A History of Childhood Trauma and Response to Treatment With Antipsychotics in First-Episode Schizophrenia Patients

2016 ◽  
Vol 204 (10) ◽  
pp. 787-792 ◽  
Author(s):  
Błażej Misiak ◽  
Dorota Frydecka
Keyword(s):  
Childhood Trauma ◽  
Response To Treatment ◽  
First Episode ◽  
History Of Childhood ◽  
History Of ◽  
First Episode Schizophrenia

The history of childhood trauma among individuals with ultra high risk for psychosis is as common as among patients with first-episode schizophrenia

2013 ◽  
Vol 7 (4) ◽  
pp. 414-420 ◽  
Author(s):  
Seda Şahin ◽  
Çağrı Yüksel ◽  
Julide Güler ◽  
Gülşah Karadayı ◽  
Elçin Akturan ◽  
...  
Keyword(s):  
High Risk ◽  
Childhood Trauma ◽  
First Episode ◽  
History Of Childhood ◽  
Ultra High Risk ◽  
History Of ◽  
First Episode Schizophrenia

The relationship of childhood trauma and DNA methylation of NMDA receptor genes in first-episode schizophrenia

Epigenomics ◽  
2021 ◽  
Author(s):  
Camila M Loureiro ◽  
Helene A Fachim ◽  
Fabiana Corsi-Zuelli ◽  
Rosana Shuhama ◽  
Paulo R Menezes ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Childhood Trauma ◽  
Genomic Dna ◽  
First Episode ◽  
Childhood Trauma Questionnaire ◽  
History Of Childhood ◽  
History Of ◽  
First Episode Schizophrenia ◽  
Relationship Of ◽  
The Relationship

Aim: We investigated GRIN1, GRIN2A, GRIN2B and LINE-1 DNA methylation in first-episode schizophrenia patients, their nonaffected siblings and age- and sex-matched controls testing for associations between DNA methylation and exposition to childhood trauma. Materials & methods: The Childhood Trauma Questionnaire evaluated the history of childhood trauma. Genomic DNA was bisulfite converted and pyrosequencing was employed to quantify DNA methylation. Results: GRIN2A, GRIN2B and LINE-1 DNA methylation was not associated with childhood trauma in patients, siblings and controls. Siblings with childhood trauma had hypermethylation at CpG1 of GRIN1 compared with siblings without trauma. Conclusion: Childhood trauma may influence GRIN1 methylation in subjects with liability to psychosis, but not in frank schizophrenia or controls.

Lower LINE-1 methylation in first-episode schizophrenia patients with the history of childhood trauma

Epigenomics ◽  
2015 ◽  
Vol 7 (8) ◽  
pp. 1275-1285 ◽  
Author(s):  
Błażej Misiak ◽  
Elżbieta Szmida ◽  
Paweł Karpiński ◽  
Olga Loska ◽  
Maria M Sąsiadek ◽  
...  
Keyword(s):  
Childhood Trauma ◽  
First Episode ◽  
History Of Childhood ◽  
History Of ◽  
First Episode Schizophrenia

P.7.a.007 Is there a link between a history of childhood trauma and cognitive impairment in first-episode psychosis?

2009 ◽  
Vol 19 ◽  
pp. S682
Author(s):  
M. Aas ◽  
V. Mondelli ◽  
A. Reichenberg ◽  
M. Di Forti ◽  
B. Wiffen ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Childhood Trauma ◽  
First Episode Psychosis ◽  
First Episode ◽  
History Of Childhood ◽  
Episode Psychosis ◽  
History Of

scholarly journals Rethinking childhood adversity in chronic fatigue syndrome

2015 ◽  
Author(s):  
James E Clark ◽  
Sean Davidson ◽  
Laura Maclachlan ◽  
Megan Lynn ◽  
Julia L Newton ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Childhood Trauma ◽  
Childhood Adversity ◽  
Chronic Fatigue ◽  
Childhood Trauma Questionnaire ◽  
History Of Childhood ◽  
Fatigue Syndrome ◽  
Increased Risk ◽  
Co Morbidity ◽  
History Of

