Diffusion Tensor Tractography of the Motor White Matter Tracts in Man: Current Controversies and Future Directions

2005 ◽  
Vol 1064 (1) ◽  
pp. 88-97 ◽  
Author(s):  
A. I. HOLODNY
Keyword(s):  
White Matter ◽  
Diffusion Tensor ◽  
Diffusion Tensor Tractography ◽  
Future Directions ◽  
White Matter Tracts

Diffusion tensor tractography of the temporal stem on the inferior limiting sulcus

2008 ◽  
Vol 108 (4) ◽  
pp. 775-781 ◽  
Author(s):  
Feng Wang ◽  
Tao Sun ◽  
Xing-Gang Li ◽  
Na-Jia Liu
Keyword(s):  
White Matter ◽  
Diffusion Tensor ◽  
Anterior Commissure ◽  
Region Of Interest ◽  
Diffusion Tensor Tractography ◽  
Optic Radiation ◽  
Uncinate Fasciculus ◽  
White Matter Tracts ◽  
Temporal Horn ◽  
Temporal Stem

Object The aim of this study was to use diffusion tensor tractography (DTT) to define the 3D relationships of the uncinate fasciculus, anterior commissure, inferior occipitofrontal fasciculus, inferior thalamic peduncle, and optic radiation and to determine the positioning landmarks of these white matter tracts. Methods The anatomy was studied in 10 adult human brain specimens. Brain DTT was performed in 10 healthy volunteers. Diffusion tensor tractography images of the white matter tracts in the temporal stem were obtained using the simple single region of interest (ROI) and multi-ROIs based on the anatomical knowledge. Results The posteroinferior insular point is the anterior extremity of intersection of the Heschl gyrus and the inferior limiting sulcus. On the inferior limiting sulcus, this point is the posterior limit of the optic radiation, and the temporal stem begins at the limen insulae and ends at the posteroinferior insular point. The distance from the limen insulae to the tip of the temporal horn is just one third the length of the temporal stem. The uncinate fasciculus comprises the core of the anterior temporal stem, behind which the anterior commissure and the inferior thalamic peduncle are located, and they occupy the anterior third of the temporal stem. The inferior occipitofrontal fasciculus passes through the entire temporal stem. The most anterior extent of the Meyer loop is located between the anterior tip of the temporal horn and the limen insulae. Most of the optic radiation crosses the postmedian two thirds of the temporal stem. Conclusions On the inferior limiting sulcus, the posteroinferior insular point is a reliable landmark of the posterior limit of the optic radiations. The limen insulae, anterior tip of the temporal horn, and posteroinferior insular point may be used to localize the white matter fibers of the temporal stem in analyzing magnetic resonance imaging or during surgery.

Atlas-based segmentation of white matter tracts of the human brain using diffusion tensor tractography and comparison with classical dissection

NeuroImage ◽  
2008 ◽  
Vol 39 (1) ◽  
pp. 62-79 ◽  
Author(s):  
I. Nigel C. Lawes ◽  
Thomas R. Barrick ◽  
Vengadasalam Murugam ◽  
Natalia Spierings ◽  
David R. Evans ◽  
...  
Keyword(s):  
White Matter ◽  
Human Brain ◽  
Diffusion Tensor ◽  
Diffusion Tensor Tractography ◽  
White Matter Tracts

scholarly journals Assessing the effects of age on long white matter tracts using diffusion tensor tractography

NeuroImage ◽  
2009 ◽  
Vol 46 (2) ◽  
pp. 530-541 ◽  
Author(s):  
Simon W. Davis ◽  
Nancy A. Dennis ◽  
Norbou G. Buchler ◽  
Leonard E. White ◽  
David J. Madden ◽  
...  
Keyword(s):  
White Matter ◽  
Diffusion Tensor ◽  
Diffusion Tensor Tractography ◽  
White Matter Tracts

Individual differences in white and grey matter structure associated with verbal habits of thought

2019 ◽  
Author(s):  
Justin C. Hayes ◽  
Katherine L Alfred ◽  
Rachel Pizzie ◽  
Joshua S. Cetron ◽  
David J. M. Kraemer
Keyword(s):  
Individual Differences ◽  
White Matter ◽  
Cognitive Processing ◽  
Grey Matter ◽  
Structural Changes ◽  
Structural Integrity ◽  
Diffusion Tensor ◽  
Self Report ◽  
White Matter Tracts

Modality specific encoding habits account for a significant portion of individual differences reflected in functional activation during cognitive processing. Yet, little is known about how these habits of thought influence long-term structural changes in the brain. Traditionally, habits of thought have been assessed using self-report questionnaires such as the visualizer-verbalizer questionnaire. Here, rather than relying on subjective reports, we measured habits of thought using a novel behavioral task assessing attentional biases toward picture and word stimuli. Hypothesizing that verbal habits of thought are reflected in the structural integrity of white matter tracts and cortical regions of interest, we used diffusion tensor imaging and volumetric analyses to assess this prediction. Using a whole-brain approach, we show that word bias is associated with increased volume in several bilateral language regions, in both white and grey matter parcels. Additionally, connectivity within white matter tracts within an a priori speech production network increased as a function of word bias. These results demonstrate long-term structural and morphological differences associated with verbal habits of thought.

scholarly journals White matter in prolonged glucocorticoid response to psychological stress in schizophrenia

2021 ◽  
Author(s):  
Eric L. Goldwaser ◽  
Joshua Chiappelli ◽  
Mark D. Kvarta ◽  
Xiaoming Du ◽  
Zachary B. Millman ◽  
...  
Keyword(s):  
White Matter ◽  
Psychological Stress ◽  
Stress Responses ◽  
Diffusion Tensor ◽  
Brain Network ◽  
White Matter Tracts ◽  
Cortisol Reactivity ◽  
Cortisol Responses ◽  
Psychological Stressor ◽  
Post Stress

AbstractStress is implicated in psychosis etiology and exacerbation, but pathogenesis toward brain network alterations in schizophrenia remain unclear. White matter connects limbic and prefrontal regions responsible for stress response regulation, and white matter tissues are also vulnerable to glucocorticoid aberrancies. Using a novel psychological stressor task, we studied cortisol stress responses over time and white matter microstructural deficits in schizophrenia spectrum disorder (SSD). Cortisol was measured at baseline, 0-, 20-, and 40-min after distress induction by a psychological stressor task in 121 SSD patients and 117 healthy controls (HC). White matter microstructural integrity was measured by 64-direction diffusion tensor imaging. Fractional anisotropy (FA) in white matter tracts were related to cortisol responses and then compared to general patterns of white matter tract deficits in SSD identified by mega-analysis. Differences between 40-min post-stress and baseline, but not acute reactivity post-stress, was significantly elevated in SSD vs HC, time × diagnosis interaction F2.3,499.9 = 4.1, p = 0.013. All SSD white matter tracts were negatively associated with prolonged cortisol reactivity but all tracts were positively associated with prolonged cortisol reactivity in HC. Individual tracts most strongly associated with prolonged cortisol reactivity were also most impacted in schizophrenia in general as established by the largest schizophrenia white matter study (r = −0.56, p = 0.006). Challenged with psychological stress, SSD and HC mount similar cortisol responses, and impairments arise in the resolution timeframe. Prolonged cortisol elevations are associated with the white matter deficits in SSD, in a pattern previously associated with schizophrenia in general.

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