First-episode schizophrenia

1998 ◽  
Vol 172 (S33) ◽  
pp. 77-83 ◽  
Author(s):  
Richard Jed Wyatt ◽  
L. Michelle Damiani ◽  
Ioline D. Henter
Keyword(s):  
Early Intervention ◽  
Response To Treatment ◽  
First Episode ◽  
Antipsychotic Medications ◽  
First Episode Schizophrenia ◽  
First Episode Of Schizophrenia

BackgroundThe concept that early intervention with antipsychotic medications improves the long-term course of schizophrenia is discussed.MethodThis report reviews the literature concerning early intervention with antipsychotic medications for people with firstepisodes, and how it affects long-term morbidity. It also studies the effects of discontinuing antipsychotic medications on relapse for people with first episodes.ResultsEarly intervention with antipsychotic medications appears to decrease the long-term morbidity of schizophrenia.ConclusionsEarly intervention with antipsychotic medications should be encouraged for people experiencing their first episode of schizophrenia. This report proposes that studying the various phases of subject response to treatment can be helpful in elucidating when antipsychotic medications should be tapered or withdrawn.

Ten-year employment patterns of patients with first-episode schizophrenia-spectrum disorders: comparison of early intervention and standard care services

2019 ◽  
Vol 217 (3) ◽  
pp. 491-497 ◽  
Author(s):  
Sherry Kit Wa Chan ◽  
Herbert H. Pang ◽  
Kang K. Yan ◽  
Christy Lai Ming Hui ◽  
Yi Nam Suen ◽  
...  
Keyword(s):  
Early Intervention ◽  
Standard Care ◽  
First Episode ◽  
Early Intervention Services ◽  
Employment Trajectories ◽  
Schizophrenia Spectrum ◽  
Intervention Service ◽  
Intervention Services ◽  
First Episode Schizophrenia

BackgroundLittle is known about long-term employment outcomes for patients with first-episode schizophrenia-spectrum (FES) disorders who received early intervention services.AimsWe compared the 10-year employment trajectory of patients with FES who received early intervention services with those who received standard care. Factors differentiating the employment trajectories were explored.MethodPatients with FES (N= 145) who received early intervention services in Hong Kong between 1 July 2001 and 30 June 2002 were matched with those who entered standard care 1 year previously. We used hierarchical clustering analysis to explore the 10-year employment clusters for both groups. We used the mixed model test to compare cluster memberships and piecewise regression analysis to compare the employment trajectories of the two groups.ResultsThere were significantly more patients who received the early intervention service in the good employment cluster (early intervention:N= 98 [67.6%]; standard care:N= 76 [52.4%];P= 0.009). In the poor employment cluster, there was a significant difference in the longitudinal pattern between early intervention and standard care for years 1–5 (P< 0.0001). The number of relapses during the first 3 years, months of full-time employment during the first year and years of education were significant in differentiating the clusters of the early intervention group.ConclusionsResults suggest there was an overall long-term benefit of early intervention services on employment. However, the benefit was not sustained for all patients. Personalisation of the duration of the early intervention service with a focus on relapse prevention and early vocational reintegration should be considered for service enhancement.

A Comparison of Long-Term Outcome in First-Episode Schizophrenia Following Treatment With Risperidone or a Typical Antipsychotic

2001 ◽  
Vol 62 (3) ◽  
pp. 179-184 ◽  
Author(s):  
Ashok K. Malla ◽  
Ross M. G. Norman ◽  
Derek J. Scholten ◽  
Sandra Zirul ◽  
Vinod Kotteda
Keyword(s):  
First Episode ◽  
Typical Antipsychotic ◽  
Term Outcome ◽  
Long Term Outcome ◽  
First Episode Schizophrenia

scholarly journals Normal categorical perception to syllable-like stimuli in long term and in first episode schizophrenia

2019 ◽  
Vol 208 ◽  
pp. 124-132
Author(s):  
Sarah M. Haigh ◽  
Rebecca M. Laher ◽  
Timothy K. Murphy ◽  
Brian A. Coffman ◽  
Kayla L. Ward ◽  
...  
Keyword(s):  
Categorical Perception ◽  
First Episode ◽  
First Episode Schizophrenia

First episode schizophrenia in general practice: a national survey

2006 ◽  
Vol 23 (1) ◽  
pp. 6-9 ◽  
Author(s):  
Blanaid Gavin ◽  
Walter Cullen ◽  
Brian O'Donoghue ◽  
Juan Carlos Ascencio-Lane ◽  
Gerard Bury ◽  
...  
Keyword(s):  
General Practice ◽  
General Practitioners ◽  
Postal Survey ◽  
Psychiatric Services ◽  
First Episode ◽  
Cross Sectional ◽  
Intervention Service ◽  
Almost All ◽  
First Episode Schizophrenia ◽  
First Episode Of Schizophrenia

AbstractObjective: We sought to establish the views of general practitioners about detecting and managing patients with a first episode of schizophrenia in Ireland.Method: Twenty per cent of GPs were invited to participate in a cross-sectional postal survey.Results: Sixty-two per cent (n = 261) participated. Almost all (99.2%) see at least one case of suspected first episode schizophrenia annually. The most commonly (80.7%) encountered symptom is ‘bizarre behaviour’. Many (47.7%) rarely or never prescribe antipsychotics to patients whom they suspect have a first episode of schizophrenia. However, 80.6% of GPs reported that they ‘always’ refer this group of patients to psychiatric services. Over half (57.8%) advised patients with schizophrenia to continue medication for less than a year. A large number of respondents reported that it is difficult to obtain a rapid psychiatric assessment.Conclusions: GPs want more information about identifying early psychosis, a closer liaison with psychiatric services and a rapid intervention service.

Obstetric complications predict treatment response in first-episode schizophrenia

1999 ◽  
Vol 29 (3) ◽  
pp. 621-627 ◽  
Author(s):  
J. M. J. ALVIR ◽  
M. G. WOERNER ◽  
H. GUNDUZ ◽  
G. DEGREEF ◽  
J. A. LIEBERMAN
Keyword(s):  
Treatment Response ◽  
Proportional Hazards ◽  
Poor Response ◽  
Cox Proportional Hazards ◽  
Small Sample ◽  
Obstetric Complications ◽  
Response To Treatment ◽  
First Episode ◽  
Ventricle Volume ◽  
First Episode Of Schizophrenia

Background. Understanding the role of obstetric complications (OCs) in schizophrenia could potentially shed light on the heterogeneity in the aetiology and course of schizophrenia. Many investigators have reported an association between OCs and schizophrenia, but few have examined the association between OCs and treatment outcome. We investigated this question in a sample of patients studied during their first episode of schizophrenia, schizoaffective or schizophreniform disorder.Method. OC histories were obtained for 59 patients participating in the Hillside First Episode Study. Cox proportional hazards regression analysis was used to estimate the effect of OCs on treatment response during the first episode of schizophrenia.Results. Twelve of the 59 patients (20%) had positive histories of OCs. This group exhibited lower rates of treatment response than those with negative OC histories (hazard ratio controlling for sex = 0·28; 95% CI = 0·13, 0·62). The positive OC group also had significantly greater lateral ventricle volume, baseline disorganization and number of live births. The effect of OC history on treatment response held when these three variables were controlled for.Conclusion. A history of obstetric complications predicted poor response to treatment in the first episode of schizophrenia. This large effect was based on a small sample of 59 patients. Thus, replication is called for.

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