major cause of death among children. Inadequate nutrition disrupts the immune system and increases the susceptibility to infections. We aimed to evaluate the association between vitamin D, serum zinc, and iron, and pneumonia. A case-control study was conducted at the outpatient clinic and emergency room of Children’s Hospital. Thirty-one patients with community-acquired pneumonia and 36 healthy children (control group) underwent serum sampling for vitamin D, zinc, and iron. Results Most patients had mild form (n = 17, 54.8%). All patients survived and were discharged. The serum iron level showed a non-significant difference between pneumonia and control groups (p ˃ 0.05). TIBC, vitamin D, and serum zinc were significantly lower in the patient group than the control group (P value = 0.04, < 0.001, and 0.03, respectively). Vitamin D deficiency was highly associated with the severity of pneumonia (P value = 0.008). Conclusion Adequate serum zinc and vitamin D levels may be protective against infection with community-acquired pneumonia in children aged from 2 months to 5 years old, but not iron.

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