Objectives: Previous studies have consistently shown increased rates of childhood adversity in chronic fatigue syndrome (CFS). However, such aetiopathogenic studies of CFS are potentially confounded by co-morbidity and misdiagnosis particularly with depression. We used a modelling approach with existing data and data generated in our examination of the rates of childhood adversity in a sample of CFS patients who had no lifetime history of depression. Methods: The childhood trauma questionnaire (CTQ) was completed by a sample of 52 participants and 19 controls with chronic fatigue syndrome who did not meet criteria for a psychiatric disorder (confirmed using the Structured Clinical Interview for DSM-IV). Subsequently, Mediation Analysis (Baye’s Rules) was used to establish the risk childhood adversity poses for CFS with and without depression. Results: In a cohort of CFS patients with depression robustly excluded, CTQ scores were markedly lower than in all previous studies and, in contrast to these previous studies, not increased compared with healthy controls. Post-hoc analysis showed that CTQ scores correlated with the number of depressive symptoms during the lifetime worst period of low mood. The probability of developing CFS given a history of childhood trauma was shown to be 4%, a two-fold increased risk compared to the general population. However, much of this risk is mediated by the concomitant development of major depression. Discussion: The data suggests that previous studies showing a relationship between childhood adversity and CFS may be mediated by depression

scholarly journals Childhood Trauma Associated With Abnormal Resting-State Brain Network Connectivity in First-Episode Schizophrenia Patients

2020 ◽  
Author(s):  
Xiangyun Long ◽  
Jiaxin Wu ◽  
Fei Liu ◽  
Ansi Qi ◽  
Nan Huang ◽  
...  
Keyword(s):  
Childhood Trauma ◽  
Resting State ◽  
Network Connectivity ◽  
Brain Network ◽  
Traumatic Experiences ◽  
First Episode ◽  
Resting State Networks ◽  
Attention Network ◽  
Brain Network Connectivity ◽  
First Episode Schizophrenia

Abstract Childhood trauma is a central risk factor for schizophrenia. We explored the correlation between early traumatic experiences and the functional connectivity of resting-state networks. This fMRI study included 28 first-episode schizophrenia patients and 27 healthy controls. In first-episode schizophrenia patients, higher levels of childhood trauma associated with abnormal connections of resting-state networks, and these anomalies distributed among task-positive networks (i.e., ventral attention network, dorsal-ventral attention network and frontal-parietal network), and sensory networks (i.e., visual network and auditory network). These findings mentioned that childhood traumatic experiences may impact resting-state network connectivity in adulthood, mainly involving systems related to attention and execution control.

Childhood trauma and being at-risk for psychosis are associated with higher peripheral endocannabinoids

2019 ◽  
Vol 50 (11) ◽  
pp. 1862-1871 ◽  
Author(s):  
E. Appiah-Kusi ◽  
R. Wilson ◽  
M. Colizzi ◽  
E. Foglia ◽  
E. Klamerus ◽  
...  
Keyword(s):  
Risk Factors ◽  
At Risk ◽  
Childhood Trauma ◽  
Childhood Maltreatment ◽  
Peripheral Blood ◽  
Endocannabinoid System ◽  
History Of Childhood ◽  
Increased Risk ◽  
History Of

AbstractBackgroundEvidence has been accumulating regarding alterations in components of the endocannabinoid system in patients with psychosis. Of all the putative risk factors associated with psychosis, being at clinical high-risk for psychosis (CHR) has the strongest association with the onset of psychosis, and exposure to childhood trauma has been linked to an increased risk of development of psychotic disorder. We aimed to investigate whether being at-risk for psychosis and exposure to childhood trauma were associated with altered endocannabinoid levels.MethodWe compared 33 CHR participants with 58 healthy controls (HC) and collected information about previous exposure to childhood trauma as well as plasma samples to analyse endocannabinoid levels.ResultsIndividuals with both CHR and experience of childhood trauma had higher N-palmitoylethanolamine (p < 0.001) and anandamide (p < 0.001) levels in peripheral blood compared to HC and those with no childhood trauma. There was also a significant correlation between N-palmitoylethanolamine levels and symptoms as well as childhood trauma.ConclusionsOur results suggest an association between CHR and/or childhood maltreatment and elevated endocannabinoid levels in peripheral blood, with a greater alteration in those with both CHR status and history of childhood maltreatment compared to those with either of those risks alone. Furthermore, endocannabinoid levels increased linearly with the number of risk factors and elevated endocannabinoid levels correlated with the severity of CHR symptoms and extent of childhood maltreatment. Further studies in larger cohorts, employing longitudinal designs are needed to confirm these findings and delineate the precise role of endocannabinoid alterations in the pathophysiology of psychosis.

scholarly journals Suicide and history of childhood trauma among street youth

2012 ◽  
Vol 136 (3) ◽  
pp. 377-380 ◽  
Author(s):  
Scott E. Hadland ◽  
Brandon D.L. Marshall ◽  
Thomas Kerr ◽  
Jiezhi Qi ◽  
Julio S. Montaner ◽  
...  
Keyword(s):  
Childhood Trauma ◽  
Street Youth ◽  
History Of Childhood ◽  
History Of
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